| Somera Management Ltd | Real estate | 2024 |
| Somnogen Ltd | Health & social care | 2025 |
| Sonbeam Autos Limited | Wholesale & retail | 2025 |
| Soniko Ltd | Manufacturing | 2022 |
| Sonskey Limited | Real estate | 2001 |
| Sontley Farms Limited | Agriculture & fishing | 2002 |
| Sontley Properties Limited | Real estate | 2013 |
| Sora Taste Limited | Hospitality | 2021 |
| SOS Aggregates Ltd | Construction | 2022 |
| SOS Plant Hire Ltd | Administrative & support | 2017 |
| SOS Plant Sales Ltd | Wholesale & retail | 2023 |
| Sosduk Ltd | Arts & recreation | 2021 |
| South Wales Trading Ltd | Other services | 2017 |
| South Yorkshire Debt I LP | | 2025 |
| Southcroft Healthcare Ltd | Health & social care | 2016 |
| Sovereign Trader Holdings Ltd | Information & communication | 2025 |
| SP Autocare Services Ltd | Wholesale & retail | 2023 |
| SP Edwards Logistics Ltd | Transport & logistics | 2016 |
| Space FOX Media Ltd | Administrative & support | 2018 |
| Spaces by Hexagon Ltd | Real estate | 2019 |
| Spacetime VA Ltd | Administrative & support | 2023 |
| Spark Nova Ltd | Wholesale & retail | 2025 |
| Sparkles Cleaning Services NW Limited | Administrative & support | 2026 |
| Spartan Training Centre Ltd | Arts & recreation | 2025 |
| SPD Advisory Limited | Professional & scientific | 2025 |
| SPE Services Limited | Professional & scientific | 2015 |
| Speakman & Parmar Limited | Wholesale & retail | 2018 |
| Speaks Design Services Ltd | Professional & scientific | 2024 |
| Spec Line Designs Ltd | Construction | 2024 |
| Special Strategy Consulting Limited | Professional & scientific | 2022 |
| Specialist Chauffeur Services Limited | Transport & logistics | 2018 |
| Specialist Construction Fabrications Limited | Manufacturing | 2025 |
| Specialist Tree Care Limited | Agriculture & fishing | 2002 |
| Spectrum Motor Centre Limited | Wholesale & retail | 2005 |
| Speedie Cars Ltd | Transport & logistics | 2008 |
| Speedway Coachworks Ltd | Wholesale & retail | 2020 |
| SPI Research Limited | Other services | 2015 |
| Spice Lounge Wrexham Ltd | Hospitality | 2021 |
| Spidey Properties Ltd | Information & communication | 2017 |
| Splash Community Trust Ymddiriedolaeth Gymunedol Sblash | Arts & recreation | 2014 |
| Sport Casual Limited | Wholesale & retail | 2015 |
| Sprake Energy Ltd | Professional & scientific | 2024 |
| Spudbaddie Ltd | Hospitality | 2025 |
| SQF Holdings Ltd | Professional & scientific | 2022 |
| Squiggle Enterprise Ltd | Construction | 2022 |
| SR Research Associates Limited | Professional & scientific | 2016 |
| Sreeniti Properties Ltd | Real estate | 2015 |
| SRM Haulage Services Ltd | Transport & logistics | 2018 |
| SRS Event Medical Ltd. | Health & social care | 2024 |
| SS Developments Wrexham Ltd | Real estate | 2014 |
| SS Rentals Ltd | Real estate | 2017 |
| SSI Global Ltd | Wholesale & retail | 2017 |
| Ssse Properties Limited | Real estate | 2021 |
| ST Bathrooms and Heating Limited | Construction | 2026 |
| ST. Winefride's Well Shrine Company Ltd | Wholesale & retail | 2017 |
| Stag Marketing Group Ltd | Professional & scientific | 2025 |
| Stamford Way Fisheries and Camping Limited | Arts & recreation | 2012 |
| Stanbeth Properties Ltd | Construction | 2021 |
| Standby Sourcing Limited | Real estate | 2025 |
| Stantech Electrical Services Limited | Construction | 1992 |
| Stantech Limited | Professional & scientific | 2021 |
| Stapley Haulage Limited | Transport & logistics | 2025 |
| Star Fish Chirk Ltd | Hospitality | 2023 |
| Star Pizza Chirk Ltd | Hospitality | 2021 |
| Star Turkish Ltd | Other services | 2021 |
| Stars Hand Car Wash Ltd | Other services | 2023 |
| Statham & Co (Moving & Storage) Limited | Transport & logistics | 2022 |
| Station Cars (Wrexham) Limited | Administrative & support | 2017 |
| Station Salon Limited | Real estate | 2017 |
| Stationhouse Creative Design Limited | Manufacturing | 1986 |
| Stax Archaeology Limited | Professional & scientific | 2025 |
| Stay Keen Limited | Health & social care | 2025 |
| Steffs Plaice Ltd | Hospitality | 2022 |
| Step IT Solutions Limited | Information & communication | 2002 |
| Stepping Stone Path Limited | Health & social care | 2024 |
| Stethoscope Medical CYF | Health & social care | 2020 |
| Steve Broad Ltd | Construction | 2007 |
| Steve K Limited | Professional & scientific | 1998 |
| Stewart Rawson Electrical Limited | Construction | 2015 |
| Stitch Global Ltd | Professional & scientific | 2023 |
| Stiwdio Olivet CIC | Education | 2024 |
| Stiwt Arts Trust Limited | Arts & recreation | 1997 |
| Stoked DEE Valley Sauna Ltd | Health & social care | 2024 |
| Stollmoor Limited | | 1973 |
| Stone Circle Mead Company Limited | Manufacturing | 2018 |
| Stoneleigh Management Company Limited | Households | 1999 |
| Stori Brymbo Ltd | Arts & recreation | 2025 |
| Storypie Limited | Extraterritorial | 2015 |
| Stot Services Ltd | Health & social care | 2022 |
| Stove Installer Ltd | Construction | 2022 |
| Strategus (UK) Ltd | Professional & scientific | 2013 |
| Striped Care Ltd | Health & social care | 2025 |
| Stuart Hughes Haulage Ltd | Transport & logistics | 2003 |
| Student World Online Limited | Administrative & support | 2012 |
| Studio 1018 Ltd | Wholesale & retail | 2025 |
| Studio Connections Limited | Manufacturing | 2004 |
| Stumat Properties Limited | Real estate | 2016 |
| Stunex Limited | Hospitality | 2018 |
| Suave Products Limited | Other services | 2018 |
| Subash & Sons UK Ltd | Wholesale & retail | 2024 |