| Samosa Pakora Films Limited | Professional & scientific | 2025 |
| Samsun Solutions Ltd | Information & communication | 2018 |
| Sanba Property Limited | Real estate | 2021 |
| Sanchez Personal Training Ltd | Arts & recreation | 2021 |
| Sandhurst Autoprint Limited | Manufacturing | 1997 |
| Sane Health & Safety Ltd | Professional & scientific | 2020 |
| Santa’S Sweats Ltd | Wholesale & retail | 2024 |
| Santei Studios Limited | Wholesale & retail | 2024 |
| Sanvi & Co Ltd | Wholesale & retail | 2021 |
| Sanvi Jewellers Ltd | Wholesale & retail | 2022 |
| Sanya Convenience Store Ltd | Wholesale & retail | 2016 |
| SAP Group Properties Limited | Real estate | 2016 |
| Sapphire 333 Limited | Professional & scientific | 2023 |
| Saracen Group Limited | Administrative & support | 2019 |
| Sarah Jean Packman Limited | Administrative & support | 2025 |
| Saraswati Jewellers & Co Ltd | Wholesale & retail | 2020 |
| Saraswati Property Ltd | Construction | 2026 |
| Sarax Limited | Construction | 2002 |
| Sarm Estates Ltd | Real estate | 2025 |
| SAS Stone Worktops Ltd | Construction | 2021 |
| Saska Grove Consulting Limited | Administrative & support | 2021 |
| Satelliet (UK) Limited | Wholesale & retail | 1992 |
| Savannah Ward Ltd | Administrative & support | 2020 |
| Savour Cakes Limited | Manufacturing | 2025 |
| SBH Airport Taxi Limited | Transport & logistics | 2025 |
| Sbtg Ltd | Construction | 2026 |
| SC Carter Limited | Transport & logistics | 2014 |
| SC Moorings Ltd | Manufacturing | 2018 |
| Scaffolding PL Ltd | Construction | 2019 |
| Scallywags Dog Services Ltd | Other services | 2014 |
| Scanfit Trail Ltd | Health & social care | 2025 |
| Scare Friday 13TH Ltd | Professional & scientific | 2007 |
| Scomac EOT Ltd | Financial services | 2023 |
| Scomac Services Ltd | Construction | 1998 |
| Scott Butler Sports Massage Ltd | Extraterritorial | 2023 |
| Scott Hart Limited | Professional & scientific | 2012 |
| Scratch 12 Ltd | Construction | 2020 |
| Scully Electrics Ltd | Administrative & support | 2016 |
| Se&L Limited | Professional & scientific | 2025 |
| Sea Safe Limited | Transport & logistics | 2024 |
| Sealfix Roofing and Construction Ltd | Construction | 2024 |
| Second JOB HR Ltd | Administrative & support | 2026 |
| Securikey Limited | Wholesale & retail | 2001 |
| Seesoni Ltd | Wholesale & retail | 2024 |
| Seffo Limited | Wholesale & retail | 2020 |
| Selimi Properties Ltd | Real estate | 2025 |
| Semper Paratus Limited | Administrative & support | 2024 |
| Sener's Fencing & Landscaping Limited | Professional & scientific | 2023 |
| Sensabilitykidsot Ltd | Public administration | 2025 |
| Seren Kids Ltd | Education | 2022 |
| Seren Sports Limited | Education | 2025 |
| Serendib Sustainability Ventures UK Ltd | Financial services | 2025 |
| Serenity by Smith Ltd | Health & social care | 2024 |
| Serenity Home Caring Limited | Health & social care | 2024 |
| Serenity Skin Aesthetic's Ltd | Other services | 2003 |
| Serenity Soul Psychic Fayres Ltd | Administrative & support | 2024 |
| Services at Home Ltd | Administrative & support | 2009 |
| Session Zero Consulting Limited | Information & communication | 2026 |
| Sewa Housing Ltd | Real estate | 2025 |
| SFM2 Studio Ltd | Construction | 2025 |
| SG Reid Investments Ltd | Financial services | 2023 |
| Shaafi Ltd | Real estate | 2024 |
| Shaban Halal Food Ltd | Wholesale & retail | 2016 |
| Shadow Investment Ltd | Real estate | 2024 |
| Shakeelabibi Ltd | Wholesale & retail | 2025 |
| Shakti Ghar Ltd | Real estate | 2020 |
| Shakun Fashion House Ltd | Wholesale & retail | 2017 |
| Shamrock Aviation Services Ltd | Transport & logistics | 2019 |
| Shamz Beauty Ltd | Other services | 2026 |
| Shanti Deep Ltd | Real estate | 2025 |
| Shanti Hair & Beauty Ltd | Other services | 2024 |
| Share Ride Ltd | Information & communication | 2023 |
| Sharp Building and Construction Ltd | Construction | 2026 |
| Sharpscapes Ltd | Administrative & support | 2025 |
| Shaw Preservations Limited | Construction | 1980 |
| Shawnharry Consulting Limited | Information & communication | 2011 |
| SHE Strides Events Limited | Other services | 2026 |
| Shebs Holdings Ltd | Real estate | 2024 |
| Sheeling Close Management Company Limited | Households | 2015 |
| Sheet Tech Fabrications Limited | Manufacturing | 2016 |
| Shift Time Focus Ltd | Administrative & support | 2026 |
| Shiny Wheel Specialist Ltd | Wholesale & retail | 2025 |
| Shiva Takeaway Ltd | Hospitality | 2026 |
| Shivashankar Ltd | Hospitality | 2023 |
| Shona Dombo Ltd | Wholesale & retail | 2023 |
| Shonika Limited | Hospitality | 2022 |
| Shop Inn Ltd | Wholesale & retail | 2022 |
| Shree Agrawal Travels and Tours Ltd | Wholesale & retail | 2024 |
| Shree Lucky Jewellery PVT Ltd | Wholesale & retail | 2015 |
| Shree Lucky Jewellery S Limited | Wholesale & retail | 2025 |
| Shuffles Limited | Other services | 2002 |
| Shuvakamana Ltd | Wholesale & retail | 2012 |
| Sibystudio Limited | Professional & scientific | 2015 |
| Siennasavvy Limited | Professional & scientific | 2025 |
| SIF Consulting Ltd | Professional & scientific | 2023 |
| Signal Solutions Surrey Ltd | Construction | 2021 |
| Silk Industries Ltd | Manufacturing | 2025 |
| Silk Renovation Ltd | Real estate | 2026 |
| Silver Dollar Training Ltd | Arts & recreation | 2025 |
| Simbha Catering Ltd | Hospitality | 2026 |