| Seawen Properties Ltd | Real estate | 2026 |
| Secure Control Systems Ltd | Professional & scientific | 2019 |
| Seffy Corp. UK Ltd | Wholesale & retail | 2021 |
| Selectify Ltd | Wholesale & retail | 2025 |
| Sellar Construction Limited | Construction | 2024 |
| Selona Ltd | Information & communication | 2023 |
| Semfex Properties Limited | Real estate | 2024 |
| Semfex Solutions Limited | Information & communication | 2010 |
| Sempra Design Limited | Administrative & support | 2016 |
| SEN Venture Ltd | Financial services | 2021 |
| Senn House Ltd | Real estate | 2020 |
| Sentrymatic Ltd | Manufacturing | 2017 |
| Serandives Consulting Ltd | Information & communication | 2009 |
| Serban Bros Ltd | Construction | 2005 |
| SES 1 Limited | Real estate | 2015 |
| SES Lifestyle Homes Limited | Real estate | 2023 |
| SES Lifestyle Projects Limited | Real estate | 2023 |
| SES Lilium Limited | Real estate | 2020 |
| Sevgas Limited | Construction | 2022 |
| SG Construction Solutions Ltd | Construction | 2024 |
| SG Holdings (2025) Ltd | Financial services | 2025 |
| SH. CHO Ltd | Wholesale & retail | 2021 |
| Shade Scaffolding Limited | Administrative & support | 2016 |
| Shahzad Investments London Limited | Real estate | 2025 |
| Shanel Electric Limited | Construction | 2015 |
| Sharan Auto Tech Ltd | Wholesale & retail | 2022 |
| Sharia Solutions & Compliance Ltd | Professional & scientific | 2008 |
| Sharpwaves Limited | Other services | 2014 |
| Shas Katungal Ltd | Wholesale & retail | 2025 |
| Shed Apartments Ltd | Households | 2023 |
| Sheephouse Associates Ltd | Professional & scientific | 2019 |
| Sherub Property Management Limited | Real estate | 2013 |
| Sherwoods Scaffolding Ltd | Construction | 2018 |
| Shine and Go CIC | Public administration | 2025 |
| Shinemobile Car Cleaning Ltd | Administrative & support | 2025 |
| Shiri Technologies Limited | Information & communication | 2017 |
| Shiv Engineering Services Limited | Professional & scientific | 2012 |
| Short Bark & Sides Limited | Other services | 2016 |
| Sicilian Brothers Ltd | Wholesale & retail | 2025 |
| Sigita Dauksaite Ltd | Manufacturing | 2022 |
| Signworks (UK) Limited | Professional & scientific | 2008 |
| Silver Birch Kitchen Designs Ltd | Wholesale & retail | 2020 |
| Silver Oak Developments Ltd | Real estate | 2006 |
| SIM & Huang Consulting Limited | Information & communication | 2009 |
| Simon Donohue Ltd | Arts & recreation | 2024 |
| Simply 07 Limited | Administrative & support | 2017 |
| Sizzle Greens Ltd | Hospitality | 2025 |
| SJ Burch Limited | Information & communication | 2016 |
| SJ Premier Property Management Ltd | Construction | 2025 |
| SJM Print Finishing Limited | Manufacturing | 2007 |
| SJS Health Consulting Ltd | Professional & scientific | 2023 |
| SKB Global Consulting Ltd | Information & communication | 2007 |
| Skky Consulting Limited | Information & communication | 2023 |
| Skma Digital Limited | Education | 2023 |
| Skma Limited | Education | 2007 |
| Sky Garden Property Investments Ltd | Real estate | 2020 |
| Sky Media Services Limited | Information & communication | 2023 |
| Sky Scaffolding Ltd | Construction | 2020 |
| SL Auto Wash Ltd | Administrative & support | 2025 |
| Slmdent Ltd | Education | 2023 |
| SLS Group Holding Limited | Financial services | 2026 |
| Smart Angel Capital Limited | Administrative & support | 2021 |
| Smart Outsourcing and Consultancy Limited | Information & communication | 2013 |
| Smart Residential Investments Ltd | Construction | 2019 |
| Smart Venture Capital Limited | Administrative & support | 2020 |
| Smartnest Design and Lighting Ltd | Wholesale & retail | 2025 |
| Smartvan Services Ltd | Transport & logistics | 2025 |
| Smashing Groundwork's Ltd | Construction | 2022 |
| Smile & Style Ltd | Health & social care | 2022 |
| SMP Consulting Ltd | Information & communication | 2019 |
| SN Associates Accountants Ltd | Professional & scientific | 2016 |
| SN Beauty Aesthetic Clinic Ltd | Health & social care | 2021 |
| Snappystrat Ltd | Professional & scientific | 2026 |
| Snasir Limited | Information & communication | 2018 |
| SND Partnering Ltd | Professional & scientific | 2021 |
| Snew Ltd | Real estate | 2015 |
| SNS C-Retail Ltd | Extraterritorial | 2015 |
| SO FAR SO Good Search Ltd | Administrative & support | 2024 |
| Sobha Hareesh Ltd | Health & social care | 2015 |
| Softcompy Ltd | Information & communication | 2025 |
| Sohi Enterprise Ltd | Real estate | 2016 |
| Soho London Ltd | Wholesale & retail | 2020 |
| Solen-Uk Limited | Manufacturing | 2025 |
| Solo Cars Ltd | Administrative & support | 2024 |
| Sonad Limited | Professional & scientific | 2020 |
| Soni Design Studio Limited | Construction | 2009 |
| Sonic Muse Limited | Information & communication | 2025 |
| Sooah Ltd | Other services | 2007 |
| Sophia A91 Ltd | Wholesale & retail | 2026 |
| SOS! Special Educational Needs | Education | 2013 |
| Sotto LE Stelle Ltd | Wholesale & retail | 2024 |
| Southern PAT Testing Ltd | Professional & scientific | 2021 |
| Southfields Solicitors Ltd | Professional & scientific | 2011 |
| Southwest Cars Limited | Transport & logistics | 2007 |
| Spanovic Cars Ltd | Wholesale & retail | 2023 |
| Spectra Property Management Limited | Real estate | 2018 |
| Spice Hub Caterers Ltd | Wholesale & retail | 2022 |
| Spirit of Beauty Limited | Extraterritorial | 1998 |
| SPM GAS & Heating Ltd | Wholesale & retail | 2026 |
| Sport Matcher Ltd | Information & communication | 2026 |