| ROT8 Ltd | Professional & scientific | 2018 |
| SANTORINIEST2023 Limited | Hospitality | 2023 |
| Schmitz Cargobull (U.K.) Limited | Manufacturing | 1991 |
| Scott Precision Wire Ltd | Manufacturing | 1923 |
| Simply Cargo Wholesale Limited | Transport & logistics | 2022 |
| Sky Stay Ltd | Real estate | 2022 |
| Smartwin Co., Ltd | Transport & logistics | 2023 |
| Solace Funeral Care Limited | Other services | 2021 |
| Soni Sebastian Ltd | Transport & logistics | 2025 |
| South Manchester Gate & Barrier Limited | Construction | 1999 |
| Stansfield Street 1-3 RTM Company Ltd | Real estate | 2016 |
| Stansfield Street 5 RTM Company Ltd | Households | 2016 |
| Status Projects Limited | Construction | 2016 |
| Symphony Textiles UK Ltd | Wholesale & retail | 2018 |
| T Trotter Limited | Other services | 2010 |
| Telair (Warrington) Limited | Manufacturing | 2005 |
| Thacker's Pharmacy Limited | Wholesale & retail | 2002 |
| THE Battered COD Limited | Hospitality | 2014 |
| THE Howells Group PLC | Financial services | 1990 |
| THE Pinstripe Club Ltd | Professional & scientific | 2011 |
| Thorpe Close RTM Company Limited | Households | 2020 |
| Timpson Franchises Limited | Extraterritorial | 1964 |
| Timpson Retail Limited | Extraterritorial | 1938 |
| Timpson Services Limited | Extraterritorial | 1916 |
| Timpson Shoes Limited | Extraterritorial | 1938 |
| Timpson SOL Limited | Real estate | 2008 |
| TLG Linen Services Ltd | Other services | 2007 |
| TML Mechanical Services Limited | Manufacturing | 2015 |
| Total Business Solutions MCR Limited | Administrative & support | 2019 |
| Trilogy Logistics Limited | Transport & logistics | 2025 |
| Vaughan-Mason Consulting Limited | Other services | 2014 |
| Vbpc IT Solutions Limited | Information & communication | 2018 |
| WA Initiatives Limited | Wholesale & retail | 2024 |
| William Pinder & Sons Limited | Manufacturing | 1951 |
| Wythenshawe Community Initiative Ltd | Education | 2005 |
| Wythenshawe Forum Trust Limited | Education | 2002 |
| Wythenshawe Oasis | Other services | 2002 |
| Wythenshawe Town Women FC Ltd | Arts & recreation | 2026 |
| YMJ Consultancy Ltd | Professional & scientific | 2014 |
| Zocustek Electronic Ltd | Other services | 2022 |