| Sonia & Nikki's Ltd | Wholesale & retail | 2025 |
| Sonia & Paul Limited | Real estate | 2004 |
| Sonia Ruth Limited | Arts & recreation | 2015 |
| Sonias Limited | Wholesale & retail | 2015 |
| Sonic Pro Ltd | Wholesale & retail | 2024 |
| Sonu Mehta Limited | Real estate | 2025 |
| Sony Investments Ltd | Real estate | 2023 |
| Soora Properties Limited | Real estate | 2024 |
| Soori Optical Ltd | Health & social care | 2024 |
| Sophia Romans Limited | Information & communication | 2024 |
| Sophisticos Ltd | Wholesale & retail | 2022 |
| Soppy Healthcare Ltd | Health & social care | 2023 |
| Sorelia Investments Limited | Real estate | 2026 |
| Sorelle Property Investments Limited | Real estate | 2022 |
| Soren Medicals Limited | Health & social care | 2023 |
| Sosa Properties Limited | Real estate | 2020 |
| Sosecommerce Ltd | Wholesale & retail | 2026 |
| Soughtout Safesystems Ltd | Professional & scientific | 2026 |
| Soul 2 Soul Counselling & Holistic Therapies Ltd | Health & social care | 2026 |
| Soul Prosperity Ltd | Arts & recreation | 2025 |
| Soul Search Ltd | Other services | 2018 |
| Soulful Tribe Ltd | Arts & recreation | 2025 |
| Souls Lemonade Ltd | Professional & scientific | 2021 |
| Soult Premium Ltd | Wholesale & retail | 2024 |
| Sound of Distinction Limited | Arts & recreation | 2010 |
| Soundly Electrics (UK) Co. Ltd | Wholesale & retail | 2022 |
| Soundstage and Events UK Limited | Information & communication | 2023 |
| Soundswell Ltd | Professional & scientific | 2012 |
| Soundz Publishing Limited | Information & communication | 2020 |
| Source Appointments Limited | Administrative & support | 2007 |
| Source Coaching Academy Ltd | Professional & scientific | 2025 |
| Soutenir Ltd | Health & social care | 2025 |
| South Staffordshire Industrial Doors Ltd | Construction | 2019 |
| South Staffordshire Narrowboat Company Limited | Administrative & support | 1990 |
| South Staffordshire Properties Limited | Real estate | 2006 |
| South Staffs Roofing Ltd | Construction | 2023 |
| Southdown Consultants Limited | Professional & scientific | 2020 |
| Southern Crossroads Music Limited | Professional & scientific | 2010 |
| Southern Heating Installer Limited | Construction | 2011 |
| Southgate RTM Company Limited | Households | 2006 |
| Southstaffdogs Limited | Education | 2025 |
| Southstand Limited | Administrative & support | 2026 |
| Sovereign Health Limited | Professional & scientific | 2018 |
| Sovereign Services Ltd | Transport & logistics | 2024 |
| Sovereign Truck Bodies Limited | Manufacturing | 2007 |
| SP Art Ltd | Arts & recreation | 2020 |
| SP Building and Maintenance Ltd | Construction | 2022 |
| SP Cargo Ltd | Other services | 2022 |
| SP Chinese Limited | Hospitality | 2024 |
| SP Global Limited | Wholesale & retail | 2026 |
| SP Installation Services Ltd | Construction | 2017 |
| SP Midlands Subway Ltd | Wholesale & retail | 2020 |
| SP Property Services WM Limited | Households | 2017 |
| SP UK Events Ltd | Hospitality | 2025 |
| SP500 Trade Limited | Wholesale & retail | 2025 |
| Spa Premises Limited | Real estate | 2006 |
| Space Audit Systems Ltd | Information & communication | 2018 |
| Space Seal (Midlands) Limited | Manufacturing | 1978 |
| Spaceoasis Limited | Manufacturing | 2000 |
| Spaceship Wolves Limited | Administrative & support | 2017 |
| Spacinfotech Services Ltd | Information & communication | 2023 |
| Spada Group Ltd | Administrative & support | 2020 |
| Sparkcrafters Printers Ltd | Professional & scientific | 2025 |
| Sparkdelight Cleaning Services Ltd | Administrative & support | 2026 |
| Sparkinstant Limited | Professional & scientific | 1937 |
| Sparkle.Buy Limited | Wholesale & retail | 2025 |
| Sparklenest Cleaning Ltd | Administrative & support | 2025 |
| Sparkling and Shine Cleaning Services Ltd | Other services | 2026 |
| Spartan Shuttering Ltd | Construction | 2016 |
| Spax UK Limited | Wholesale & retail | 1997 |
| SPC Active Cards Limited | Manufacturing | 2010 |
| SPC INV Company Ltd | Financial services | 2025 |
| SPC Property Limited | Real estate | 2007 |
| Speake Civils Limited | Professional & scientific | 2023 |
| Speakerbox Rave UK Ltd | Administrative & support | 2025 |
| Speaking Points Ltd | Education | 2022 |
| Special Care Oral Health Partnership Ltd | Professional & scientific | 2026 |
| Specialist Autism Mentoring Ltd | Other services | 2023 |
| Specialist Engineering Solutions Group Limited | Manufacturing | 2026 |
| Specialist Metallic Coatings Limited | Manufacturing | 2016 |
| Specialoj Ltd | Hospitality | 2024 |
| Spectator Seating Ltd | Manufacturing | 2004 |
| Spector Design Ltd | Professional & scientific | 2016 |
| Spectra First Limited | Professional & scientific | 2014 |
| Spectre Medical Services Ltd | Health & social care | 2024 |
| Spectrum Drive Ltd | Transport & logistics | 2025 |
| Spectrum Painting Contractors Limited | Professional & scientific | 2022 |
| Speed Logistics Limited | Transport & logistics | 2025 |
| Speedlight Logistic Ltd. | Wholesale & retail | 2016 |
| Speedsaleproperties Ltd | Real estate | 2021 |
| Speedway Construction Limited | Construction | 2025 |
| Speedway Pets Limited | Wholesale & retail | 2016 |
| Spencer & Co Construction Ltd | Administrative & support | 2020 |
| Spencer Barden Consulting Ltd | Arts & recreation | 2014 |
| Sperian Protection Holding (UK) Ltd | Financial services | 1999 |
| Spha Property Investment Ltd | Real estate | 2024 |
| Spice Balti House Limited | Hospitality | 2021 |
| Spice Lounge T/A RAJ Tandoori Limited | Hospitality | 2019 |
| Spice N' Grains Limited | Wholesale & retail | 2026 |
| Spice of Sylhet Limited | Hospitality | 2022 |