| Shipping and Storage Containers UK Limited | Wholesale & retail | 2022 |
| Shipxpert Ltd | Wholesale & retail | 2025 |
| Shirley Securities Limited | Real estate | 1953 |
| Shirley-Silvesters Limited | Arts & recreation | 2015 |
| Shirtee Ltd | Wholesale & retail | 2026 |
| Shiv Mahadev Construction Ltd | Construction | 2025 |
| Shiv SDA Stars Limited | Real estate | 2022 |
| Shiva Logistics UK Ltd | Transport & logistics | 2025 |
| Shivansh Services Ltd | Wholesale & retail | 2025 |
| Shivaya Wellness Private Limited | Health & social care | 2025 |
| Shivedana Ltd | Health & social care | 2021 |
| Shivoham Local Property Ltd | Real estate | 2025 |
| Shizrah Aesthetics Ltd | Other services | 2023 |
| SHJ Consultancy Solutions Ltd | Administrative & support | 2025 |
| SHM Convenience Store Ltd | Other services | 2013 |
| Shooshabashi Ltd | Hospitality | 2018 |
| Shop and Stock Ltd | Wholesale & retail | 2025 |
| Shop Front, Shutter & Windows Limited | Manufacturing | 2026 |
| Shop-Primus Ltd | Wholesale & retail | 2023 |
| Shopabuddy Ltd | Extraterritorial | 2024 |
| Shopfront Company Ltd | Other services | 2019 |
| Shopfronts&Shutters R US Ltd | Construction | 2022 |
| Shopify Pro Services Limited | Wholesale & retail | 2025 |
| Shopit Ltd | Wholesale & retail | 2026 |
| Shopkedros Limited | Wholesale & retail | 2025 |
| Shopnation Ltd | Wholesale & retail | 2026 |
| Shopula Ltd | Wholesale & retail | 2025 |
| Shopyco Limited | Wholesale & retail | 2025 |
| Shore Reach Solution Ltd | Transport & logistics | 2026 |
| Shore Trading Limited | Wholesale & retail | 2010 |
| Shore-Up Consultancy Limited | Professional & scientific | 2018 |
| Shore-Up Properties Limited | Financial services | 2018 |
| Shorebirds Ltd | Wholesale & retail | 2025 |
| Shoshanna Soul Revival Ltd | Other services | 2025 |
| Show Expo Limited | Construction | 2009 |
| Showfighter UK Limited | Arts & recreation | 2018 |
| SHR Deals Ltd | Wholesale & retail | 2026 |
| Shred Express Limited | Water & waste | 2025 |
| Shrewd Financial Planning Ltd | Financial services | 2015 |
| Shri Durga Bhawan Temple International Limited | Administrative & support | 2007 |
| Shrm People Solutions Ltd | Professional & scientific | 2022 |
| Shropshire Abodes Limited | Real estate | 2024 |
| Shropshire Brick & Stone (UK) Limited | Manufacturing | 2011 |
| Shropshire Building Services Limited | Construction | 2018 |
| Shropshire Coffee Limited | Wholesale & retail | 1991 |
| Shropshire Design Limited | Wholesale & retail | 2012 |
| Shropshire Drains & Groundworks Limited | Construction | 2020 |
| Shropshire Kitchens and Bathrooms Ltd | Construction | 2024 |
| Shropshire Motorcycles Ltd | Wholesale & retail | 2015 |
| Shropshire New and Used Office Furniture Limited | Professional & scientific | 2009 |
| Shropshire Park Management Limited | Administrative & support | 2008 |
| Shropshire Property Search Limited | Professional & scientific | 2009 |
| Shropshire Skin and Laser Ltd | Other services | 2026 |
| Shropshire Stone and Timber Limited | Wholesale & retail | 2022 |
| Shroud Labs Limited | Information & communication | 2026 |
| SHS Property Holding Ltd | Households | 2024 |
| Shuga Budz Limited | Manufacturing | 2013 |
| Shumba Holdings Limited | Health & social care | 2022 |
| Shursh Limited | Wholesale & retail | 2024 |
| Shut Your Mouth Entertainments Limited | Arts & recreation | 2025 |
| Shutter & Glaze Ltd | Construction | 2025 |
| Shzb Ltd | Wholesale & retail | 2026 |
| SI Home Designs Ltd | Wholesale & retail | 2022 |
| Sial Brand Media Ltd | Wholesale & retail | 2024 |
| Sian Computers Community Initiative C.I.C. | Administrative & support | 2017 |
| SIB Homes Ltd | Real estate | 2026 |
| Sibbat Enterprises Ltd | Wholesale & retail | 2026 |
| Sick Products Ltd | Wholesale & retail | 2024 |
| Sickle Cell and Thalassaemia Support Project (Wolverhampton) | Health & social care | 1998 |
| Siculo LAB Ltd | Hospitality | 2021 |
| SID Consulting Ltd. | Information & communication | 2016 |
| Sidak Dhillon Haulage Ltd | Transport & logistics | 2026 |
| Siddhi Retails Limited | Wholesale & retail | 2024 |
| Siddies Ltd | Wholesale & retail | 2025 |
| Side by Side Hairstylist Ltd | Other services | 2023 |
| Sidhu Company & Property Limited | Real estate | 2019 |
| Sidhu Constructions (Midlands) Ltd | Construction | 2022 |
| Sidhu Limited | Transport & logistics | 1993 |
| Sidhu Properties & Rentals Ltd | Real estate | 2024 |
| Sidhuam Ltd | Health & social care | 2024 |
| Sidhus Transport Ltd | Transport & logistics | 2025 |
| Sidney Store Limited | Wholesale & retail | 2018 |
| Sidra Oilfield Services Limited | Professional & scientific | 2025 |
| Sidrah a Ltd | Hospitality | 2024 |
| Sidris Group Ltd | Information & communication | 2004 |
| Sidris Properties Limited | Information & communication | 2016 |
| Siegeit Ltd | Information & communication | 2025 |
| Siena Transport Ltd | Transport & logistics | 2023 |
| Sigma Circular Recovery Services Ltd | Water & waste | 2023 |
| Sigma Health Group Limited | Health & social care | 2023 |
| Sigma Home Solutions Limited | Administrative & support | 2010 |
| Sigma Occupational Health Ltd | Health & social care | 2022 |
| Sigma Traders Pro Ltd | Wholesale & retail | 2026 |
| Sigma Wealth Partners Ltd | Financial services | 2015 |
| Sigmasafe Solutions Ltd | Education | 2023 |
| Sign Trading Ltd | Manufacturing | 2026 |
| Signature Motorhomes Limited | Wholesale & retail | 2007 |
| Signs NOW UK Limited | Manufacturing | 1996 |
| Sikh Utilites Ltd | Financial services | 2024 |
| Sikhi Bazaar Ltd | Wholesale & retail | 2025 |