| Eric's BOY Limited | Construction | 2013 |
| Eriksen Limited | Professional & scientific | 2006 |
| Erlas Victorian Walled Garden | Health & social care | 2008 |
| Ernst Nutrition Limited | Health & social care | 2011 |
| ERS Suspension Ltd | Wholesale & retail | 2023 |
| Ersb Properties Holdings Limited | Real estate | 2019 |
| Ertex UK Limited | Wholesale & retail | 2021 |
| Ervyk (UK) Limited | Construction | 1991 |
| Escape Code Games Ltd | Information & communication | 2024 |
| Escape Ordinary Group Ltd | Financial services | 2021 |
| Eseda Enterprise Ltd | Hospitality | 2022 |
| ESI Technology Limited | Manufacturing | 1990 |
| Eskdalemuir Wind Farm Limited | Energy | 2007 |
| ESL (Architectural Systems) Limited | Construction | 2009 |
| ESL Property Management Limited | Construction | 2013 |
| Essbea Limited | Wholesale & retail | 2017 |
| Essen Cakes Ltd. | Wholesale & retail | 2025 |
| Essentials MAG Limited | Information & communication | 2014 |
| Esteban U.K. Limited | Manufacturing | 1998 |
| Estma Investors Limited | Real estate | 2022 |
| Eternal Media Limited | Information & communication | 2019 |
| Etherington Imaging Limited | Health & social care | 2011 |
| Ethos Public Relations Limited | Professional & scientific | 2006 |
| Etiquette Labelling Systems Limited | Manufacturing | 2005 |
| Etiquette Labels Limited | Manufacturing | 1991 |
| Etiquette Packaging Systems Ltd. | Manufacturing | 1998 |
| Euclid Management Limited | Professional & scientific | 2016 |
| Euro Resources Ltd | Administrative & support | 2005 |
| Euro Shop Wrexham Ltd | Wholesale & retail | 2024 |
| Eurocom Marketing Limited | Administrative & support | 2003 |
| Eurolite Consultancy Limited | Professional & scientific | 2011 |
| European Scientific Resources Ltd | Professional & scientific | 2018 |
| Evans Lamsley Limited | Professional & scientific | 2018 |
| Evapor Ltd | Wholesale & retail | 2012 |
| Events Medical Team - Saltney Limited | Health & social care | 2023 |
| Ever Grab & Aggregates Ltd | Water & waste | 2024 |
| Everbright Hotel Ltd | Hospitality | 2014 |
| Evergreen Fresh Foods Ltd | Wholesale & retail | 2014 |
| Evergreen International Ltd | Transport & logistics | 2023 |
| Everhealth Ltd | Health & social care | 2025 |
| Everheart Books Ltd | Wholesale & retail | 2025 |
| Evershift Ltd | Water & waste | 2025 |
| Everything With Electrics Limited | Manufacturing | 2003 |
| EVF Technical Limited | Other services | 2023 |
| Evie Bell Limited | Wholesale & retail | 2022 |
| Evied Construction Limited | Construction | 2007 |
| Evil OWL Studios Ltd. | Information & communication | 2019 |
| Evolution ABC CIC | Arts & recreation | 2025 |
| Evolved MEN Coaching Ltd | Health & social care | 2025 |
| Excel Signs Limited | Administrative & support | 2006 |
| Excellence Healthcare Recruitment Limited | Health & social care | 2018 |
| Exclusively Equestrian Ltd | Wholesale & retail | 2018 |
| Exhale Wellness Limited | Real estate | 2026 |
| Experience Elite Limited | Administrative & support | 2010 |
| Exponencia Limited | Professional & scientific | 2023 |
| Express Donuts Limited | Hospitality | 2022 |
| Extra Procurement Limited | Administrative & support | 2016 |
| Eyecare 4 U Ltd | Wholesale & retail | 2010 |
| EZ Publishing Limited | Information & communication | 2020 |
| Eztuning Ltd | Manufacturing | 2024 |
| F & O Homes Ltd | Construction | 2016 |
| F & O Wealth Management Limited | Financial services | 2024 |
| F Bender Limited | Manufacturing | 1984 |
| F Jones (Colwyn Bay) Limited | Wholesale & retail | 1993 |
| F Jones Limited | Wholesale & retail | 2022 |
| F. M. Security (NW) Limited | Construction | 2008 |
| F1RSTPHASE Ltd | Professional & scientific | 2025 |
| Fabwell Engineering Services Limited | Manufacturing | 2000 |
| Facade Surveying Services Ltd | Professional & scientific | 2019 |
| Fade Zone Barber LL11 Ltd | Other services | 2026 |
| Fade Zone Barber Wrexham Ltd | Other services | 2024 |
| Fades Barber Shop Ltd | Other services | 2024 |
| Fair Event Management Ltd. | Other services | 2020 |
| Fairfield Meat Company Limited | Wholesale & retail | 2019 |
| Fairoak Properties (North Wales) Ltd | Real estate | 2025 |
| Fairway Golf UK Ltd | Wholesale & retail | 2018 |
| Faith Kansara Medical Ltd | Health & social care | 2020 |
| Falcon EYE Services Ltd | Administrative & support | 2025 |
| Fallon Fire and Security Limited | Administrative & support | 2022 |
| Family Rhosddu Market Limited | Wholesale & retail | 2025 |
| Fantazia Fireworks Ltd | Arts & recreation | 2022 |
| Fantazia Imports Ltd | Administrative & support | 2016 |
| FAR Recruitment Ltd | Administrative & support | 2026 |
| Faraway Follies Limited | Hospitality | 2024 |
| Farm Renewable Environmental Energy Limited | Administrative & support | 2007 |
| Farmers Fresh (Wales) Limited | Wholesale & retail | 2002 |
| Farmworld Limited | Extraterritorial | 2014 |
| Farndon Heating Solutions Limited | Manufacturing | 2016 |
| FAT FOX Coffee Ltd | Hospitality | 2023 |
| Fatcats Cattery Limited | Professional & scientific | 2004 |
| Father's Place | Other services | 2012 |
| Fauxdegla Shooting Ground Limited | Arts & recreation | 2010 |
| FC Team Wear Limited | Wholesale & retail | 2012 |
| Fearnall Properties Limited | Real estate | 2024 |
| Feds Sliding Systems Limited | Manufacturing | 2025 |
| Feel Movement Limited | Wholesale & retail | 2025 |
| Felton Freight Limited | Transport & logistics | 2024 |
| Ferdi's Ltd | Wholesale & retail | 2026 |
| Ferndale Foods Limited | Manufacturing | 1992 |
| Fernleas Holdings Limited | Real estate | 2025 |