| Design Pitstop Limited | Construction | 2024 |
| Designs by Laura Jane Ltd | Manufacturing | 2017 |
| Designs for Living Castle View Ltd | Wholesale & retail | 2025 |
| Designs for Living Interiors Limited | Wholesale & retail | 2005 |
| Desilian Limited | Wholesale & retail | 2019 |
| Dessertmaid Ltd | Hospitality | 2021 |
| DEV Pare Ltd | Wholesale & retail | 2023 |
| Devisolutions Ltd | Information & communication | 2015 |
| Devman Solutions Limited | Information & communication | 2015 |
| Devotel UK Ltd | Information & communication | 2024 |
| Dewey Properties Ltd | Real estate | 2024 |
| DFX Properties Limited | Real estate | 2023 |
| DG Events Management Limited | Administrative & support | 2017 |
| DGE Ltd | Real estate | 2015 |
| Dgrair.Com Ltd | Information & communication | 2011 |
| DGS Tech Limited | Information & communication | 2018 |
| Dhanvantari Solutions Limited | Information & communication | 2014 |
| DHF Property Group Limited | Construction | 2015 |
| DHG Consulting Ltd | Professional & scientific | 2022 |
| Diabetacare Limited | Health & social care | 2011 |
| Diagonal Ltd | Professional & scientific | 2017 |
| Diamond Executive Chauffeurs Ltd | Transport & logistics | 2024 |
| Diamond Nails Boutique Ltd | Other services | 2026 |
| Dibley Consulting Limited | Professional & scientific | 2011 |
| Dibley Holdings Limited | Real estate | 2025 |
| Dick Foster Limited | Professional & scientific | 2010 |
| Dicky T Limited | Professional & scientific | 2011 |
| Diffraction Consulting Ltd | Professional & scientific | 2022 |
| Diggecard UK Ltd | Administrative & support | 2018 |
| Diggerwise Ltd | Administrative & support | 2018 |
| Digicon Global Ltd | Professional & scientific | 2025 |
| Digifact Limited | Financial services | 2022 |
| Digisearch Online Limited | Administrative & support | 2017 |
| Digital and ALL Ltd | Information & communication | 2021 |
| Digital Currencies Governance Group Limited | Information & communication | 2022 |
| Digital Geotechnical Ltd | Professional & scientific | 2021 |
| Digital OFF Market LLP | | 2026 |
| DIM Yeung Limited | Manufacturing | 2026 |
| Dinton Reach Management Company Limited | Households | 2016 |
| Direct Copier Solutions Ltd | Wholesale & retail | 2026 |
| Direct Sight (Amersham) Ltd | Wholesale & retail | 2020 |
| Direction Learning Ltd | Education | 2021 |
| Direction Training Associates Ltd | Education | 2012 |
| Discom Limited | Professional & scientific | 2025 |
| Discover Difference Psychology Clinic Ltd | Health & social care | 2022 |
| Discover South America Ltd | Administrative & support | 2012 |
| Discoverer Pictures Limited | Information & communication | 2011 |
| Distinct Wealth Management Services Ltd | Professional & scientific | 2014 |
| Divecrew Training 2012 Limited | Education | 2012 |
| Diversifhi Limited | Professional & scientific | 2024 |
| Diversity Hub Ltd | Public administration | 2025 |
| Divine Enablement Limited | Health & social care | 2022 |
| Divine Integration Ltd. | Construction | 2012 |
| Divine Property Investments Limited | Real estate | 2019 |
| Divsun Ltd | Health & social care | 2024 |
| Divytech Solutions Limited | Information & communication | 2014 |
| Dixon Digital Marketing Ltd | Professional & scientific | 2024 |
| DJ and Sons Ltd | Manufacturing | 2025 |
| Djamah Conseil Ltd | Information & communication | 2025 |
| Djawdi Consulting Ltd | Information & communication | 2025 |
| DJR Building Ltd | Construction | 2018 |
| DK Capital Estates Ltd | Real estate | 2024 |
| DKG Pest Control Ltd | Agriculture & fishing | 2014 |
| DLM Construction Management Ltd | Construction | 2023 |
| DLP Facilities Maintenance Limited | Construction | 2015 |
| DLX London Ltd | Professional & scientific | 2023 |
| DM Cager (Auto Enrolment) Limited | Administrative & support | 2014 |
| DMA Property Maintenance Ltd | Construction | 2026 |
| Dmpm Consultancy Limited | Professional & scientific | 2017 |
| Doctor Plus Ltd | Health & social care | 2016 |
| Document Vault Systems Limited | Information & communication | 2017 |
| Dog Trouble Foundation CIC | Administrative & support | 2018 |
| Dog Trouble Limited | Wholesale & retail | 2018 |
| Doles Farm Ltd | Agriculture & fishing | 2020 |
| Dolly's Delights Pet Ltd | Wholesale & retail | 2024 |
| Domestic Mini Piling Services Ltd | Construction | 2024 |
| DON Agave Limited | Wholesale & retail | 2024 |
| Don'T Spill Paint Ltd | Wholesale & retail | 2026 |
| Donald Reid Group Limited | Professional & scientific | 2005 |
| Donald Reid Limited | Professional & scientific | 1988 |
| Donegan Consulting Limited | Financial services | 2015 |
| Donna G Ltd | Wholesale & retail | 2021 |
| DOOR94 Limited | Health & social care | 2024 |
| Doringo Properties LLP | | 2020 |
| Dorneywood Close (Burnham) Management Company Limited | Households | 2015 |
| Dorscardi Ltd | Professional & scientific | 2015 |
| Doryame Limited | Administrative & support | 2018 |
| DOS Architects Limited | Professional & scientific | 2005 |
| Doscap Limited | Real estate | 2019 |
| DOT 4 Distribution Ltd | Wholesale & retail | 2013 |
| Double C Stays Limited | Real estate | 2026 |
| Double D Industries Ltd | Information & communication | 2023 |
| Douglas IT Consultants Ltd | Information & communication | 2018 |
| Dovedale Marketing Services Limited | Professional & scientific | 2000 |
| Doverlink Properties Ltd | Real estate | 2020 |
| DOW Schofield Watts (Thames Valley) Partners Limited | Financial services | 2021 |
| Download Podcasts Ltd | Information & communication | 2025 |
| Doyle House Management Company (Crowthorne) Limited | Real estate | 2008 |
| DP Hospitality Ltd | Hospitality | 2026 |
| DPT Investments Ltd | Real estate | 2022 |