| Smart Master Limited | Wholesale & retail | 2011 |
| Smart Rides Transport Ltd | Transport & logistics | 2025 |
| Smart Tech Hire Limited | Administrative & support | 2023 |
| Smart Trader Services Ltd | Wholesale & retail | 2020 |
| Smartt Fashion Limited | Wholesale & retail | 2025 |
| Smartword (Global) Ltd | Professional & scientific | 2016 |
| Smash & EAT Ltd | Hospitality | 2023 |
| Smashie's Crawshawbooth Ltd | Hospitality | 2025 |
| SMB BSL Limited | Professional & scientific | 2018 |
| Smith Social Media Services Ltd | Information & communication | 2025 |
| Smith's Merchandise Ltd | Wholesale & retail | 2017 |
| Smokehouse 138 Ltd | Hospitality | 2018 |
| Smooth Removals Ltd | Transport & logistics | 2025 |
| Snapco Ltd | Wholesale & retail | 2025 |
| SNOOKER47 Ltd | Arts & recreation | 2025 |
| Snooty FOX Vintage Limited | Wholesale & retail | 2017 |
| Snowdrop Doula Community Interest Company | Education | 2014 |
| Socialflame Limited | Information & communication | 2026 |
| Sofa MAX Limited | Wholesale & retail | 2017 |
| Softklik Ltd | Wholesale & retail | 2026 |
| SOJ Painting and Cleaning Services Ltd | Construction | 2025 |
| Sole Solution Footwear Limited | Wholesale & retail | 2017 |
| Solid Liquid Media Group Ltd | Information & communication | 2022 |
| Solidbud Ltd | Construction | 2024 |
| Solutions Spot Limited | Financial services | 2024 |
| Soundsureapp Ltd | Information & communication | 2025 |
| Sovereign Merchants Ltd | Wholesale & retail | 2026 |
| Sovereign Secure Limited | Other services | 2012 |
| Sovereign Snooker Supplies Limited | Wholesale & retail | 2022 |
| Soyang Europe Limited | Wholesale & retail | 2005 |
| Soyang Hardware Limited | Other services | 2008 |
| Soyang Technologies EU Limited | Professional & scientific | 2005 |
| Sparkle JET Wash Services Limited | Administrative & support | 2023 |
| Sparthfield Happy Day Nursery Limited | Health & social care | 2006 |
| Sparthfield Holdings Ltd | Financial services | 2026 |
| Special Futures (Holdings) Limited | Financial services | 2017 |
| Special Futures Limited | Extraterritorial | 2017 |
| Specialist Breakers Limited | Real estate | 2011 |
| Specialist Diesel Ltd | Wholesale & retail | 2000 |
| Specialist Primary Care Services Ltd | Health & social care | 2022 |
| Specialist Training & Consultancy Services Ltd | Education | 1999 |
| Spectrair Limited | Professional & scientific | 2020 |
| Spen Assets Limited | Real estate | 2024 |
| Spencer News Limited | Wholesale & retail | 2019 |
| Spice Cinnamon Ltd | Hospitality | 2025 |
| Spire Court Properties Ltd | Construction | 2016 |
| Spire Parts Lancashire Ltd | Wholesale & retail | 2023 |
| Sports Therapy Organisation Limited | Other services | 2018 |
| Sports Turf Essentials Ltd | Wholesale & retail | 2019 |
| Spotless Hunters Ltd | Administrative & support | 2025 |
| Spoton Travel Limited | Administrative & support | 2015 |
| Springhill Community Centre Ltd. | Education | 2004 |
| Sprint Clean Ltd | Administrative & support | 2024 |
| Spud Cafe Ltd | Hospitality | 2026 |
| SR Emporium Ltd | Wholesale & retail | 2022 |
| SRS Catering Ltd | Hospitality | 2014 |
| ST John's C.E. Preschool Ltd | Education | 2023 |
| ST Paul's Street MOT Centre Ltd | Wholesale & retail | 2023 |
| Staniec Transport Limited | Transport & logistics | 2013 |
| Stanley Estates and Lettings Ltd | Real estate | 2016 |
| Stanten Properties Limited | Construction | 2021 |
| Star Garage & Tyre Centre Ltd | Wholesale & retail | 2026 |
| Starmode Networks Limited | Financial services | 2011 |
| Starross Ltd | Hospitality | 2025 |
| Stars of Joy Limited | Wholesale & retail | 2025 |
| Station Garage (Accrington) Limited | Other services | 2012 |
| STC Services (Plant Hire) Limited | Construction | 2002 |
| Stellify Solutions Ltd | Construction | 2025 |
| Step by Step Footprints Community Interest Company | Wholesale & retail | 2025 |
| Stephen George Accountants Limited | Professional & scientific | 2003 |
| Stephen Metcalf Limited | Administrative & support | 1984 |
| Steps Residential Care Limited | Health & social care | 1999 |
| Steptoes Yard Limited | Manufacturing | 2006 |
| Stilldepth Community CIC | Education | 2026 |
| Stirkridge Ltd | Real estate | 2026 |
| Stone Active Developments Ltd | Administrative & support | 2018 |
| Stonevail Construction Ltd | Construction | 2024 |
| Stoneywell Limited | Real estate | 2016 |
| Stormd Worldwide Ltd | Wholesale & retail | 2026 |
| Stratagem Resources Limited | Professional & scientific | 2025 |
| Stratify Minds Limited | Administrative & support | 2024 |
| Stronghold Property Solutions Ltd | Real estate | 2025 |
| Stryd Visuals Ltd | Information & communication | 2025 |
| STS Live Events Ltd | Hospitality | 2026 |
| Style Kitchens (NW) Ltd | Manufacturing | 2020 |
| Styled by Emily Ltd | Other services | 2022 |
| Subjayas Ltd | Wholesale & retail | 2017 |
| Sultana Foods Ltd | Wholesale & retail | 2024 |
| Sunlight UK Energy Ltd | Administrative & support | 2023 |
| Sunnivision Ltd | Real estate | 2020 |
| Sunset Communications Limited | Administrative & support | 2024 |
| Super Hand Car Wash (Accrington) Ltd | Administrative & support | 2018 |
| Super Hand Fast Carwash Limited | Administrative & support | 2025 |
| Support Where Matters Ltd | Professional & scientific | 2025 |
| Supportech Limited | Information & communication | 2023 |
| SURGE7 Group Limited | Wholesale & retail | 2023 |
| Suryia Care Limited | Health & social care | 2025 |
| Sustenance NW Ltd | Hospitality | 2022 |
| Svrt Ltd | Health & social care | 2022 |
| Swaadesh North West Ltd | Hospitality | 2025 |