| Skytrace (UK) Limited | Professional & scientific | 1999 |
| Skyway Roofing and Glass Limited | Construction | 2026 |
| SL Portfolio Limited | Real estate | 2026 |
| Slade Developments Group Ltd | Real estate | 2025 |
| Slade Property Collective Ltd | Real estate | 2023 |
| Sladeland Limited | Real estate | 2025 |
| Slam Basketball CIC | Education | 2023 |
| Slaprain Ltd | Administrative & support | 2019 |
| SLB Associates Ltd | Arts & recreation | 2025 |
| SLB Installations Limited | Construction | 2026 |
| SLC7 Ltd | Wholesale & retail | 2025 |
| Slick Stitch Embroidery Company Limited | Manufacturing | 1991 |
| Slick Stitch Holdings Limited | Extraterritorial | 2008 |
| Slim and JAY Ltd | Hospitality | 2018 |
| Slimline Bifold & Windows Ltd | Manufacturing | 2015 |
| SLK Consultancy Limited | Real estate | 2007 |
| Sloganeer Limited | Wholesale & retail | 2023 |
| SLS Haulage Ltd | Transport & logistics | 2025 |
| SLT Driver Hire Midlands Limited | Transport & logistics | 2020 |
| Slvw Ltd | Real estate | 2025 |
| SM Auto Traders Limited | Wholesale & retail | 2022 |
| SM Electrical Midlands Ltd | Construction | 2022 |
| SM Finishing Ltd | Manufacturing | 2019 |
| SM Property Services & Extensions Limited | Construction | 2020 |
| SMA Group Ltd | Administrative & support | 2013 |
| Smart Awning Ltd | Wholesale & retail | 2026 |
| Smart Bodies & Co. Ltd | Wholesale & retail | 2011 |
| Smart Business Space Limited | Households | 2022 |
| Smart Codes Tech Ltd | Information & communication | 2025 |
| Smart Electric Solutions Ltd | Construction | 2023 |
| Smart Ever Shine Ltd | Administrative & support | 2025 |
| Smart Finish Detailing Ltd | Administrative & support | 2026 |
| Smart Glazing Windows Ltd | Construction | 2023 |
| Smart Green Property Ltd | Real estate | 2016 |
| Smart Haven Ltd | Wholesale & retail | 2025 |
| Smart Industrial Space Limited | Households | 2022 |
| Smart Leaders Ltd | Information & communication | 2023 |
| Smart Office Space Limited | Real estate | 2022 |
| Smart One Construction Ltd | Construction | 2019 |
| Smart One DK Properties Ltd | Real estate | 2023 |
| Smart Plastic Card Holdings Ltd | Financial services | 2017 |
| Smart Plastic Cards Ltd | Manufacturing | 2002 |
| Smart Pointer Solutions Limited | Information & communication | 2024 |
| Smart Quality Solutions Limited | Professional & scientific | 2016 |
| Smart Retail Space Limited | Households | 2022 |
| Smart Staffing Solutions Limited | Administrative & support | 2021 |
| Smart Tech Private Ltd | Information & communication | 2015 |
| Smart Trade Live Limited | Transport & logistics | 2016 |
| Smart Transport (Wolv) Ltd | Transport & logistics | 2025 |
| Smart Transportation Ltd | Transport & logistics | 2026 |
| Smart Tribe Digital Limited | Wholesale & retail | 2024 |
| Smart Vehicle Solutions Midlands Ltd | Wholesale & retail | 2025 |
| Smartcare Property Maintenance Ltd | Construction | 2025 |
| Smarter New Beginnings Ltd | Health & social care | 2020 |
| Smartohms Electrical Ltd | Construction | 2017 |
| Smartplan & Facilities Services Ltd | Professional & scientific | 2025 |
| Smashderby Ltd | Hospitality | 2026 |
| Smashed & Pulled Ltd | Hospitality | 2025 |
| Smashed and Pulled Franchising Ltd | Hospitality | 2025 |
| SMC Accounts Ltd | Professional & scientific | 2018 |
| Smestow Direct Limited | Extraterritorial | 2017 |
| SMG Food and Wine Ltd | Wholesale & retail | 2026 |
| SMG Parts Ltd | Transport & logistics | 2013 |
| Smid Ltd | Real estate | 2024 |
| Smiile U Ltd | Health & social care | 2024 |
| Smile Beauty and Hair Ltd | Other services | 2025 |
| Smile ETC Medical East Ltd | Health & social care | 2024 |
| Smile ETC Medical Herts Ltd | Health & social care | 2024 |
| Smile ETC Medical London Ltd | Health & social care | 2024 |
| Smile Forever Limited | Health & social care | 2015 |
| Smile Raves Ltd | Arts & recreation | 2023 |
| Smith Counselling & Coaching Ltd | Professional & scientific | 2021 |
| Smith Squared Holidays Ltd | Hospitality | 2023 |
| Smith's Skips Limited | Water & waste | 2025 |
| Smithridge Healthcare Group Limited | Administrative & support | 2025 |
| Smithridge Healthcare Limited | Administrative & support | 2003 |
| Smithridge Homecare Limited | Health & social care | 2024 |
| Smiths Self Drive Limited | Administrative & support | 2015 |
| Smithsling Ltd | Financial services | 2022 |
| SMK Commercial Ltd | Real estate | 2024 |
| SMK Estates Ltd | Real estate | 2020 |
| Smkr Optics Ltd | Wholesale & retail | 2025 |
| Smoky Sweet Ltd | Wholesale & retail | 2025 |
| Smooth Cactus Ltd | Wholesale & retail | 2025 |
| Smooth Co Ltd | Construction | 2019 |
| SMR Data Services Limited | Information & communication | 2023 |
| SMR Medical Services Limited | Health & social care | 2012 |
| SMS Anaesthetic Services Limited | Health & social care | 2019 |
| SMS Consultancy Ltd | Administrative & support | 2017 |
| SMS Electrical Contractors Limited | Construction | 2017 |
| SMS Midlands Ltd | Financial services | 2025 |
| Smsb Property Management Limited | Real estate | 2025 |
| SMT Health Care Limited | Health & social care | 2014 |
| SMV Vehicle Solutions Ltd | Administrative & support | 2025 |
| Smycken Ltd | Manufacturing | 2019 |
| SN (Wolverhampton) Electrician Ltd | Construction | 2026 |
| SN Estates Ltd | Real estate | 2021 |
| Snack Factory Limited | Professional & scientific | 2013 |
| Snack IT NOW Limited | Wholesale & retail | 2022 |
| Snakebyte UK Ltd | Wholesale & retail | 2009 |