| Rise Topco Limited | Administrative & support | 2023 |
| Rocarc Ltd | Professional & scientific | 2024 |
| Rogue Interrobang Limited | Professional & scientific | 2018 |
| Rookie Equestrian Limited | Agriculture & fishing | 2018 |
| Rsae Limited | Professional & scientific | 2023 |
| Ruminari Group Ltd | Professional & scientific | 2025 |
| Rushbrook Operations Limited | Health & social care | 2020 |
| Salty Polo Ltd | Arts & recreation | 2023 |
| Savvymove Limited | Extraterritorial | 2024 |
| SC Lighting Ltd | Professional & scientific | 2021 |
| Sea Breeze Holidays Limited | Real estate | 2016 |
| Secure BIM Ltd | Information & communication | 2020 |
| Sedition Limited | Administrative & support | 2009 |
| Segavas Ltd | Professional & scientific | 2011 |
| Selecto-Part UK Limited | Manufacturing | 1998 |
| September Properties (Regional) Limited | Construction | 2016 |
| September(Wgc) Limited | Real estate | 2018 |
| SG Nexus Limited | Financial services | 2019 |
| Short LET Space Homes Ltd | Hospitality | 2014 |
| Short LET Space Ltd | Real estate | 2008 |
| Silverstone Race Technologies Ltd | Administrative & support | 2025 |
| Simfinity Labs Ltd | Professional & scientific | 2025 |
| Skinner Hospitality Ltd | Hospitality | 2024 |
| Slush Brothers Limited | Hospitality | 2019 |
| Smart Consultancy Solutions Inc Ltd | Professional & scientific | 2024 |
| Snell Holdings Limited | Professional & scientific | 1989 |
| Solar Fresh Limited | Wholesale & retail | 2017 |
| Soldiers of Oxfordshire Trading Limited | Arts & recreation | 2010 |
| Sophia Oxford UK Limited | Health & social care | 2018 |
| Sophie Olivia Floral Design Ltd | Wholesale & retail | 2021 |
| Sopilnik Construction Limited | Construction | 2024 |
| Sparkdev Limited | Information & communication | 2020 |
| Special Dent Service Limited | Wholesale & retail | 2022 |
| Speedsource Limited | Transport & logistics | 2008 |
| Spires Studio Ltd | Information & communication | 2016 |
| Sprink Ltd | Information & communication | 2019 |
| Stella Mannering Limited | Professional & scientific | 1990 |
| Street Research Consulting Ltd | Professional & scientific | 2025 |
| Strive High Performance Ltd | Arts & recreation | 2021 |
| Studio 8 Ltd | Professional & scientific | 2003 |
| Studio Future Ltd | Information & communication | 2011 |
| Sula Clinic Ltd | Health & social care | 2024 |
| SUMM8 Ltd | Information & communication | 2017 |
| TDR Consultancy Limited | Financial services | 2005 |
| Terravestin Properties Limited | Real estate | 2023 |
| THE 1928 Foundation Limited | Other services | 2022 |
| THE Barbers Vision Ltd | Other services | 2026 |
| THE Bladon Farm House Ltd | Real estate | 2014 |
| THE Bosworth Clinic Limited | Health & social care | 2013 |
| THE Bryanston Consultancy Limited | Professional & scientific | 2021 |
| THE Cotswold Shooting Company Ltd | Arts & recreation | 2025 |
| THE Cotswold Tailor Holdings Ltd | Financial services | 2023 |
| THE Cotswold Tailor Ltd | Wholesale & retail | 2012 |
| THE Emotional Help Hub UK Ltd | Health & social care | 2020 |
| THE Full English PUB Company Limited | Hospitality | 2024 |
| THE Garden (Oxford) Limited | Wholesale & retail | 2018 |
| THE Guild of Shareholders Limited | Administrative & support | 1995 |
| THE Lion at Brackley Limited | Hospitality | 2023 |
| THE Long Run | Health & social care | 2015 |
| THE Oxford Outlook Ltd | Wholesale & retail | 2018 |
| THE Star Inn (Woodstock) Limited | Hospitality | 2025 |
| THE Traditional Inn Limited | Hospitality | 2012 |
| THE WAX Removal Clinic Ltd | Health & social care | 2023 |
| THE Woodstock Accountancy Practice Limited | Professional & scientific | 2019 |
| THE Woolhound Ltd | Wholesale & retail | 2021 |
| THE Work Wellbeing Strategist Ltd | Professional & scientific | 2025 |
| Thecarerooms Ltd | Hospitality | 2017 |
| Thomaz Consulting Ltd | Information & communication | 2024 |
| Thomfoodery Limited | Professional & scientific | 2018 |
| Thomson Philanthropy Ltd | Professional & scientific | 2008 |
| Thorncliffe Consulting Limited | Professional & scientific | 2021 |
| Three Mills Consulting Limited | Professional & scientific | 2011 |
| Tilney Roofing Ltd | Construction | 2024 |
| TJ Fellows Ltd | Extraterritorial | 2020 |
| TOM Dark Engineering Limited | Manufacturing | 2002 |
| TOM Rocks Maths Limited | Information & communication | 2025 |
| Top Notch Pirates Ltd | Other services | 2023 |
| Townhouse Executive Travel Limited | Administrative & support | 2008 |
| Trims Fuels Ltd | Agriculture & fishing | 2024 |
| Tubetool Limited | Manufacturing | 2001 |
| Tummy Doctor Ltd | Health & social care | 2020 |
| Turfection Professional Lawn Care Limited | Administrative & support | 2023 |
| Understory Research Ltd | Professional & scientific | 2025 |
| Upstart BIO Ltd | Professional & scientific | 2020 |
| Urbandrop Limited | Real estate | 1987 |
| Urbanoid Services Limited | Real estate | 2016 |
| Urbanoid Workspace Oxford Limited | Real estate | 2004 |
| Vanbrugh Homes Construction Limited | Construction | 2020 |
| Verenia Court Management Company Limited | Other services | 2002 |
| VIV Lambert ELT Limited | Information & communication | 2014 |
| VK Assets Ltd | Information & communication | 2023 |
| Voltainer Ltd | Manufacturing | 2025 |
| W C Roberts & SON Limited | Construction | 2003 |
| Water Brook View Management Company Limited | Households | 2019 |
| West Nally Limited | Arts & recreation | 2005 |
| West Oxfordshire Business Services Limited | Professional & scientific | 2024 |
| Westaby Books Limited | Arts & recreation | 2016 |
| Wild Grace Limited | Wholesale & retail | 2018 |
| Wilkinson Hall Limited | Information & communication | 2019 |
| Williams Sports Tours Ltd | Education | 2026 |