| Derwent Fabrications Ltd | Manufacturing | 2023 |
| Derwent Industrial Services Limited | Manufacturing | 2024 |
| Derwent Joinery & Property Renovations Ltd | Construction | 2024 |
| DFY Social Ltd | Professional & scientific | 2022 |
| DGB Solutions Limited | Wholesale & retail | 2019 |
| DGM Agility Limited | Information & communication | 2019 |
| Dicom Premier Limited | Manufacturing | 1981 |
| Digismiles Ltd | Education | 2023 |
| Digita Media Ltd | Professional & scientific | 2023 |
| Digital Skills People Ltd | Other services | 2018 |
| Diivine Ltd | Wholesale & retail | 2026 |
| Dinki Donki Limited | Manufacturing | 2019 |
| Direct Independent Imports Limited | Wholesale & retail | 2013 |
| Direct Wrapping Company Ltd | Wholesale & retail | 2024 |
| DJ Billy's Entertainment Events Ltd | Arts & recreation | 2024 |
| DJP Technology Limited | Manufacturing | 2024 |
| DJR Construction Services Ltd | Construction | 2019 |
| Djscarfe Limited | Information & communication | 2025 |
| DJW Associates Limited | Professional & scientific | 2025 |
| DMA Electrical Services (Midlands) Ltd | Construction | 2024 |
| DMB Fencing &ARB Ltd | Construction | 2019 |
| DMV Logistics Ltd | Transport & logistics | 2019 |
| DNF Coaching Limited | Arts & recreation | 2013 |
| Dntaylor Plumbing & Heating Ltd | Construction | 2023 |
| Dog and Spoon Distillery Ltd | Manufacturing | 2019 |
| Dog and Spoon Ltd | Hospitality | 2014 |
| Doleman Ltd | Construction | 2021 |
| Done for YOU Limited | Professional & scientific | 2023 |
| Doublepp Sanctuary Care Ltd | Health & social care | 2025 |
| DPA Motors Limited | Wholesale & retail | 2011 |
| Dreams Coffee and Deli Ltd | Hospitality | 2026 |
| Driver Development Limited | Education | 2026 |
| DRO & Machine Parts Ltd | Manufacturing | 2018 |
| Drogocom Limited | Extraterritorial | 2022 |
| DS Bespoke Furniture Ltd | Manufacturing | 2022 |
| DS Greenwright Limited | Wholesale & retail | 2016 |
| Duke Consultancy Ltd | Professional & scientific | 2025 |
| Dukeries Investments Limited | Real estate | 1982 |
| Dupe Selling Ltd | Wholesale & retail | 2026 |
| Duplex Lift Services Ltd | Professional & scientific | 2020 |
| Dutch Haus Limited | Construction | 2022 |
| DW Gold Trading Ltd | Education | 2026 |
| DWF Driveways Ltd | Construction | 2016 |
| Dylbobz Estates Limited | Real estate | 2023 |
| Dylbobz Limited | Information & communication | 2022 |
| Dynamic Electrix Ltd | Construction | 2009 |
| E and T Ltd | Hospitality | 2003 |
| E Fell Ltd | Financial services | 2024 |
| E Liquid Stores Limited | Wholesale & retail | 2016 |
| E.I.R.P Limited | Real estate | 1994 |
| Early Years Fundamentals Ltd | Education | 2017 |
| East Finchley Catering Limited | Hospitality | 2008 |
| East Midlands Care Matters Limited | Health & social care | 2007 |
| East Midlands Developments Limited | Real estate | 1984 |
| East Midlands Integrated Healthcare Ltd | Health & social care | 2017 |
| Easy Property Rentals Ltd | Real estate | 2026 |
| Easypaye Payroll Services Ltd | Professional & scientific | 2018 |
| EAT Ofton Ltd | Wholesale & retail | 2026 |
| Ebeniste Furniture Limited | Manufacturing | 2016 |
| EBS Valeters Limited | Wholesale & retail | 2016 |
| Eco Paint UK Ltd | Manufacturing | 2021 |
| Eco Vape Limited | Manufacturing | 2014 |
| Eco Vape Stores Limited | Wholesale & retail | 2016 |
| Ecoplas Limited | Water & waste | 1997 |
| Edryn Limited | Hospitality | 2012 |
| Edsl Limited | Transport & logistics | 2002 |
| Educate & Create Ltd | Education | 2026 |
| Efficiency East Midlands Limited | Professional & scientific | 2011 |
| Eggsakimbo Limited | Hospitality | 2026 |
| EJ Holidays and Lettings Ltd | Real estate | 2023 |
| EJ Taylor Limited | Professional & scientific | 2007 |
| Ejlt Limited | Wholesale & retail | 2019 |
| EKS Geoscience Ltd | Water & waste | 2011 |
| EL & JB Property Ltd | Real estate | 2025 |
| Electrical Mechanical Services Limited | Construction | 2015 |
| Electricmover Ltd | Construction | 2010 |
| Electrotech (UK) Ltd | Construction | 2011 |
| Elements Live Lounge Ltd | Hospitality | 2025 |
| Eleven Eleven Security Solutions Ltd | Construction | 2019 |
| Elhealth UK Ltd | Health & social care | 2025 |
| Elite Brickwork & Joinery Limited | Construction | 2025 |
| Elite Build Interiors Ltd | Construction | 2023 |
| Elite Fire Safety Services Ltd | Administrative & support | 2016 |
| Elite Kickz Football Coaching Ltd | Other services | 2025 |
| Elite Lets Limited | Real estate | 2025 |
| Elite Material Handling Limited | Manufacturing | 2011 |
| ELK Property Holdings Ltd | Real estate | 2018 |
| ELK Roofing and Construction Ltd | Construction | 2020 |
| Elliott Group Limited | Extraterritorial | 2023 |
| Elliott Property Solutions Limited | Extraterritorial | 2023 |
| Elmir Transport Ltd | Transport & logistics | 2023 |
| Elms Contracting Ltd | Agriculture & fishing | 2016 |
| ELW Property Ltd | Real estate | 2024 |
| EM Recycling (Derbys) Ltd | Construction | 2024 |
| Empire of Play Ltd | Wholesale & retail | 2025 |
| Empowered Warrior Candle Company Ltd | Wholesale & retail | 2025 |
| Emre Baran Ltd | Hospitality | 2025 |
| Enchanted Rose Weddings and Events Limited | Administrative & support | 2023 |
| Energy Impact Consulting Limited | Professional & scientific | 2026 |
| Energy Procurement Management Consultancy Limited | Professional & scientific | 2020 |