| Discovery Property Holdings UK Ltd | Real estate | 2025 |
| Dispense Control Systems Limited | Administrative & support | 2015 |
| Disrupt Care Ltd | Professional & scientific | 2015 |
| Disrupt the Market Ltd | Professional & scientific | 2016 |
| Diversa Metals Limited | Administrative & support | 2017 |
| Divide and Conker Limited | Administrative & support | 2021 |
| Divya Ltd | Wholesale & retail | 2022 |
| Diyar AL Harmain Travel & Tours Ltd | Administrative & support | 2025 |
| DJC Electrical Contractors Ltd | Construction | 2010 |
| DJE Consultancy Ltd | Professional & scientific | 2012 |
| DJE Property Management Ltd | Real estate | 2025 |
| DJR Enterprises Ltd | Real estate | 2023 |
| DJS Cleaning Solutions Ltd | Administrative & support | 2025 |
| DK Development Services Ltd | Administrative & support | 2017 |
| DK Electrical & Auto Services Ltd | Wholesale & retail | 2019 |
| Dlsa Consulting Limited | Professional & scientific | 2019 |
| Dltjs Limited | Arts & recreation | 2017 |
| DM Brickwork & Construction Ltd | Construction | 2022 |
| DM Partners Recruitment Ltd | Information & communication | 2019 |
| DMA Choi Limited | Health & social care | 2019 |
| Dmatteo Ltd | Construction | 2018 |
| DMH Thermal Ltd | Construction | 2014 |
| Dmoc Consulting Limited | Professional & scientific | 2025 |
| DMS Computing Limited | Information & communication | 1997 |
| Dndestates Limited | Real estate | 2025 |
| DNH Estates Ltd | Real estate | 2026 |
| DO More Services Limited | Administrative & support | 2017 |
| Dobbs Construction Ltd | Construction | 2018 |
| Doggyjumps Agility Hire Services Limited | Administrative & support | 2013 |
| Doherty Partners Limited | Professional & scientific | 2018 |
| Doka Rally Ltd | Transport & logistics | 2019 |
| Dolce Refreshments Limited | Hospitality | 2021 |
| DOM Management Limited | Real estate | 2015 |
| Domestic Energy Services Limited | Professional & scientific | 2015 |
| Domisal Ltd | Health & social care | 2019 |
| Dommy Daycare Limited | Health & social care | 2024 |
| Domy Construction Ltd | Construction | 2024 |
| Donadytrans Ltd | Transport & logistics | 2018 |
| Doncbach Limited | Administrative & support | 2021 |
| Doner 65 Ltd | Hospitality | 2025 |
| Donna B FBA Ltd | Wholesale & retail | 2026 |
| Doradaisy Consultancy Ltd | Health & social care | 2026 |
| Dormer Close RTM Company Limited | Households | 2005 |
| Dormouse Properties Limited | Real estate | 2022 |
| Dorney Wood Limited | Professional & scientific | 2006 |
| Dornoch Court Ltd | Construction | 2020 |
| Dorsett Property Partners Ltd | Real estate | 2025 |
| Doski Barbers Limited | Other services | 2026 |
| DOT DOT Media Ltd | Professional & scientific | 2025 |
| DOT Eight Ltd | Information & communication | 2025 |
| Double Eight Tasty Limited | Hospitality | 2024 |
| Double Entry Bookkeeping Limited | Professional & scientific | 2023 |
| Double Glazing Direct Ltd | Construction | 2011 |
| Double Helix Pharma UK Ltd | Wholesale & retail | 2022 |
| Double O Media Ltd | Professional & scientific | 2025 |
| Dough and Beats Limited | Hospitality | 2025 |
| Doughnut TV Ltd | Information & communication | 2016 |
| Douglass Anaesthetic Services Ltd | Health & social care | 2025 |
| Dove Networks Limited | Information & communication | 1987 |
| Dove Place Residents Limited | Households | 1990 |
| Dovetail Carpenters Limited | Construction | 2006 |
| Down at the Farm Ltd | Other services | 2021 |
| Down South Ltd | Wholesale & retail | 2016 |
| Downforce Real Estate Ltd | Real estate | 2024 |
| Downton Security Services Limited | Administrative & support | 2023 |
| DP Cairnie Plumbing and Heating (Aylesbury) Ltd | Construction | 2024 |
| DP Security Services Limited | Administrative & support | 2010 |
| DP Voice Solutions Limited | Information & communication | 2016 |
| Dp&B Ltd | Information & communication | 2015 |
| Dpav Properties Ltd | Real estate | 2018 |
| DPG Plumbing and Heating Ltd | Construction | 2019 |
| DPH Services Ltd | Construction | 2024 |
| DPI Advisory Limited | Professional & scientific | 2021 |
| DR a. Zaman Private GP Limited | Real estate | 2023 |
| DR Albert Zandvoort Limited | Health & social care | 2016 |
| DR Barati Medical Services Ltd | Health & social care | 2025 |
| DR H Mallya Ltd | Health & social care | 2018 |
| DR Luck Consulting Limited | Health & social care | 2019 |
| DR Sylvia Ltd | Administrative & support | 2003 |
| Dr.Gloves Ltd | Wholesale & retail | 2026 |
| Dragon Eats Limited | Hospitality | 2021 |
| Dragon Fire UND Ice Wall Security Limited | Administrative & support | 2024 |
| Dragtek Autos Ltd | Extraterritorial | 2022 |
| Dragtek Customs Ltd | Extraterritorial | 2018 |
| Drake Digital Ltd | Information & communication | 2026 |
| Dram-A Whisky Odyssey Ltd | Wholesale & retail | 2021 |
| Dravens HC Franchise Ltd | Other services | 2019 |
| Dravens HC Limited | Health & social care | 2024 |
| DRD Roofing Limited | Construction | 2000 |
| Dream & Believe Events Ltd | Wholesale & retail | 2021 |
| Dream & Care Limited | Public administration | 2025 |
| Dream Stage Media Limited | Information & communication | 2011 |
| Dreamwood Homes Ltd | Other services | 2025 |
| Dreamz Desserts (AYL) Limited | Hospitality | 2022 |
| Drgngp Ltd | Health & social care | 2023 |
| Drift Management Limited | Professional & scientific | 1993 |
| Drip and Drive Limited | Hospitality | 2023 |
| Drishti Collective Ltd | Other services | 2025 |
| Drive Cover Ltd | Wholesale & retail | 2022 |
| Driving Duties Limited | Transport & logistics | 2019 |