| Spectrum Hair Limited | Other services | 2003 |
| Spectrum Site Group Limited | Financial services | 2024 |
| Spectrum Site Services Limited | Administrative & support | 2014 |
| Spedball Ltd | Manufacturing | 2013 |
| Speech Therapy South Manchester Ltd | Health & social care | 2017 |
| Speedwell IC Limited | Financial services | 2024 |
| Speedwell MC Limited | Financial services | 2024 |
| Spektor Energy Limited | Professional & scientific | 2024 |
| Spencelooker Recruitment Limited | Administrative & support | 2004 |
| Spencer Rowe Insolvency Ltd | Other services | 2018 |
| Spencers Estate Agents Limited | Professional & scientific | 1982 |
| Spengling Ltd | Real estate | 2018 |
| SPG Technologies Ltd | Financial services | 2021 |
| Spice International Trading Company Limited | Wholesale & retail | 2018 |
| Spice Manchester Limited | Other services | 2008 |
| Spice Property Group Limited | Real estate | 2025 |
| Spicer Technologies Ltd | Information & communication | 2026 |
| Spineworx Limited | Health & social care | 2024 |
| Spiretop Ltd | Financial services | 2026 |
| Spirit Logistics Ltd | Transport & logistics | 2020 |
| Spirosense Ltd | Health & social care | 2026 |
| Spitfire Audio Holdings Limited | Information & communication | 2015 |
| SPJ Construction Ltd | Construction | 2019 |
| Splash Art by BEN Ltd | Arts & recreation | 2021 |
| Split Research UK LLP | | 2025 |
| SPM Contracting Services Ltd | Construction | 2016 |
| Spmc Holdings Ltd | Financial services | 2023 |
| Spmc Property Ltd | Real estate | 2020 |
| Spolia Therapeutics UK Limited | Professional & scientific | 2025 |
| Sport Fashion Distribution U.K. Ltd | Wholesale & retail | 2014 |
| Sportfive UK Ltd | Professional & scientific | 1998 |
| Sports DOC Limited | Health & social care | 2014 |
| Sportsmaxx Ltd | Wholesale & retail | 2015 |
| Sporttrack.Ai Limited | Information & communication | 2024 |
| Spotless Ladybirds Cleaning Services Ltd | Administrative & support | 2022 |
| Spotlight GRC Consulting Limited | Professional & scientific | 2025 |
| SPP Global Apparel Ltd | Wholesale & retail | 2026 |
| Sprayit Limited | Manufacturing | 2014 |
| Spring Change Consultancy Limited | Administrative & support | 2014 |
| Spring City Ltd | Arts & recreation | 2014 |
| Spring Clinical Consulting Ltd | Health & social care | 2023 |
| Spring House (Hale) Management Company Limited | Households | 1998 |
| Springbank Property Limited | Real estate | 2000 |
| Springfield House (Prestbury) Holdings Limited | Financial services | 2020 |
| Springfield House (Prestbury) Management Company Ltd | Households | 2016 |
| Springsoflife Ltd | Real estate | 2025 |
| Springtime Investments Limited | Real estate | 2013 |
| Sprintpilot Limited | Professional & scientific | 2022 |
| Sptrtst Ltd | Arts & recreation | 2026 |
| Spurling & Co Limited | Professional & scientific | 2010 |
| Sputnik Properties Ltd | Financial services | 2018 |
| SPV GPC 3 Ltd | Energy | 2023 |
| SQ Business Limited | Real estate | 2018 |
| SQA Info Ltd | Information & communication | 2013 |
| Square 4 Services Limited | Construction | 2016 |
| Square PEG Legal Solutions Limited | Administrative & support | 2011 |
| SR and RJ Medical Ltd | Professional & scientific | 2023 |
| SRB Engineering & Commissioning Limited | Administrative & support | 2008 |
| SRC Realty Holdings Ltd | Real estate | 2026 |
| Sreetari Ltd | Hospitality | 2025 |
| SRI Gruha Ltd | Real estate | 2023 |
| SRI Nilaya Limited | Real estate | 2025 |
| Srimads Consultancy Limited | Administrative & support | 2016 |
| Srise UK Ltd | Information & communication | 2022 |
| SRL Manchester Limited | Real estate | 2019 |
| SRM Innovative Properties Ltd | Real estate | 2023 |
| Srmt Ltd | Arts & recreation | 2022 |
| Sroe Opco Limited | Administrative & support | 2024 |
| Sroe Opco MIP LLP | | 2025 |
| Sroe Propco MIP LLP | | 2025 |
| SS Contract Management Solutions Limited | Professional & scientific | 2022 |
| SS. Extra Time Ltd | Arts & recreation | 2018 |
| Ssae Developments Limited | Construction | 2023 |
| Sscn Solutions Limited | Information & communication | 2022 |
| SSD Consulting Limited | Professional & scientific | 2022 |
| SSH Trading Group Ltd | Wholesale & retail | 2019 |
| SSL Newco 001 Ltd | Information & communication | 2023 |
| Ssns Solutions Limited | Professional & scientific | 2021 |
| SSQ Pharma Ltd | Health & social care | 2014 |
| Ssrp Investment Ltd | Real estate | 2021 |
| Ssrs Retail Ltd | Wholesale & retail | 2025 |
| Ssruk Consulting Limited | Administrative & support | 2015 |
| ST Andrews Court Ltd | Real estate | 2013 |
| ST Annes Music Limited | Other services | 1971 |
| ST Austell Investments Limited | Real estate | 2017 |
| ST Austin's Court (Warrington) Management Company Limited | Households | 2005 |
| ST Brides Garage Limited | Wholesale & retail | 2024 |
| ST Georges Associates Limited | Information & communication | 2022 |
| ST James Court Residents Company Limited | Households | 1999 |
| ST James Park Residents Management Company Limited | Households | 2016 |
| ST James Park Southsea Residents Management Company Limited | Households | 2025 |
| ST John's Court (Altrincham) Limited | Households | 1995 |
| ST Mary's Development (York) Ltd | Construction | 2024 |
| ST Mary's Hall Management Company Limited | Hospitality | 2004 |
| ST Netherlands Ltd | Professional & scientific | 2012 |
| ST Paul's NO 1 Management Company Limited | Households | 2006 |
| ST Resourcing Limited | Administrative & support | 2017 |
| ST Stephens Birmingham Ltd | Financial services | 2026 |
| ST. Ambrose College Edmund Rice Academy Trust | Education | 2011 |
| ST. Cyprian’S RTM Company (Edgehill) Limited | Households | 2018 |