| NEP Comms Ltd | Information & communication | 2026 |
| Nest Interior Design Ltd | Professional & scientific | 2022 |
| Netherby Property Limited | Real estate | 2017 |
| Networking Durham and Teesside Ltd | Information & communication | 2012 |
| Networking North Yorkshire Limited | Information & communication | 2021 |
| New Earth Therapeutic Provision CIC | Education | 2026 |
| New ERA Foods Ltd | Professional & scientific | 2022 |
| New Vintage Properties Ltd | Real estate | 2024 |
| Nexora Group Solutions Limited | Professional & scientific | 2025 |
| Nextgen Zero Limited | Professional & scientific | 2025 |
| NG Clancy Logistics Ltd | Transport & logistics | 2025 |
| Nimbus Properties (NE) Ltd | Real estate | 2020 |
| NIP Management Ltd | Professional & scientific | 2025 |
| Nishara Food and Wine Ltd | Wholesale & retail | 2023 |
| NJ PMC Ltd | Professional & scientific | 2018 |
| NM Project Planning Services Limited | Administrative & support | 2015 |
| NM Shopfitting and Joinery Limited | Construction | 2008 |
| NO Mistakes Publishing Limited | Arts & recreation | 2021 |
| Noir Interior Design Limited | Professional & scientific | 2024 |
| Norman Rogers Limited | Manufacturing | 2024 |
| Northallerton Concrete Products Limited | Manufacturing | 2020 |
| Northern Bay Leisure Limited | Hospitality | 2012 |
| Northern Tank Services Ltd | Wholesale & retail | 2011 |
| Novella Aesthetics Yarm Ltd | Other services | 2025 |
| NPS Media Limited | Professional & scientific | 2004 |
| O&M Consultants Ltd | Professional & scientific | 2016 |
| O'Hara Offshore Ltd. | Administrative & support | 2017 |
| Oak LEA Consulting Services Ltd | Professional & scientific | 2023 |
| Oakstone Properties Limited | Real estate | 2011 |
| Offshore Wind Quality Consultants Ltd | Professional & scientific | 2011 |
| Oilserv (UK) Ltd. | Mining & quarrying | 2009 |
| Old Mill Apartments Limited | Hospitality | 2007 |
| Omnitherm Ltd | Construction | 2024 |
| Or-And-A Ltd. | Professional & scientific | 2024 |
| Orchard Creations Ltd | Manufacturing | 2022 |
| Organic Coffee Shops Ltd | Hospitality | 2025 |
| Orient Electrical Contractors Ltd | Construction | 2022 |
| Ornskold Ltd | Financial services | 2016 |
| Orpex Ltd | Wholesale & retail | 2025 |
| Orthocare Plus Ltd | Health & social care | 2024 |
| OS Psychology Ltd | Health & social care | 2025 |
| P & P Site Work Limited | Professional & scientific | 1986 |
| P J D Rigging & Safety Services Limited | Construction | 2013 |
| P J Hudson Ltd | Other services | 2021 |
| P1X Ltd | Construction | 2025 |
| Palmer Windscreens Limited | Wholesale & retail | 2019 |
| Panovista Limited | Administrative & support | 2025 |
| Pantheon Group Ltd | Professional & scientific | 2021 |
| Patrick Medical Ltd | Health & social care | 2019 |
| Paws at Peace Ltd. | Professional & scientific | 2024 |
| Peapa Ltd | Education | 2025 |
| Pearlrose Investments Limited | Financial services | 2026 |
| Pearson & Black Limited | Wholesale & retail | 1997 |
| Pentek Systems Limited | Information & communication | 2005 |
| Pepas White Ltd | Manufacturing | 2025 |
| PFI Limited | Real estate | 2022 |
| Pick Consulting Limited | Information & communication | 2024 |
| Picktree Motors Ltd | Wholesale & retail | 2003 |
| Picton Trading Ltd | Hospitality | 2019 |
| Piel Beauty Ltd | Other services | 2024 |
| PIL Sung Martial Arts LLP | | 2011 |
| Pitchpod Sports Ltd | Wholesale & retail | 2026 |
| Pizza & Co Express Yarm Limited | Hospitality | 2018 |
| PJW Energy Limited | Professional & scientific | 2023 |
| PKA Property Investments Ltd | Real estate | 2023 |
| Pods and Peas Ltd | Administrative & support | 2012 |
| Port Clarence Land Limited | Real estate | 2012 |
| Portobello Global Ltd | Wholesale & retail | 2020 |
| Power Grid Services Ltd | Energy | 2025 |
| Pravesh Properties Limited | Real estate | 2026 |
| Preference Limited | Professional & scientific | 2019 |
| Preston's Transport Limited | Transport & logistics | 1962 |
| Priestley-Price Properties Ltd | Real estate | 2021 |
| Prime Dealings UK Limited | Wholesale & retail | 2025 |
| Probate Dispute Resolution Limited | Professional & scientific | 2016 |
| Process Fire Engineering Ltd | Extraterritorial | 2026 |
| Product Thought Limited | Professional & scientific | 2025 |
| Progett Engineering Ltd | Professional & scientific | 2022 |
| Project Controls Pros Limited | Professional & scientific | 2023 |
| Protilit Ltd | Information & communication | 2007 |
| PSB Associates (Consulting) Ltd | Professional & scientific | 2013 |
| PT Medical Ltd | Health & social care | 2022 |
| PTW Safety Control Ltd | Professional & scientific | 2018 |
| Quality Clinical Solutions Ltd | Health & social care | 2016 |
| Quantic Airlines Limited | Transport & logistics | 2015 |
| R Berryman Ltd | Information & communication | 2025 |
| R J Hodgson Ltd | Professional & scientific | 2019 |
| R4 Window Cleaning Services Ltd | Administrative & support | 2025 |
| RAM Associates Ltd | Health & social care | 2024 |
| Rayner Future Investments Ltd | Real estate | 2025 |
| Rcderm Limited | Health & social care | 2024 |
| Rcjm Ltd | Health & social care | 2015 |
| Rcjm Property Ltd | Real estate | 2024 |
| REE Investments Ltd | Real estate | 2024 |
| Reecewood Ltd. | Mining & quarrying | 2009 |
| Reflect Yarm Ltd | Health & social care | 2017 |
| Regarder Ltd | Wholesale & retail | 2019 |
| Replanted Limited | Professional & scientific | 2007 |
| Resolution North East Limited | Education | 2015 |
| Revelry Spirits Ltd | Manufacturing | 2018 |