| Sana-Rae Limited | Administrative & support | 2019 |
| Sanaki Limited | Health & social care | 2021 |
| Sand Lane Solar Farm Limited | Construction | 2025 |
| Sandeman Events Limited | Arts & recreation | 2016 |
| Sanders Consulting Associates Limited | Professional & scientific | 2006 |
| Sanders HR Solutions Ltd | Professional & scientific | 2023 |
| Sandhu Newsagent Ltd | Wholesale & retail | 2020 |
| Sandmartin Properties Limited | Real estate | 2021 |
| Sandra DB Ltd | Health & social care | 2018 |
| Sandra Tomes Limited | Financial services | 2011 |
| Sandrus Properties Limited | Real estate | 2013 |
| Sandstorm Studios Inc Limited | Information & communication | 2020 |
| Sandy Consultancy Private Limited | Information & communication | 2023 |
| Sandy's Plumbing Limited | Construction | 2003 |
| Sangana Homes Limited | Real estate | 2018 |
| Sanidine Tech Ltd | Information & communication | 2022 |
| Sankan Systems Ltd | Information & communication | 2025 |
| Sanmak Ltd | Information & communication | 2014 |
| Santa's Flying Sleigh C.I.C. | Arts & recreation | 2024 |
| SAP Pizza Ltd | Hospitality | 2024 |
| Sapientum Limited | Professional & scientific | 2007 |
| Sapta Tech Ltd | Information & communication | 2026 |
| Saracen Ventures UK Limited | Construction | 2011 |
| Sarah Howard Design Studio Ltd | Professional & scientific | 2020 |
| Saray Investments Ltd | Real estate | 2024 |
| Sarigu Ltd | Health & social care | 2021 |
| Sarl Danielson France | | 1998 |
| Sarmin Consulting Limited | Mining & quarrying | 2006 |
| SAS Calibrations Ltd | Professional & scientific | 2018 |
| Satb Limited | Wholesale & retail | 2009 |
| Satellite Terrain Engineering Ltd | Professional & scientific | 2016 |
| Satellite, Aerial & Lightning Services Ltd | Construction | 2007 |
| Sathshiv Technologies Limited | Information & communication | 2020 |
| Satkar Services Ltd | Hospitality | 2024 |
| Saturn Imaging Limited | Professional & scientific | 2004 |
| Save 4 Life Ltd | Administrative & support | 2020 |
| Save Hand Cabs & Recovery Limited | Transport & logistics | 2025 |
| Save OUR Planet Energy Limited | Construction | 2022 |
| Savetime Haulage Ltd | Transport & logistics | 2015 |
| Savi Energy Ltd | Professional & scientific | 2019 |
| Savidant Limited | Information & communication | 2013 |
| Savvy Drinks Group Ltd | Manufacturing | 2022 |
| SAW Mill Media Ltd | Information & communication | 2013 |
| Sawabin Limited | Extraterritorial | 2012 |
| Sawie Ltd | Information & communication | 2021 |
| SB Construction & Consulting Limited | Construction | 2019 |
| SB Courier Services Limited | Transport & logistics | 2025 |
| SB Decor Ltd | Construction | 2023 |
| SB Survey and Compliance Limited | Professional & scientific | 2025 |
| SBL Enterprises Limited | Real estate | 2014 |
| Sbmc Limited | Professional & scientific | 2021 |
| Sbss Couriers Ltd | Transport & logistics | 2025 |
| Scalent Associates Limited | Information & communication | 2025 |
| Scaleright AI Ltd | Information & communication | 2025 |
| Scanland Surveys Ltd | Professional & scientific | 2024 |
| SCC Property Ltd | Transport & logistics | 2015 |
| Scene Lighting Solutions Limited | Other services | 2012 |
| Sceptre Building Limited | Construction | 2018 |
| Schoenhut Ltd | Wholesale & retail | 2025 |
| School Adventures Limited | Arts & recreation | 2026 |
| School Fundraising Limited | Wholesale & retail | 2008 |
| School Gate Coffee Ltd | Hospitality | 2021 |
| School of Outdoors Limited | Education | 2019 |
| Schreibs & Partners Limited | Real estate | 2021 |
| Schurter Electronics Limited | Wholesale & retail | 2003 |
| Schurter Limited | Professional & scientific | 1947 |
| Scilly Adventures Ltd | Information & communication | 2026 |
| SCM Building Ltd | Construction | 2025 |
| Scope Care Finances Ltd | Administrative & support | 2026 |
| Scope Care Services Ltd | Health & social care | 2021 |
| Scopeit Solutions Ltd | Professional & scientific | 2013 |
| Scrapco Ltd | Wholesale & retail | 2025 |
| Screedmeister Ltd | Construction | 2020 |
| Script Mementos Ltd | Manufacturing | 2025 |
| Scriptpad Limited | Information & communication | 2023 |
| Scrumptious Food Festivals Limited | Arts & recreation | 2018 |
| Scruples of Wendover Limited | Other services | 2015 |
| Sculpt by Maia Limited | Arts & recreation | 2026 |
| SD Dynamics Consultancy Limited | Information & communication | 2022 |
| SD Property Investment Holdings Limited | Real estate | 2022 |
| SD Psychology Ltd | Health & social care | 2025 |
| SDB Consulting & Resourcing Ltd | Information & communication | 2012 |
| SDT Housing Corporation Ltd | Real estate | 2024 |
| SDT Info Services Ltd | Information & communication | 2018 |
| Seafield Holiday Lettings Ltd | Real estate | 2016 |
| Seal Seam Limited | Manufacturing | 1963 |
| Seamless Fabrications Limited | Manufacturing | 2019 |
| Seasonal Trading Limited | Wholesale & retail | 2004 |
| Seasons Europe Ltd | Financial services | 2020 |
| Seasons Global Suppliers Limited | Wholesale & retail | 2024 |
| Seaton Investment Properties Ltd | Real estate | 2022 |
| SEB Carpentry Limited | Construction | 2010 |
| Seb-Seb Limited | Wholesale & retail | 2024 |
| Secplus Ltd | Information & communication | 2024 |
| Secteleport Ltd | Transport & logistics | 2021 |
| Secure Teleport Ltd | Transport & logistics | 2026 |
| Securedesk Limited | Professional & scientific | 2003 |
| Secureflex UK Ltd | Construction | 2023 |
| Sedgas Ltd | Construction | 2024 |
| Sedrup Holdings Limited | Professional & scientific | 1977 |