| SAL Property Services Limited | Professional & scientific | 2010 |
| Salamart Ltd | Wholesale & retail | 2010 |
| Sally Riley Ltd | Professional & scientific | 2016 |
| Salon Business Solutions Ltd | Administrative & support | 2020 |
| SAM Autos MOT & Repair Centre Ltd | Wholesale & retail | 2019 |
| SAN Giuseppe Pizza Co Ltd | Hospitality | 2025 |
| Sand Dollar Holdings Limited | Financial services | 2019 |
| Sanderson Stone Limited | Wholesale & retail | 2013 |
| Sanderson's Butchers Ltd | Wholesale & retail | 2009 |
| Sandstone Building Services Limited | Construction | 2016 |
| Sapient Minds Ltd | Health & social care | 2020 |
| Sattar & Co. Limited | Information & communication | 1990 |
| Save and Raise Ltd | Administrative & support | 2009 |
| Savpaj Real Estate Investments Ltd | Real estate | 2024 |
| Sbs-Hair.Com Ltd | Administrative & support | 2020 |
| Scaitcliffe PO Ltd | Wholesale & retail | 2025 |
| Scandicandy Ltd | Wholesale & retail | 2025 |
| Scentuality Limited | Wholesale & retail | 2025 |
| Sdam Lancs Limited | Construction | 2025 |
| Seal Properties & Investments Ltd | Real estate | 2025 |
| Sean O'Toole Limited | Construction | 2003 |
| Seaville Retreat Ltd | Hospitality | 2026 |
| Securecore UK Ltd | Administrative & support | 2026 |
| Securitech Solutions Ltd | Administrative & support | 2020 |
| Security 247 Plus Ltd | Information & communication | 2008 |
| Securostore Holdings Ltd | Real estate | 2019 |
| Securostore Home Storage Ltd | Real estate | 2009 |
| Securostore Trade Storage Ltd | Transport & logistics | 2009 |
| SEL Holdings Co Ltd | Financial services | 2026 |
| Selectaspex Factory Eyewear Direct Ltd | Wholesale & retail | 2020 |
| Sell 8 Limited | Wholesale & retail | 2012 |
| Sell Your Gadget Ltd | Information & communication | 2025 |
| Senator International Limited | Manufacturing | 1977 |
| Senator Leisure Products Limited | Professional & scientific | 1980 |
| Senator Systems International Limited | Professional & scientific | 1985 |
| Sensory Street Ltd | Wholesale & retail | 2025 |
| Sentinel Fire & Security Ltd | Construction | 2024 |
| Serenallce Limited | Hospitality | 2024 |
| Service Solutions (NW) Ltd | Professional & scientific | 2016 |
| Service Wash 4 U Limited | Other services | 2025 |
| Sesar Ltd | Information & communication | 2025 |
| SEVEN7EENTCG Limited | Wholesale & retail | 2025 |
| Seventy BOB Barbers Limited | Other services | 2012 |
| Sewing Hymns Limited | Real estate | 2020 |
| SH Medcare Ltd | Health & social care | 2023 |
| Shaamikh Ltd | Wholesale & retail | 2025 |
| Shadow Property Ltd | Construction | 2023 |
| Shah Joli Catering Ltd | Hospitality | 2018 |
| Shahicollection Ltd | Wholesale & retail | 2025 |
| Shahzad Investments Limited | Real estate | 2019 |
| Shally Limited | Wholesale & retail | 2025 |
| Sham Sharif Ltd | Hospitality | 2019 |
| Shamz Motors Ltd | Wholesale & retail | 2025 |
| Shapedwoodn Ltd | Manufacturing | 2026 |
| Shapes Gym Limited | Health & social care | 2014 |
| Sharden Trading Limited | Arts & recreation | 1992 |
| Sharp Estate Agents & Lettings Ltd | Real estate | 2009 |
| Sharp Letting & Property Management Limited | Real estate | 2013 |
| Sharron Mercer Advanced Practitioner Ltd | Health & social care | 2021 |
| Sharwet Limited | Other services | 2023 |
| SHD Housing Limited | Real estate | 2018 |
| Shed Monkey Ltd | Wholesale & retail | 2016 |
| Shelton Care Limited | Education | 1995 |
| Shipaling Limited | Wholesale & retail | 2026 |
| SHK Colmore Ltd | Hospitality | 2025 |
| Shokey Vape Ltd | Wholesale & retail | 2026 |
| Shortkoot Ltd | Information & communication | 2021 |
| Shuttles Courier Limited | Transport & logistics | 2024 |
| SI Ground Investigation Limited | Construction | 2022 |
| Signature Oak Retreats Holdings Limited | Financial services | 2026 |
| Signature Oak Retreats Ltd | Hospitality | 2022 |
| Sika Metallo Limited | Financial services | 2016 |
| Silverwoods Holdings Ltd | Financial services | 2017 |
| Silverwoods Waste Management (Holdings) Limited | Financial services | 2025 |
| Silverwoods Waste Management Ltd | Water & waste | 2010 |
| Simonstone Estate Limited | Financial services | 2015 |
| Simple Estates Limited | Administrative & support | 2024 |
| Simple Gifts Ltd | Wholesale & retail | 2018 |
| Simply Letting (NW) Ltd | Real estate | 2012 |
| Singer Motors Limited | Manufacturing | 2014 |
| SIR Business and Enterprise Limited | Information & communication | 2012 |
| SIS Investments Ltd | Administrative & support | 2017 |
| Sistitude CIC | Health & social care | 2025 |
| Siya Trading Ltd | Wholesale & retail | 2024 |
| SJ Developments Ltd | Public administration | 2012 |
| SJA (North West) Limited | Real estate | 2008 |
| SJA Film Convertors Ltd | Manufacturing | 2023 |
| SJA Holdings (NW) Limited | Financial services | 2026 |
| SJL Accountancy Limited | Professional & scientific | 2014 |
| SKI Trading Ltd | Other services | 2019 |
| Skills for Safety Ltd | Education | 2024 |
| SKR Pubs Groups Ltd | Hospitality | 2025 |
| Skyboardmedia Limited | Professional & scientific | 2025 |
| Slate Hospitality Limited | Hospitality | 2013 |
| Slone Properties Limited | Real estate | 2022 |
| Slsl Transport Ltd | Transport & logistics | 2025 |
| Small Business Software Ltd | Information & communication | 2024 |
| Small Pebbles Limited | Real estate | 2021 |
| Smart ALL Solutions (NW) Limited | Financial services | 2023 |
| Smart Building Solutions Blackburn Ltd | Administrative & support | 2019 |