| Shadowclub Creative Ltd | Information & communication | 2025 |
| Shady Adie Limited | Wholesale & retail | 2025 |
| Shahi RAJ Ltd | Hospitality | 2017 |
| Shaken & Co Events Ltd | Hospitality | 2020 |
| Shakers Bars Ltd | Hospitality | 2025 |
| Shakespeare Beds Limited | Manufacturing | 2005 |
| Sham Street Limited | Hospitality | 2026 |
| Sham the MAN Ltd | Transport & logistics | 2023 |
| Shambles Jewellers BRO Limited | Wholesale & retail | 2025 |
| Shambles Kitchen Catering Limited | Hospitality | 2015 |
| Shambles Kitchen Limited | Wholesale & retail | 2008 |
| Shambles OFF License Limited | Wholesale & retail | 2024 |
| Shan.Snty Ltd | Wholesale & retail | 2024 |
| Shanbj Education Ltd | Education | 2018 |
| Shane Goodwin Ltd. | Construction | 2007 |
| Shane Gray Racing Ltd | Arts & recreation | 2025 |
| Shane Sissons Loft Conversions Ltd | Construction | 2008 |
| Shankles & Co Butchery Ltd | Wholesale & retail | 2025 |
| Shannonigans Ltd | Administrative & support | 2011 |
| Share Sport Limited | Arts & recreation | 2009 |
| Shared Earth Liverpool Ltd | Wholesale & retail | 2012 |
| Shared Earth UK Limited | Wholesale & retail | 2010 |
| Shared Earth York Ltd | Wholesale & retail | 2013 |
| Shared Equity Limited | Professional & scientific | 2014 |
| Shared York CIC | Administrative & support | 2025 |
| Sharman Scientific Ltd | Professional & scientific | 2025 |
| Sharni F and C Ltd | Hospitality | 2026 |
| Sharp Financial Planning Ltd | Financial services | 2023 |
| Sharpen Corporate Finance Ltd | Financial services | 2024 |
| Sharps Agricultural Services Limited | Wholesale & retail | 2019 |
| Sharps World of Wood Limited | Wholesale & retail | 2005 |
| Sharptools Limited | Professional & scientific | 2025 |
| Shaun Batchelor Electrical Contractors Ltd. | Construction | 2002 |
| Shaun Buckle Decorators Ltd | Construction | 2003 |
| Shaun Palmer Scaffolding Hire & Sales Limited | Construction | 2019 |
| Shaun Rose Limited | Real estate | 2019 |
| Shaw & Riley Limited | Extraterritorial | 2018 |
| Shaw Developments (York) Ltd | Extraterritorial | 2010 |
| Shaw Technical Solutions Ltd | Information & communication | 2010 |
| Shaw's Reclaimed Roofing Ltd | Construction | 2020 |
| Shaw's Roofing Limited | Construction | 2022 |
| Shawwell Business Centre Ltd | Real estate | 2010 |
| Shdn Limited | Education | 2024 |
| SHE Loves/He Loves Ltd | Professional & scientific | 2018 |
| SHE Made IT Limited | Administrative & support | 2021 |
| Sheard Property Ltd | Real estate | 2019 |
| Shedden Farms Livestock Limited | Agriculture & fishing | 2024 |
| Sheep the Sheep Limited | Professional & scientific | 2011 |
| Shelftrak Ltd | Professional & scientific | 2025 |
| Shelley Antiques Ltd | Wholesale & retail | 2024 |
| Shelley House (York) RTM Company Limited | Households | 2012 |
| Shelly Developments Ltd | Real estate | 2024 |
| Shelved Limited | Manufacturing | 2020 |
| Shenfield Tandoori Limited | Hospitality | 2022 |
| Shephard Hill Civil Engineering Limited | Wholesale & retail | 1990 |
| Sheppee Holdings Ltd | Extraterritorial | 2008 |
| Sheppey Beach Villas Limited | Real estate | 2004 |
| Shepstone Homes Limited | Construction | 2016 |
| Sherbourne Properties (Warwick) Limited | Extraterritorial | 1964 |
| Sherburn Christmas Trees Limited | Agriculture & fishing | 2014 |
| Sherburn Gardens Residents Management Company Limited | Households | 2023 |
| Sherbutt Home Care Services Limited | Health & social care | 2010 |
| Sherbutt Residential Services Limited | Health & social care | 2005 |
| Sherdley Bathrooms & Interiors Ltd | Wholesale & retail | 2022 |
| Sherdley Bathrooms Ltd | Wholesale & retail | 2024 |
| Sherdley Builders Merchants Ltd | Wholesale & retail | 2024 |
| Sheriff Hutton Holdings Limited | Construction | 2011 |
| Sherlock Home Surveys Ltd | Households | 2023 |
| Sherwood Brothers Limited | Agriculture & fishing | 2016 |
| Sherwood Property Associates Ltd | Real estate | 2025 |
| SHI Shang York Limited | Hospitality | 2024 |
| SHI YI Ling Table Tennis Club Limited | Arts & recreation | 2007 |
| Shield Industrial Limited | Construction | 2016 |
| Shifta Bike Ltd | Information & communication | 2025 |
| Shilin House Ltd | Hospitality | 2022 |
| Shimmer & Shine, Cleaning Divine Ltd | Administrative & support | 2023 |
| Shimmin Property Limited | Real estate | 2024 |
| Shine Bright Property Ltd | Real estate | 2025 |
| Shine Mine Ltd | Administrative & support | 2025 |
| Shinom Ltd | Wholesale & retail | 2025 |
| Shipston Veterinary Centre Limited | Professional & scientific | 2004 |
| Shipton Lane Dairies Limited | Agriculture & fishing | 2021 |
| Shipton Road Ltd | Real estate | 2025 |
| Shire Aggregates Limited | Wholesale & retail | 2003 |
| Shire Holidays & Travel Limited | Information & communication | 1971 |
| Shire Oaks Developments Ltd | Real estate | 2024 |
| Shire Oaks Farms LLP | | 2022 |
| Shirewood (Beighton Road) Management Company Limited | Households | 2017 |
| Shish Happens Ltd | Hospitality | 2024 |
| Shoebox Storage Solutions Ltd | Transport & logistics | 2020 |
| Shokunin Yorkht Ltd | Hospitality | 2024 |
| Shop Sustain Limited | Wholesale & retail | 2025 |
| Shopmobility York | Other services | 1998 |
| Shorrocks Car Sales Limited | Wholesale & retail | 2011 |
| Short Term Lettings (Yorks) Limited | Real estate | 2022 |
| Shot House Ltd | Professional & scientific | 2024 |
| Shouksmith Developments Limited | Construction | 1997 |
| Shouksmiths Limited | Wholesale & retail | 1976 |
| Shoulder and Elbow Surgery Limited | Health & social care | 2017 |
| Shram Ltd | Information & communication | 2023 |