| D'Or Nail & Spa Ltd | Other services | 2025 |
| D.F. Baxter (Engineering) Limited | Real estate | 1977 |
| Dabello Ltd | Transport & logistics | 2021 |
| Dairy GEN Limited | Hospitality | 1993 |
| Dairy R US Ltd | Wholesale & retail | 2024 |
| Dalbury Hill Holdings Ltd | Wholesale & retail | 2026 |
| Danage Engineering Ltd | Manufacturing | 2024 |
| Daniel Salt Ltd | Manufacturing | 2019 |
| Daniel Wright Architectural Design Ltd | Professional & scientific | 2024 |
| Dans Tyre Services Ltd | Wholesale & retail | 2021 |
| Dare Consultancy Limited | Information & communication | 2019 |
| Darfish Limited | Construction | 1980 |
| Darley Moor Motor Cycle Road Racing Club Limited | Arts & recreation | 1980 |
| Darrell Smith Technology Services Limited | Information & communication | 2018 |
| David C Robinson Limited | Information & communication | 2005 |
| David Calladine Builders Limited | Construction | 2003 |
| David Clarke Electrical Limited | Construction | 2013 |
| DCC Africa Ltd | Other services | 2025 |
| DCC Europe Limited | Financial services | 2024 |
| DCM Science Ltd | Information & communication | 2023 |
| DCS Spencer (1) Ltd | Real estate | 2013 |
| DE Carnys Capital Limited | Professional & scientific | 2019 |
| Debson Healthcare Ltd | Health & social care | 2025 |
| Debus Designs Ltd | Wholesale & retail | 2017 |
| Dekho Design Limited | Professional & scientific | 2004 |
| Dekoda Limited | Extraterritorial | 2007 |
| Deli NO 7 Ltd | Wholesale & retail | 2025 |
| Delivery & Change Ltd | Professional & scientific | 2016 |
| Deltav Investments | Professional & scientific | 2019 |
| Deniz and Kivanc Limited | Hospitality | 2021 |
| Derby County (the Rams) Holdings Limited | Financial services | 2025 |
| Derby County (the Rams) Limited | Arts & recreation | 2022 |
| Derby County (the Rams) Stadium Limited | Real estate | 2018 |
| Derby Driveways and Construction Limited | Construction | 2018 |
| Derby Road Developments LLP | | 2008 |
| Derbyshire Autogas Systems Limited | Wholesale & retail | 2014 |
| Derbyshire Dales Design and Print Limited | Administrative & support | 1991 |
| Derbyshire Diggers Plant Hire Limited | Construction | 2009 |
| Derbyshire Green Heating Company Limited | Construction | 2014 |
| Derbyshire Quads Ltd | Wholesale & retail | 2005 |
| Derbyshire Salons Limited | Extraterritorial | 2009 |
| Derbyshire Self Storage Limited | Other services | 2000 |
| Derbyshire Welding & Fabrication Ltd | Manufacturing | 2020 |
| Derwent Interim Supply Chain Ltd | Extraterritorial | 2017 |
| Derwent Valley Joinery Ltd | Construction | 2020 |
| Detailed Renovations & Building Ltd | Construction | 2026 |
| Devall Ltd | Construction | 2016 |
| Deville and Lear Holdings Limited | Financial services | 2024 |
| Deville and Lear Limited | Construction | 1988 |
| Dezza Arslan Mobile Barber Services Ltd | Other services | 2020 |
| Dgmh Properties Ltd | Real estate | 2021 |
| Digital Online Services Limited | Information & communication | 2023 |
| Dingle Consulting Ltd | Professional & scientific | 2020 |
| Discount Living Aids Limited | Wholesale & retail | 2012 |
| Discover Ashbourne CIC | Other services | 2024 |
| Distefano Property Law Limited | Professional & scientific | 2025 |
| Distinct Bathrooms Ashbourne Limited | Wholesale & retail | 2018 |
| Dixey Properties Ltd | Real estate | 2021 |
| DJ Ball Garage Services Limited | Wholesale & retail | 2025 |
| DJ Ball Haulage Limited | Transport & logistics | 2012 |
| DJG Training Services Limited | Education | 2024 |
| DKA Commercial Limited | Construction | 2002 |
| DKA Environmental Limited | Real estate | 2024 |
| Dkmd Holdings Ltd | Arts & recreation | 2021 |
| Dkmd Role Play Villages Ltd | Construction | 2022 |
| Dmbi Solutions Ltd | Information & communication | 2025 |
| Dog Desk Animal Action CIC | Education | 2021 |
| Donum Holdings Ltd | Extraterritorial | 2020 |
| Dorothy Flude Retail Park Management Company Limited | Real estate | 2021 |
| Dove Computer Solutions Limited | Other services | 2004 |
| Dove Fields Ltd | Agriculture & fishing | 2023 |
| Dove Property (United Kingdom) Limited | Real estate | 2011 |
| Dove QS Ltd | Professional & scientific | 2020 |
| Dove Valley Group Limited | Financial services | 2009 |
| Dove Valley Park Limited | Real estate | 1992 |
| Dove Valley Plant Limited | Administrative & support | 2008 |
| Dovedale Maintenance Limited | Administrative & support | 2017 |
| Dovelin Cars Ltd | Transport & logistics | 2010 |
| Dragon's Hoard Ltd | Wholesale & retail | 2023 |
| Dream Floor Control Limited | Professional & scientific | 2023 |
| Driftwood Shaper Ltd | Manufacturing | 2017 |
| Drumbeat Capital Limited | Administrative & support | 2024 |
| Dtma Cleaning LLP | | 2016 |
| Dtma Farms Limited | Real estate | 2026 |
| Dtma Holdings Limited | Real estate | 2019 |
| Dtma Limited | Real estate | 2022 |
| DTS Contracting Ltd | Construction | 2025 |
| Dukes Haulage Ltd | Transport & logistics | 2025 |
| Durham Land Limited | Real estate | 1987 |
| Dust Free HAY Limited | Wholesale & retail | 2015 |
| DV8 Stunts Limited | Arts & recreation | 2016 |
| DWB Agricultural Services Limited | Agriculture & fishing | 2016 |
| DWR Mottershead Limited | Manufacturing | 2009 |
| DXT Consulting Limited | Information & communication | 2025 |
| Dytrast Agencies Limited | Wholesale & retail | 2021 |
| E M a Technology Ltd. | Information & communication | 1992 |
| Earl Grey GC Limited | Hospitality | 2021 |
| East Midlands Distribution Centre Limited | Real estate | 2005 |
| East Midlands Hand Therapy Ltd | Health & social care | 2020 |
| East Viking Way Management Company Limited | Real estate | 2024 |