| Setex Global Sourcing Ltd | Wholesale & retail | 2011 |
| Seventeen Projects Ltd | Arts & recreation | 2022 |
| Seventh Sun Limited | Wholesale & retail | 1996 |
| Seventy Severn Performance Ltd | Other services | 2021 |
| Sewardstone Ltd | Administrative & support | 2014 |
| Seychell Consulting Limited | Administrative & support | 2009 |
| SFP Properties Limited | Real estate | 2024 |
| SFT Services Limited | Administrative & support | 2020 |
| SG Commercial Rentals Limited | Real estate | 2017 |
| SG London Engineering Limited | Extraterritorial | 2024 |
| SG Rayner Homes Limited | Real estate | 2018 |
| Sghm Services Limited | Administrative & support | 2014 |
| SGL Co-Packing Limited | Hospitality | 1986 |
| SGT Contracts Ltd | Construction | 2014 |
| SGT Homes Ltd | Real estate | 2024 |
| SGT Invest Ltd | Financial services | 2023 |
| SH & MH Holdings Ltd | Real estate | 2021 |
| SHA Bakhshi Limited | Real estate | 2026 |
| Shaded Candle Company Limited | Manufacturing | 1998 |
| Shafiq Properties Ltd | Real estate | 2022 |
| Shaftesbury Printing & Engraving Ltd | Manufacturing | 2005 |
| Shah & Sons Real Estate Limited | Real estate | 2022 |
| Shah Traders Limited | Wholesale & retail | 2026 |
| Shaheer Ahmed Ltd | Information & communication | 2022 |
| Shaikh Partners Limited | Professional & scientific | 2009 |
| Shailesh's Properties Ltd | Real estate | 2017 |
| Shaka 9 Services Ltd | Professional & scientific | 2022 |
| Shakespear Road Facility Limited | Arts & recreation | 2015 |
| Shakti Akal Real Estates Ltd | Real estate | 2025 |
| Shamliayah Care Ltd | Health & social care | 2023 |
| Shammah & Nissi Arts Ltd | Arts & recreation | 2020 |
| Shannon Productions Limited | Administrative & support | 2007 |
| Shannonandbloom Ltd | Professional & scientific | 2023 |
| Shape London RE Limited | Real estate | 2015 |
| Sharetts School of Motoring Ltd | Education | 2024 |
| Sharevertize Ltd | Administrative & support | 2020 |
| Sharp Curiosity Productions Ltd | Information & communication | 2009 |
| Sharpstyle Limited | Construction | 2007 |
| Shatri Counselling Ltd | Other services | 2025 |
| Shatri Holdings Ltd | Real estate | 2025 |
| Shazi Design & Build Limited | Construction | 2018 |
| Shazia ALI Ltd | Professional & scientific | 2014 |
| Sheba Concepts Limited | Real estate | 1993 |
| Sheibani V C Limited | Financial services | 2024 |
| Sher Legal Services Ltd | Other services | 2015 |
| Sherborne Street Holdings Limited | Real estate | 2026 |
| Sherlock Consultancy Ltd | Professional & scientific | 2004 |
| Sherlock Property Group Ltd | Construction | 2025 |
| Sherry Hair & Beauty Limited | Other services | 2010 |
| Sherry Hair and Beauty Salon Ltd | Other services | 2025 |
| Shet Limited | Information & communication | 2019 |
| Shetty Enterprise Ltd | Wholesale & retail | 2025 |
| Shieldme Solutions Limited | Administrative & support | 2025 |
| Shift Zero Limited | Administrative & support | 2017 |
| Shine Clubs Limited | Administrative & support | 2010 |
| Shingle Services Limited | Administrative & support | 2016 |
| Shire Hall Homes Limited | Construction | 2018 |
| Shirley Properties (Essex) Limited | Real estate | 2019 |
| Shirley Properties Management Limited | Real estate | 2025 |
| Shish Broadway Ltd | Hospitality | 2024 |
| Shiv Cash and Carry Limited | Wholesale & retail | 2018 |
| Shiv Shakti Convenience Ltd | Wholesale & retail | 2024 |
| Shockwave Therapy London Clinic Limited | Health & social care | 2025 |
| Shole Estates Ltd | Real estate | 2010 |
| Shomester Investments Ltd | Real estate | 2021 |
| Shore Home Lettings Ltd | Real estate | 2023 |
| Shoriel Investments 2 Limited | Real estate | 2021 |
| Shoriel Investments 3 Limited | Real estate | 2022 |
| Shoriel Investments Limited | Real estate | 2020 |
| Short Waves Arts CIC | Administrative & support | 2026 |
| Showpower Ltd | Administrative & support | 2016 |
| Showroom Events Company Limited | Administrative & support | 2019 |
| Shrewcruitment Enterprises Limited | Administrative & support | 2017 |
| Shreysar Limited | Health & social care | 2010 |
| Shubh and Labh Limited | Extraterritorial | 2023 |
| Shubh PVT Ltd | Construction | 2025 |
| SI Kale Ltd | Arts & recreation | 2024 |
| SIA Foods Ltd | Construction | 2018 |
| Sibachi Ltd | Real estate | 2021 |
| Sibachi Research Ltd | Professional & scientific | 2021 |
| Sibon Technologies Limited | Information & communication | 2011 |
| Sidhana Limited | Financial services | 2016 |
| Sidooz Consulting Ltd | Professional & scientific | 2025 |
| Sierra Homecare Ltd | Health & social care | 2017 |
| Signature Banqueting Limited | Arts & recreation | 2011 |
| Signature Plastering Ltd | Construction | 2023 |
| Signature Stylez Ltd | Other services | 2026 |
| Siji Limited | Administrative & support | 1999 |
| Silbee Limited | Extraterritorial | 2011 |
| Silent Discos World Limited | Other services | 2023 |
| Silk Route Impex Limited | Wholesale & retail | 2015 |
| Silkgrange Limited | Wholesale & retail | 1980 |
| Silvan Limited | Manufacturing | 1947 |
| Silver Law LLP | | 2004 |
| Silver Practice Limited | Administrative & support | 2022 |
| Silver Star Developments Limited | Real estate | 2015 |
| Silver Star Property Services Limited | Real estate | 2023 |
| Silver Star UK Estates Limited | Real estate | 2016 |
| Silver Tail Commercial Ltd | Real estate | 2026 |
| Silver, Silver & Silver Limited | Administrative & support | 2020 |