| Envy Car Hire Ltd | Administrative & support | 2019 |
| Epco Utilities Group Ltd | Extraterritorial | 2017 |
| Epco.Uk Limited | Construction | 2005 |
| EPH South Ltd | Transport & logistics | 2020 |
| Ephratah Health Limited | Administrative & support | 2020 |
| Epic Relics Limited | Wholesale & retail | 2024 |
| Epicure Business Consultants UK Ltd | Professional & scientific | 2021 |
| Episode Management Limited | Professional & scientific | 2026 |
| Epsilon Informatics Limited | Information & communication | 2021 |
| Equate Group Limited | Information & communication | 2006 |
| Equilibrium Products Limited | Manufacturing | 1999 |
| Equitable Life Assurance Society,(The) | Financial services | 1892 |
| EQUO3 Limited | Arts & recreation | 2015 |
| Equus Consulting Ltd | Information & communication | 2022 |
| Erebus (Developments) Ltd | Extraterritorial | 2015 |
| Erin K Donaldson Ltd | Information & communication | 2018 |
| Erinmore Homes Limited | Construction | 2025 |
| Erinyes International Ltd | Administrative & support | 1999 |
| Erma Trading Ltd | Hospitality | 2024 |
| Eroya Ltd | Professional & scientific | 2026 |
| ERP Testing Solutions Ltd | Information & communication | 2025 |
| ES Plumbing and Heating Limited | Extraterritorial | 2023 |
| Esby Digital Ltd | Information & communication | 2025 |
| Escape Currency Ltd | Professional & scientific | 2025 |
| Escape Wellbeing Therapies Limited | Other services | 2019 |
| ESE Management Limited | Professional & scientific | 2011 |
| Esquires Coffee Shepherd's Bush Limited | Hospitality | 2021 |
| Esri (UK) Cambridge Limited | Extraterritorial | 1979 |
| Esri (UK) Limited | Information & communication | 1976 |
| Esri (UK) Property Limited | Real estate | 2005 |
| Esri (UK) Services Limited | Extraterritorial | 2000 |
| Esri Holdings Limited | Administrative & support | 1991 |
| Esri Investments Limited | Administrative & support | 2000 |
| Essential Design & Build Limited | Construction | 2014 |
| Essentially Financial Ltd | Financial services | 2010 |
| Est.Brothers Ltd | Wholesale & retail | 2025 |
| Estic Associates Ltd | Information & communication | 2019 |
| Estovika Limited | Real estate | 2025 |
| Ether Online Ltd | Wholesale & retail | 2021 |
| Ether Solutions Ltd | Information & communication | 1999 |
| Etherconsult (UK) Limited | Professional & scientific | 2018 |
| Etherington Associates Limited | Professional & scientific | 2001 |
| Ethical Bear Limited | Extraterritorial | 2020 |
| Ethos Farm Holdings Limited | Financial services | 2021 |
| Ethos Farm Limited | Administrative & support | 2016 |
| Etive Holidays Limited | Hospitality | 2021 |
| Ettaholdings Ltd | Extraterritorial | 2023 |
| ETX Aylesbury Limited | Wholesale & retail | 2023 |
| EU Auto Parts Ltd | Wholesale & retail | 2019 |
| EU Auto Repair Ltd | Wholesale & retail | 2024 |
| EU Property Holdings Ltd | Real estate | 2026 |
| Euphoria Realty Ltd | Real estate | 2025 |
| Eurasia Accounting & Investment Limited | Professional & scientific | 2024 |
| Eurojack Limited | Information & communication | 2016 |
| European Astrotech Limited | Professional & scientific | 2007 |
| EV Energy Point Ltd | Manufacturing | 2024 |
| Evanet Services Limited | Professional & scientific | 2008 |
| Evans Medical Limited | Health & social care | 2022 |
| Evantime Limited | Information & communication | 2017 |
| Evavas Medical Cosmetics Ltd | Other services | 2023 |
| Even Better Teaching Ltd | Other services | 2019 |
| Event Matters Ltd | Extraterritorial | 2013 |
| Evente Limited | Information & communication | 2022 |
| Ever Brite Cleaning Services Limited | Administrative & support | 1977 |
| Ever Brite Maintenance Limited | Construction | 2026 |
| Ever Brite Pest Control Limited | Administrative & support | 2025 |
| Ever Mart Ltd | Wholesale & retail | 2025 |
| Evergreen Supported Living Ltd | Health & social care | 2025 |
| Everwood Properties Ltd | Real estate | 2025 |
| Every Life International | Other services | 2010 |
| Every US Ltd | Professional & scientific | 2025 |
| Everything Figures Ltd | Professional & scientific | 2018 |
| Everytrade UK Ltd | Construction | 2023 |
| Evisa Limited | Administrative & support | 2008 |
| Evolution Accountancy Limited | Professional & scientific | 2014 |
| Evolution DM Ltd | Construction | 2020 |
| Evolve Childrens Services Ltd | Health & social care | 2025 |
| Evolve Electrical Solutions (London) Ltd | Construction | 2020 |
| Evolve Xxii Ltd | Information & communication | 2026 |
| Evon Media Limited | Information & communication | 2014 |
| Ew-Aerotechsystems Limited | Other services | 2017 |
| Ewan Motors Limited | Wholesale & retail | 2023 |
| Ewan Properties Limited | Real estate | 2024 |
| EWH Properties Ltd | Real estate | 2025 |
| Ewing Technologies Ltd | Information & communication | 2015 |
| Exaim Limited | Information & communication | 2018 |
| Exalt Strength Ltd | Education | 2020 |
| Excel Auto Enhancement Limited | Extraterritorial | 2016 |
| Excel-Dents (Oxford) Limited | Wholesale & retail | 2006 |
| Excel-Dents Limited | Wholesale & retail | 2003 |
| Excellence Training Limited | Information & communication | 2011 |
| Excellone Technologies Limited | Information & communication | 2007 |
| Excelsior Regulatory Consulting Limited | Professional & scientific | 2020 |
| Exchange Cleaning Ltd | Administrative & support | 2023 |
| Exclusive Oriental Classics (UK) Limited | Wholesale & retail | 1987 |
| Exclusive Promo Ltd | Arts & recreation | 2009 |
| Excsuite Limited | Financial services | 2017 |
| Executive Coaching Tools Limited | Administrative & support | 2007 |
| Executive Elevation Services Ltd | Professional & scientific | 2024 |
| Executive Private Hire (EPH) Limited | Transport & logistics | 2010 |