| First Abide CIC | Information & communication | 2022 |
| First AID Cover Ltd | Health & social care | 2007 |
| First Call Building Services West Midlands Ltd | Construction | 2019 |
| First Care Services Limited | Health & social care | 2004 |
| First Choice Collective Ltd | Administrative & support | 2020 |
| First Choice Computers (West Midlands) Limited | Information & communication | 1993 |
| First Choice Computers Limited | Extraterritorial | 2004 |
| First Choice Doors & Windows Ltd | Administrative & support | 2017 |
| First Choice Gates Limited | Manufacturing | 2005 |
| First Choice Home Maintenance Ltd | Administrative & support | 2017 |
| First Choice Plumbing Ltd | Construction | 2016 |
| First Choice Telecom Limited | Information & communication | 2017 |
| First City (Holdings) Limited | Administrative & support | 1957 |
| First City Associates (1881) Limited | Professional & scientific | 1995 |
| First City Estate Agents & Town Planning Limited | Professional & scientific | 1987 |
| First City Limited | Professional & scientific | 1983 |
| First City Property Consultants Limited | Professional & scientific | 1993 |
| First Class Learning Tettenhall Ltd | Education | 2024 |
| First Fresh Foods (Wolves) Ltd | Wholesale & retail | 2018 |
| First Fresh Foods Ltd | Wholesale & retail | 2015 |
| First Glass Window Cleaning Ltd | Administrative & support | 2024 |
| First Land Investments Limited | Professional & scientific | 1992 |
| First Link (UK) Ltd | Manufacturing | 1995 |
| First Maintenance Supplies Limited | Wholesale & retail | 2011 |
| First Point Fire and Safety Ltd | Other services | 2015 |
| First Response ARC Ltd | Wholesale & retail | 2026 |
| First Right Limited | Administrative & support | 2021 |
| First Right Property Limited | Real estate | 2024 |
| First Smiles Clinic Ltd | Health & social care | 2025 |
| First Stop (Whitchurch) Ltd | Wholesale & retail | 2014 |
| First Talfourd Street Property Management Company Limited | Households | 1992 |
| First Tier Lending Ltd | Financial services | 2023 |
| First Washbrook Road Management Company Limited | Households | 1991 |
| Firstcall Healthcare Services Ltd | Real estate | 2009 |
| Firstchoice UK Staffing Limited | Administrative & support | 2026 |
| Firstfit Ltd | Administrative & support | 2017 |
| Fisabela Ltd | Wholesale & retail | 2024 |
| Fish and Pond Ltd | Extraterritorial | 2017 |
| Fisher Wealth Management Limited | Financial services | 2017 |
| Fisherman (UK) Music Ltd | Wholesale & retail | 2013 |
| Fishface Cycles Limited | Wholesale & retail | 2012 |
| Fishpost Ltd | Hospitality | 2023 |
| Fista Ltd | Wholesale & retail | 2025 |
| Fit 4 Learning CIC | Education | 2024 |
| Fit and FLO Limited | Wholesale & retail | 2024 |
| Fit Directory Limited | Arts & recreation | 2022 |
| Fit Fast Academy Ltd | Education | 2019 |
| Fit Fast Fitness Ltd | Education | 2023 |
| Fit Pro Done for YOU Digital Marketing Limited | Professional & scientific | 2016 |
| Fitnessmode Limited | Manufacturing | 2025 |
| Fitting Master Ltd | Construction | 2025 |
| Fitz & Kouz Logistics Ltd | Transport & logistics | 2026 |
| Five Capital U.K. Ltd | Financial services | 2026 |
| Five Core Logistics Ltd | Transport & logistics | 2022 |
| Five Corporate Ltd | Construction | 2019 |
| Five Crowns Property Ltd | Real estate | 2018 |
| Five Crowns Services Ltd | Real estate | 2018 |
| Five Holdings Ltd | Administrative & support | 2023 |
| Five Oaks Holdings Ltd | Real estate | 2025 |
| Five Star Auto Service Ltd | Wholesale & retail | 2025 |
| Five Star Nails 28 Ltd | Other services | 2024 |
| Five Star Outfit Ltd | Wholesale & retail | 2026 |
| Five Supplies Ltd | Wholesale & retail | 2025 |
| Five Urban Ltd | Wholesale & retail | 2020 |
| Five White Line Ltd | Information & communication | 2025 |
| Five Wise Solutions Ltd | Professional & scientific | 2024 |
| Five Woods Ltd | Construction | 2021 |
| Fiveways Convenience Store Midlands Ltd | Wholesale & retail | 2016 |
| Fivriv UK Ltd | Hospitality | 2025 |
| FIX N Go Limited | Wholesale & retail | 2025 |
| Fixing Touch Ltd | Other services | 2021 |
| Fixxion Warehouse Project Ltd | Arts & recreation | 2011 |
| FIZ Traders Limited | Wholesale & retail | 2025 |
| Fizzah Foods Limited | Other services | 2018 |
| FJ Autos and MOT Ltd | Other services | 2025 |
| Fjaka Limited | Hospitality | 2023 |
| Fjeng Limited | Health & social care | 2025 |
| Fkmma Limited | Arts & recreation | 2011 |
| Fkontehjula Limited | Health & social care | 2026 |
| Flagz MAS Band C.I.C. | Arts & recreation | 2015 |
| Flair Consultancy Limited | Information & communication | 2009 |
| Flair Films Limited | Information & communication | 2004 |
| Flam Bird Limited | Hospitality | 2020 |
| Flamingo Industries Ltd | Real estate | 2020 |
| Flamingo Pink Limited | Hospitality | 2008 |
| Flash Hostx Ltd | Information & communication | 2025 |
| Flash Web Hosters Ltd | Information & communication | 2025 |
| Flashbox Limited | Wholesale & retail | 2026 |
| Flashdroplogistics Limited | Transport & logistics | 2026 |
| Flatworldworks Limited | Information & communication | 2011 |
| Flavell Precision Engineering Limited | Manufacturing | 1997 |
| Flavours Pizza & Grill Ltd | Hospitality | 2020 |
| Flavourz Desserts Limited | Hospitality | 2024 |
| Flavourz Takeaway Limited | Hospitality | 2019 |
| Fleek Tech Ltd | Wholesale & retail | 2017 |
| Fleet Entertainment Ltd | Hospitality | 2022 |
| Fleet Support Movement Limited | Transport & logistics | 2015 |
| Fleet Support Tyre & Auto Ltd | Wholesale & retail | 2026 |
| Fleet Sync Co Ltd | Information & communication | 2024 |
| Fleet-Fix Solutions Limited | Wholesale & retail | 2023 |