| Ryka UK Ltd | Construction | 2014 |
| Rytikal Ltd | Extraterritorial | 2025 |
| S & T Ambro Limited | Administrative & support | 2026 |
| S a Mullett Limited | Construction | 2011 |
| S C ASH Consultants Ltd | Professional & scientific | 2013 |
| S D L Consultants Limited | Professional & scientific | 2008 |
| S HAY Fire Safety Limited | Public administration | 2024 |
| S J Kitchen Electrical Ltd | Construction | 2010 |
| S King Heating & Plumbing Ltd | Construction | 2010 |
| S P Valentine & Co Ltd | Construction | 2017 |
| S V Pharmacies Limited | Wholesale & retail | 1999 |
| S&A Builders and Decorators Limited | Construction | 2016 |
| S&A Investment Property Ltd | Real estate | 2019 |
| S&A Roofing Services Ltd | Construction | 2025 |
| S&D Facilities Ltd | Administrative & support | 2018 |
| S&D Holdings (Group) Ltd | Financial services | 2023 |
| S&D Maintenance Ltd | Administrative & support | 2018 |
| S&E Ventures Ltd | Wholesale & retail | 2016 |
| S&G Property Holdings Ltd | Construction | 2020 |
| S&I Motors Ltd | Wholesale & retail | 2022 |
| S&J Accommodations Ltd | Real estate | 2022 |
| S&P Care Services Ltd | Health & social care | 2020 |
| S&S Brothers Group Ltd | Professional & scientific | 2025 |
| S&S Couriers (Bucks) Ltd | Transport & logistics | 2022 |
| S&S Curry Ltd | Hospitality | 2021 |
| S&S Kitchen (Bucks) Ltd | Hospitality | 2023 |
| S&S Kitchen Catering Limited | Hospitality | 2026 |
| S&S Project Advisory Limited | Professional & scientific | 2025 |
| S.C. (Chiltern) Ltd | Hospitality | 2013 |
| S.D.S Garden Services Ltd | Administrative & support | 2021 |
| S.L.P. (UK) Limited | Manufacturing | 1993 |
| S.M.Fowler Design Ltd | Information & communication | 2016 |
| S.S Settlement Ltd | Real estate | 2022 |
| S.Seshan Ltd | Transport & logistics | 2015 |
| S.Turner Construction Ltd | Construction | 2022 |
| Saaradhi Technologies Ltd | Information & communication | 2019 |
| SAB Builders & Landscaping Ltd | Construction | 2019 |
| SAB1R Properties Ltd | Real estate | 2025 |
| Saber Properties Ltd | Real estate | 2016 |
| Sabrikas Ltd | Wholesale & retail | 2015 |
| Saco Healthcare Limited | Health & social care | 2020 |
| Sactrette Limited | Wholesale & retail | 2024 |
| SAD Group Holdings Ltd | Financial services | 2022 |
| Saddleback Builders Ltd | Construction | 2021 |
| Sadie Street Properties Ltd | Real estate | 2024 |
| Sadies Beauty & Cosmetic Studio Ltd | Other services | 2025 |
| Sadlowski Ltd | Transport & logistics | 2016 |
| Safari Cafe Ltd | Hospitality | 2018 |
| Safari Partners Ltd | Professional & scientific | 2021 |
| Safe Electronics Ltd | Construction | 2025 |
| Safe Testers Ltd | Professional & scientific | 2023 |
| Safeguard Glass & Glazing Ltd | Construction | 2025 |
| Safeguard Glass Co. Ltd | Construction | 2025 |
| Safemark Global Resources Limited | Professional & scientific | 2014 |
| Safepaws Transport Ltd | Transport & logistics | 2025 |
| Safer Care Pathways Ltd | Health & social care | 2025 |
| Safety, Fire & Environment (SFE) Ltd. | Administrative & support | 2007 |
| SAFEWAYS1 UK Ltd | Professional & scientific | 2019 |
| Saffron Business Analysis Ltd | Information & communication | 2020 |
| Saffron Hairdressing Limited | Other services | 2016 |
| Safir Transport Limited | Transport & logistics | 2024 |
| Sagar 786 Limited | Real estate | 2025 |
| Sagesupportedliving Limited | Health & social care | 2025 |
| Sagewood Care Limited | Health & social care | 2018 |
| Sahidhruv Ltd | Real estate | 2025 |
| SAI Business Services Limited | Other services | 2013 |
| SAI Dyuthi Consulting Limited | Information & communication | 2013 |
| SAI Links Ltd | Transport & logistics | 2025 |
| SAI RAM Healthcare Ltd | Health & social care | 2015 |
| Saimadu Civil Engineering Limited | Construction | 2022 |
| Sair Technologies Limited | Wholesale & retail | 2023 |
| Saju Services Ltd | Health & social care | 2020 |
| Saketh Limited | Administrative & support | 2019 |
| Sako Technologies Limited | Information & communication | 2011 |
| Salama Limited | Professional & scientific | 2008 |
| Saldere Limited | Households | 1986 |
| Salesmade Coatings Limited | Manufacturing | 1986 |
| Salesmade Fabrications Limited | Manufacturing | 2018 |
| Salesmade Holdings Limited | Professional & scientific | 2017 |
| Salesmade Limited | Manufacturing | 1980 |
| Salesmade Products Limited | Manufacturing | 2000 |
| Salisbury Court Property Management Ltd | Households | 2013 |
| Sally Philp Consulting Limited | Arts & recreation | 2013 |
| Salmiya Ltd | Information & communication | 2018 |
| Salome James Limited | Professional & scientific | 2026 |
| Salt & Spices Superstore Ltd | Wholesale & retail | 2024 |
| Salty Fingers Ltd | Manufacturing | 2025 |
| Salty Shed Ltd | Hospitality | 2022 |
| Salutem Structures Limited | Professional & scientific | 2018 |
| Salzer U.K. Limited | Manufacturing | 1992 |
| SAM D Limited | Administrative & support | 2015 |
| SAM Jackson Designs Ltd | Professional & scientific | 2024 |
| Samantha's Hair Lounge Ltd | Other services | 2026 |
| Samanvi Limited | Professional & scientific | 2022 |
| Samar Consultancy Services Ltd | Information & communication | 2022 |
| Samelle Limited | Professional & scientific | 2021 |
| Sampson LOW Limited | Extraterritorial | 1997 |
| Samron Ventures Limited | Wholesale & retail | 2025 |
| Sams Takeaway Aylesbury Ltd | Hospitality | 2018 |
| Samson Windows Limited | Extraterritorial | 2009 |