| ED Heaton Limited | Other services | 2021 |
| Edbury Contract Solutions Ltd | Professional & scientific | 2014 |
| Eddie & Co Yorkshire Ltd | Real estate | 2024 |
| Eddie Clarke Personal Training Ltd | Arts & recreation | 2025 |
| Eddy Adams Consultants Limited | Professional & scientific | 2001 |
| Eddy Stunts Limited | Information & communication | 2022 |
| Eden 5 (Consultancy) Limited | Professional & scientific | 2023 |
| Eden Global Associates Worldwide Ltd | Administrative & support | 2015 |
| Eden Rock Estates Limited | Construction | 2006 |
| Eden SAP Services Ltd | Professional & scientific | 2020 |
| Eden Taverns Ltd | Hospitality | 2025 |
| Edens Heating and Plumbing Limited | Construction | 2017 |
| Edens Nest Properties Ltd | Real estate | 2026 |
| Edenvale Homes (York) Ltd | Construction | 2001 |
| Edge Event Management UK Ltd | Arts & recreation | 2021 |
| Edge Services - the Manual Handling Training Company Limited | Professional & scientific | 1999 |
| Edge Windows Ltd | Manufacturing | 2022 |
| EDGE45 Industries Limited | Financial services | 2018 |
| EDGE45 Limited | Other services | 2015 |
| Edgewater Firth Limited | Extraterritorial | 2026 |
| Edinburgh Swim School LLP | | 2024 |
| Edlin Dental Limited | Health & social care | 2023 |
| Edlin Dental Property Limited | Real estate | 2025 |
| Edmeston Purdy Ltd | Education | 2026 |
| Edmund Jackson (Leeds) Limited | Real estate | 1938 |
| Edmund Optics Ltd. | Wholesale & retail | 1998 |
| Edmund Scientific Limited | Professional & scientific | 2000 |
| Education Sport Play Limited | Extraterritorial | 2012 |
| Education Together Ltd | Education | 2017 |
| Edward & Armstrong Limited | Hospitality | 2025 |
| Edwards Bathrooms (York) Limited | Construction | 2019 |
| Edwards Oliver Management Limited | Administrative & support | 2007 |
| Edwards Plumbing (York) Limited | Construction | 2019 |
| EEC Contracting Ltd | Construction | 2023 |
| Effective Mentoring Ltd | Professional & scientific | 2023 |
| Efficient Buildings Limited | Professional & scientific | 2003 |
| Effort Wins Ltd | Wholesale & retail | 2025 |
| Effortless Bookkeeping Limited | Professional & scientific | 2022 |
| Eggenuity Limited | Agriculture & fishing | 2024 |
| Eggs Holdco Limited | Real estate | 2022 |
| EGS Solutions Ltd | Professional & scientific | 2022 |
| EHL York Limited | Real estate | 2020 |
| EHR Hospitality Limited | Hospitality | 2025 |
| Eiat Consultancy Limited | Education | 2006 |
| Eiger HM Limited | Professional & scientific | 2015 |
| Eighteen ST. Mary's (York) Limited | Households | 1982 |
| Eighty Twenty Developments Limited | Construction | 2024 |
| Eisley Ltd | Manufacturing | 2016 |
| Either Way UP Ltd | Hospitality | 2025 |
| EJ Roofing Lancashire Ltd | Construction | 2024 |
| EJJ28 Ltd | Arts & recreation | 2021 |
| EJL Roofing Residential Ltd | Construction | 2023 |
| EJM International Ltd | Professional & scientific | 2024 |
| EJM Legal Services Ltd | Administrative & support | 2020 |
| EJM Transport Services Limited | Other services | 2022 |
| EJS Electrical Contractors Ltd | Construction | 2015 |
| EKO Create UK Limited | Information & communication | 2014 |
| EL Gaucho Steakhouse Ltd | Hospitality | 2013 |
| Elaine Graham Limited | Professional & scientific | 2004 |
| Elan Digital Media Limited | Professional & scientific | 2017 |
| Elantie Limited | Water & waste | 2026 |
| Elarian Estates Ltd | Hospitality | 2026 |
| Elastifit Limited | Wholesale & retail | 2025 |
| Elate Homes Ltd | Health & social care | 2026 |
| Elbon Investments Limited | Financial services | 2015 |
| Elcock Power Tools (Yorkshire) Limited | Extraterritorial | 2000 |
| Elcocks Limited | Manufacturing | 1977 |
| ELD Close Management Limited | Administrative & support | 2017 |
| Electech Northern Ltd | Construction | 2015 |
| Electratech UK Limited | Professional & scientific | 2002 |
| Electric City York Limited | Construction | 1999 |
| Electric Gate Solutions Ltd | Construction | 2021 |
| Electriccore Ltd | Construction | 2024 |
| Electrickall Ltd | Construction | 2009 |
| Electronics Direct EOT Limited | Financial services | 2025 |
| Electronics Direct Holdings Limited | Financial services | 2022 |
| Electronics Direct Limited | Information & communication | 1999 |
| Electrotec Security & Electrical Limited | Administrative & support | 2008 |
| Electrotec Security Limited | Administrative & support | 2017 |
| Elefant Ltd | Hospitality | 2023 |
| Elegant Projects Limited | Construction | 2026 |
| Elegant Stays York Ltd. | Hospitality | 2024 |
| Elemental Brewing Ltd | Manufacturing | 2017 |
| Elemental Workplace Limited | Professional & scientific | 2025 |
| Elements Solutions Ltd | Manufacturing | 2022 |
| Elemma Limited | Extraterritorial | 2011 |
| Elenem Limited | Professional & scientific | 2006 |
| Elephant’S Feast York Ltd | Hospitality | 2025 |
| Elesco Wood Flooring Ltd | Construction | 2024 |
| ELEV8 Children's Homes Ltd | Health & social care | 2025 |
| Elevare Accountants Ltd | Professional & scientific | 2025 |
| Elevate Food Ventures Limited | Manufacturing | 2025 |
| Elevate Tennis Coaching Ltd | Education | 2021 |
| Elevate York Ltd | Arts & recreation | 2025 |
| ELEVEN11 Investments Ltd | Extraterritorial | 2021 |
| Elevus Ltd | Professional & scientific | 2024 |
| Elgenia PM Services Ltd | Professional & scientific | 2015 |
| Elham Wood Limited | Financial services | 2025 |
| Eliam Bros Transport Ltd | Transport & logistics | 2021 |
| Eliments Limited | Manufacturing | 2007 |