| Driving Force One Limited | Transport & logistics | 2002 |
| Drop Highlight Limited | Information & communication | 2025 |
| Drop Shot Cars Ltd | Wholesale & retail | 2019 |
| Drover Developments Ltd | Construction | 2020 |
| Droxford Leisure Group Limited | Professional & scientific | 2023 |
| DRS Kumar Ltd | Information & communication | 2018 |
| Drsalvador Consultancy Ltd | Education | 2020 |
| Druids Close Management Ltd | Real estate | 2020 |
| Drumup Limited | Other services | 2014 |
| DRW Advisory Limited | Professional & scientific | 2018 |
| DS Decorating Ltd | Construction | 2026 |
| DS Landscape Services Ltd | Administrative & support | 2026 |
| DS Motor-Inn Ltd | Wholesale & retail | 2024 |
| DS Refurbishment Services Ltd | Manufacturing | 2025 |
| DS Speed Transport Limited | Transport & logistics | 2016 |
| DSB Ventures Ltd | Professional & scientific | 2007 |
| DSL Kitchens Ltd | Wholesale & retail | 2022 |
| Dsolution.Es Limited | Administrative & support | 2022 |
| DSP Homes Limited | Real estate | 2021 |
| DSP Testing Solutions Limited | Information & communication | 2018 |
| DSS Global Services Ltd | Administrative & support | 2016 |
| Dstell Services Ltd | Construction | 2026 |
| Dsys Plus Limited | Information & communication | 1989 |
| Dtasip Ltd | Information & communication | 2026 |
| DTB Consultants Limited | Construction | 2007 |
| DTB Procurement Limited | Professional & scientific | 2014 |
| DTD Vendors Ltd | Information & communication | 2026 |
| DTM Academy Ltd | Health & social care | 2026 |
| DTM Property Ltd | Real estate | 2019 |
| DTW Associates Limited | Wholesale & retail | 2004 |
| Dudswell PT Limited | Administrative & support | 2026 |
| Duff's Stuff Limited | Construction | 2013 |
| Duffle BAG Consulting Ltd | Information & communication | 2019 |
| Duglee Property Ltd | Real estate | 2023 |
| Dukes Dwellings Ltd | Other services | 2023 |
| Dulce Grace Ltd | Extraterritorial | 2023 |
| DUN Homes Ltd | Real estate | 2021 |
| Dunbar Financial Services Ltd | Professional & scientific | 2014 |
| Dune Lighting Solutions Ltd | Information & communication | 2024 |
| Dunnes Management & Consultants Ltd | Construction | 2025 |
| Dunscribe Limited | Real estate | 1979 |
| Dunstable Consultants Limited | Health & social care | 2023 |
| Dunvegan Lodge Freehold Limited | Households | 2021 |
| Duorend Limited | Construction | 2014 |
| Dura Construction Support Ltd | Professional & scientific | 2019 |
| Durans Hair Studio Limited | Other services | 2017 |
| Dustbunnies Cleaning Ltd | Administrative & support | 2024 |
| Dusty Old Books Limited | Wholesale & retail | 2000 |
| DUX (Company Secretary) Limited | Professional & scientific | 2004 |
| DUX (Holdings) Limited | Financial services | 2016 |
| DUX Advisory Limited | Professional & scientific | 2014 |
| DUX Audit LLP | | 2023 |
| DUX Aylesbury Limited | Professional & scientific | 2003 |
| Duxanaesthesia Limited | Health & social care | 2024 |
| DV8 Agency Ltd. | Wholesale & retail | 2017 |
| DV8, Light Commercials, Service, Repair & Sales Limited | Wholesale & retail | 2022 |
| DVN Brickwork Ltd | Construction | 2024 |
| DW Strategy Ltd | Professional & scientific | 2024 |
| Dwsparktech Limited | Construction | 2014 |
| Dwyer's Professional House Painting Ltd | Construction | 2014 |
| DX Hosting Ltd | Information & communication | 2008 |
| DX Networks Ltd | Information & communication | 2005 |
| DXN Real Estate Limited | Real estate | 2025 |
| Dxsurgery Limited | Information & communication | 2020 |
| Dy-Rect Services Limited | Construction | 1995 |
| Dyconsulting Ltd | Information & communication | 2024 |
| Dygas Detailing Limited | Wholesale & retail | 2021 |
| Dynamic Digital Marketing Solutions Ltd | Information & communication | 2025 |
| Dynamic Financial Planning Ltd | Financial services | 2023 |
| Dynamos Burgers Ltd | Hospitality | 2025 |
| Dzimba Developers Limited | Administrative & support | 2012 |
| D’Oyleys Farm Ludgershall Limited | Agriculture & fishing | 2025 |
| E & V Flahavan Ltd | Wholesale & retail | 2026 |
| E BEE Media Limited | Administrative & support | 2017 |
| E C S (London) Ltd | Real estate | 1993 |
| E E & Brian Smith (1928) Limited | Wholesale & retail | 1971 |
| E Hayes (Supplies) Ltd | Construction | 2010 |
| E P Building Contractors Ltd | Construction | 2013 |
| E&A Property Services Limited | Construction | 2019 |
| E&F Glazing & Property Maintenance Ltd | Construction | 2025 |
| E-Pickpack Ltd | Wholesale & retail | 2007 |
| E. Sharp (Electrical) Limited | Construction | 1975 |
| E.D.L Constructions Ltd | Construction | 2024 |
| E.G. Enterprises Limited | Information & communication | 1981 |
| E.H.Oakley and Company Limited | Manufacturing | 1958 |
| E.Prime Carpentry Ltd | Construction | 2026 |
| E21 Accounting Limited | Professional & scientific | 2024 |
| E24 Plumbing and Heating Ltd | Construction | 2023 |
| Eagle Construction VS Ltd | Construction | 2023 |
| Eagle Pizza House Ltd | Hospitality | 2018 |
| Eaglepark Limited | Financial services | 2000 |
| Eamont Holdings Limited | Professional & scientific | 1995 |
| Earlesford Ltd | Manufacturing | 2020 |
| Early Bird Associates Limited | Administrative & support | 2001 |
| Easi Cabs Limited | Transport & logistics | 2022 |
| East Midland Agricultural Services Limited | Professional & scientific | 1961 |
| Eastwood Installations Limited | Construction | 2022 |
| Easy Cloud Solutions Ltd | Information & communication | 2023 |
| Easy Digital Solutions Ltd | Information & communication | 2015 |
| Easy Go Taxis Ltd | Transport & logistics | 2025 |