| Smokiburger Ltd | Hospitality | 2022 |
| SMR Roofing (Worthing) Ltd | Construction | 2026 |
| SMS Rigging Limited | Construction | 2025 |
| Smyth Mechanical Ltd | Construction | 2025 |
| Snake People Media Ltd | Information & communication | 2016 |
| Snap Inclusive Consultancy Ltd | Education | 2026 |
| Snez Limited | Real estate | 2023 |
| Sniper Business Developments Limited | Administrative & support | 2003 |
| Snlf Media Ltd | Professional & scientific | 2025 |
| Snookies Limited | Hospitality | 2012 |
| Snowdale Limited | Real estate | 2010 |
| Soaps of Provence Limited | Wholesale & retail | 2008 |
| Soar Design & Construction Co. Ltd | Construction | 2021 |
| Social Attraction Limited | Information & communication | 2014 |
| Social Glow Ltd | Professional & scientific | 2021 |
| Social Saviour Ltd | Professional & scientific | 2023 |
| Social Seahorse Ltd | Professional & scientific | 2020 |
| Social Union Limited | Information & communication | 2019 |
| Sodium Software Ltd | Information & communication | 2025 |
| Softly Films Ltd | Information & communication | 2022 |
| Soil Rebels Ltd | Wholesale & retail | 2021 |
| Soki Fragrances Limited | Manufacturing | 2022 |
| Sokrat Limited | Professional & scientific | 2024 |
| Solace Movie Ltd | Information & communication | 2025 |
| Solana Advisory Limited | Wholesale & retail | 2026 |
| Solar Saints Ltd | Construction | 2026 |
| Solaris UK Holdings Limited | Financial services | 2023 |
| Solidea Investments Limited | Real estate | 2020 |
| Solitaire JV LLP | | 2021 |
| Solnx Group Ltd | Wholesale & retail | 2026 |
| Soluna Luxe Property Limited | Real estate | 2026 |
| Solutions AV Holdings Limited | Financial services | 2014 |
| Solutions AV Limited | Financial services | 2023 |
| Somathenics Ltd | Arts & recreation | 2026 |
| Somerhill Court Hove Limited | Real estate | 1996 |
| Somers Financial Limited | Financial services | 2011 |
| Somersets Lake Ltd | Agriculture & fishing | 2013 |
| Somnowell Marketing Ltd | Other services | 2015 |
| Sompting Stables Ltd | Agriculture & fishing | 2022 |
| Sompting Trade Centre Ltd | Wholesale & retail | 2017 |
| Song of Sounds Limited | Education | 2014 |
| Sonia Mooney Signature Solutions Ltd | Administrative & support | 2021 |
| Sophella Investments Limited | Real estate | 2023 |
| Sophella Properties Limited | Real estate | 2023 |
| Sopoco Limited | Construction | 2024 |
| Sorcha Bridge Photography Ltd | Wholesale & retail | 2025 |
| Soteria Guarding Ltd | Administrative & support | 2025 |
| Soul Bowl Nutrition Ltd | Hospitality | 2023 |
| Soul Place Limited | Other services | 2014 |
| Sound Landscaping Limited | Construction | 2012 |
| Sound Solutions (Holdings) Limited | Professional & scientific | 2017 |
| Sound Solutions Limited | Construction | 1996 |
| Sound Solutions Property Limited | Real estate | 2021 |
| Soundbass Limited | Wholesale & retail | 2016 |
| Soundcheck Rock and Metal Bars Ltd | Hospitality | 2024 |
| Soundcircus Limited | Arts & recreation | 1999 |
| Sounds Sweet'Man Ltd | Information & communication | 2014 |
| Soundsdecent Limited | Administrative & support | 2026 |
| Soup Training Limited | Other services | 2019 |
| Sourdough Limited | Hospitality | 2021 |
| South & Martin Roofing Ltd | Construction | 2007 |
| South Coast Auto Body Repairs Limited | Wholesale & retail | 2016 |
| South Coast Coffee Co.Limited | Wholesale & retail | 1964 |
| South Coast Competitions Ltd | Other services | 2023 |
| South Coast Contracting Services Limited | Information & communication | 2016 |
| South Coast Digger Hire Ltd | Administrative & support | 2021 |
| South Coast Elite Basketball Ltd | Arts & recreation | 2015 |
| South Coast Exteriors Limited | Construction | 2005 |
| South Coast Independent Paediatric Staffing Ltd | Administrative & support | 2018 |
| South Coast Indian Takeaway Limited | Hospitality | 2016 |
| South Coast Macarons Ltd | Manufacturing | 2015 |
| South Coast Nursing Homes Limited | Health & social care | 1977 |
| South Coast Orthopaedics Ltd | Health & social care | 2010 |
| South Coast Padel Ltd | Arts & recreation | 2026 |
| South Coast Skate Club C.I.C. | Arts & recreation | 2019 |
| South Coast Trainingt/A Richard John Academy Limited | Education | 2015 |
| South Corner Property Limited | Financial services | 2011 |
| South Downs Bikes Limited | Wholesale & retail | 2004 |
| South Downs Digital Ltd | Information & communication | 2025 |
| South Downs Education Trust | Education | 2012 |
| South Downs Home Physio Limited | Health & social care | 2021 |
| South Downs Leisure | Arts & recreation | 2014 |
| South Downs Leisure Enterprises Limited | Other services | 2014 |
| South Downs Property Management Ltd | Real estate | 2021 |
| South East Leasehold Ltd | Professional & scientific | 2026 |
| South East Signs Ltd | Construction | 2019 |
| South East Valuers Ltd | Real estate | 2021 |
| South Farm Road Limited | Real estate | 2013 |
| South Hants Heating and Plumbing Limited | Other services | 2005 |
| South West Caravans Ltd | Wholesale & retail | 2017 |
| Southcoast Cheer Limited | Education | 2025 |
| Southcoast Pickleball Club Ltd | Arts & recreation | 2025 |
| Southdown Brickwork Limited | Construction | 2014 |
| Southdown GUN Club Limited | Arts & recreation | 2010 |
| Southdown GUN Room & Shooting Supplies Limited | Wholesale & retail | 2017 |
| Southdown Historic Vehicles Limited | Transport & logistics | 2002 |
| Southdown Media Ltd | Information & communication | 2019 |
| Southdown Medical Writing Limited | Administrative & support | 2012 |
| Southdowns Pet Ambulance Ltd | Other services | 2022 |
| Southdowns Pet Supplies Ltd | Wholesale & retail | 2024 |