| York Occupational Health Solutions Ltd | Health & social care | 2015 |
| York One Ltd | Hospitality | 2019 |
| York Opera Productions Limited | Arts & recreation | 2026 |
| York Osteoarchaeology Ltd | Professional & scientific | 2003 |
| York PA and Student Support Limited | Education | 2011 |
| York Pathology Limited | Health & social care | 2016 |
| York Pavilion Hotel Limited | Other services | 2004 |
| York Personal Support Limited | Health & social care | 2013 |
| York Physio & Health Limited | Health & social care | 2025 |
| York Pink Builder Ltd | Construction | 2024 |
| York Planes LLP | | 2005 |
| York Plastering & Cornice Specialists Ltd | Construction | 2022 |
| York Plumbing & Boilers Limited | Construction | 2021 |
| York Podiatry Limited | Health & social care | 2015 |
| York Powder Coating Limited | Manufacturing | 2017 |
| York Primary Care Properties LLP | | 2020 |
| York Print Limited | Professional & scientific | 2008 |
| York Priory Limited | Hospitality | 2012 |
| York Private Medical Ltd | Health & social care | 2015 |
| York Probe Sources Limited | Manufacturing | 1997 |
| York Proclean Carpets LLP | | 2026 |
| York Professionals | Other services | 2001 |
| York Projects Ltd | Construction | 2020 |
| York Proms Limited | Arts & recreation | 2016 |
| York Property Group Limited | Construction | 2021 |
| York Property Holdings Limited | Real estate | 2016 |
| York Property Investments LLP | | 2009 |
| York Property Lets Ltd | Real estate | 2023 |
| York Property Media Ltd | Professional & scientific | 2023 |
| York Property Services Ltd | Construction | 2024 |
| York Property Solutions Ltd | Administrative & support | 2013 |
| York PUB Development Co Ltd | Construction | 2025 |
| York Publishing Services Limited | Manufacturing | 2022 |
| York Pullman BUS Company Limited | Transport & logistics | 2007 |
| York Pullman Holdings Limited | Professional & scientific | 2009 |
| York Racecourse Knavesmire LLP | | 2007 |
| York Rail Telecoms Limited | Information & communication | 2016 |
| York Reclaimed Slate Company Ltd | Wholesale & retail | 2008 |
| York Regency Associates Ltd. | Wholesale & retail | 2014 |
| York Residential Landlords Association Limited | Other services | 2024 |
| York Rise Limited | Professional & scientific | 2011 |
| York Road Garage Ltd | Wholesale & retail | 2013 |
| York Road Motors (Strensall) Limited | Wholesale & retail | 1973 |
| York Roofing & Guttering Limited | Construction | 2023 |
| York Salvage Ltd | Real estate | 1999 |
| York SBS Food Ltd | Wholesale & retail | 2025 |
| York Science Park Limited | Real estate | 1994 |
| York Self Storage Ltd | Administrative & support | 2017 |
| York Send Advocacy Ltd. | Education | 2026 |
| York Shield Ltd | Administrative & support | 2026 |
| York Sign Company Limited | Manufacturing | 2011 |
| York Sign Services Ltd | Construction | 2023 |
| York Site Services Limited | Wholesale & retail | 2024 |
| York Social Enterprise Coalition C.I.C. | Other services | 2025 |
| York Spice Ltd | Hospitality | 2026 |
| York Sports CIC | Arts & recreation | 2025 |
| York ST John Students' Union | Education | 2010 |
| York Stage Ltd | Other services | 2019 |
| York Station Taxis Ltd | Transport & logistics | 1998 |
| York Student Lettings Limited | Real estate | 2023 |
| York Support Services CIC | Extraterritorial | 2023 |
| York Surplus Building Supplies Ltd | Wholesale & retail | 2021 |
| York Sushi Ltd | Wholesale & retail | 2018 |
| York Swimming Academy Ltd. | Education | 2016 |
| York Synagogue Limited | Other services | 2022 |
| York Syndicate MMA LLP | | 2024 |
| York TAP Limited | Hospitality | 2011 |
| York Teaching Hospital Facilities Management LLP | | 2018 |
| York Tech Guys Ltd | Construction | 2018 |
| York Theatre Productions Ltd | Arts & recreation | 2014 |
| York Theatre Royal Enterprises Ltd | Hospitality | 1994 |
| York Therapy Centre Ltd | Health & social care | 2024 |
| York Tong's Ltd. | Hospitality | 2018 |
| York Townhouses Ltd | Real estate | 2026 |
| York Transmission Supplies Limited | Wholesale & retail | 1983 |
| York Tutoring LLP | | 2025 |
| York Tyre Sales Ltd | Wholesale & retail | 2011 |
| York University Energy Supply Company Limited | Energy | 1993 |
| York University Property Company Limited | Real estate | 1991 |
| York Vacuum Services Ltd | Manufacturing | 1996 |
| York Vale Fencing Limited | Construction | 2002 |
| York Vale Kitchens Ltd | Wholesale & retail | 2003 |
| York Van Centre Ltd | Wholesale & retail | 1999 |
| York Vape Ltd | Wholesale & retail | 2025 |
| York Vegan Food Ltd | Wholesale & retail | 2020 |
| York Vineyard | Administrative & support | 2008 |
| York Vodka Ltd | Wholesale & retail | 2022 |
| York Warehousing & Distribution Ltd | Administrative & support | 2000 |
| York Warehousing & Distribution Transport Ltd | Transport & logistics | 2020 |
| York Wetrooms Limited | Construction | 2014 |
| York Wheels Limited | Transport & logistics | 2002 |
| York Wholesale Meats Ltd | Wholesale & retail | 2017 |
| York Wifi Solutions Ltd | Information & communication | 2021 |
| York Windows & Garage Doors Limited | Construction | 2015 |
| York Windows Manufacturing Ltd | Manufacturing | 2024 |
| York Wines (Sheriff Hutton) Limited | Wholesale & retail | 2003 |
| York Wood Flooring Limited | Construction | 2020 |
| York-Cleaners Ltd | Administrative & support | 2022 |
| YORK3D Ltd | Professional & scientific | 2012 |
| YORK4WALLS Ltd | Manufacturing | 2019 |