| Shinwari Spice Ltd | Hospitality | 2025 |
| Shipping Technologies Ltd | Information & communication | 2019 |
| Shivdhri Properties Limited | Real estate | 2020 |
| Shoaib Bashir Ltd | Arts & recreation | 2024 |
| Shobi Coffee Ltd | Hospitality | 2025 |
| Shop at Thames Limited | Wholesale & retail | 2020 |
| Shoppingmadeeasy Ltd | Wholesale & retail | 2023 |
| Shopsmart Agency Limited | Administrative & support | 2008 |
| Shoptopia Limited | Wholesale & retail | 2021 |
| Shoreston Hall Ltd | Construction | 2022 |
| Shri Toys Limited | Wholesale & retail | 2025 |
| Shuklam Solutions London Ltd | Information & communication | 2014 |
| Shungu Care Limited | Health & social care | 2017 |
| Shynefest Ltd | Arts & recreation | 2018 |
| SI Premium Services Ltd | Wholesale & retail | 2024 |
| Siama BB Ltd | Health & social care | 2025 |
| Siamb Ltd | Wholesale & retail | 2023 |
| Siavo Limited | Real estate | 2016 |
| Sibbick Webster Design Limited | Professional & scientific | 1998 |
| Sidgrove Live Limited | Arts & recreation | 2020 |
| Sidhu & Sidhu Ltd | Real estate | 2016 |
| Sidhu Brothers Property Limited | Real estate | 2008 |
| Sidi Physio Limited | Health & social care | 2013 |
| Sidwell Holdings Limited | Wholesale & retail | 2020 |
| SIG RAY Limited | Professional & scientific | 2016 |
| Sigbot Ltd | Information & communication | 2026 |
| Sigma 3 Ltd | Professional & scientific | 2018 |
| Sigma Air Ltd | Wholesale & retail | 2025 |
| Signature Projects Limited | Construction | 2013 |
| Signintech Ltd | Information & communication | 2009 |
| Silicon Construction Ltd | Households | 2013 |
| Silicon Property Management Ltd | Households | 2017 |
| Silken Street Limited | Wholesale & retail | 2025 |
| Silva & Filhos Ltd | Other services | 2013 |
| Silver Birch Hire Limited | Transport & logistics | 2026 |
| Silver Wealth Management Limited | Professional & scientific | 2020 |
| Silver Wing Lake Limited | Arts & recreation | 2018 |
| Simin Beauty Limited | Other services | 2020 |
| Simon Howard Commercials Limited | Wholesale & retail | 1997 |
| Simple Solutions Plumbing and Heating Ltd | Construction | 2016 |
| Simply B Property Services Ltd | Administrative & support | 2021 |
| Simply Cakebox Limited | Wholesale & retail | 2026 |
| Simply Dine Limited | Hospitality | 2009 |
| Simplyphi Group Limited | Financial services | 2026 |
| Simplyphi Property Ltd | Real estate | 2026 |
| Simulacron Limited | Information & communication | 2025 |
| Sincere Drinks Limited | Manufacturing | 2019 |
| Sinclair Investments Limited | Real estate | 2021 |
| Sindhi Unity Forum World Sindhi Congress CIC | Other services | 2024 |
| Sino Bedrooms Ltd | Other services | 2021 |
| Sinta Group Limited | Administrative & support | 2024 |
| Sintalia Ltd | Professional & scientific | 2024 |
| Sinuessa Pizza & Spaghetti House Limited | Hospitality | 1976 |
| Siphai Group Limited | Wholesale & retail | 2025 |
| SIR John Jackson Limited | Real estate | 1898 |
| Sirius Design Limited | Professional & scientific | 2001 |
| Sisan Construction Limited | Construction | 2000 |
| Sister’S Brother Ltd | Wholesale & retail | 2025 |
| Situs Search Ltd | Administrative & support | 2017 |
| Sivan Properties Ltd | Real estate | 2024 |
| Sixes and Sevens J.R. Limited | Extraterritorial | 2003 |
| Sixtyone Consulting Limited | Administrative & support | 2012 |
| Siyk Ltd | Wholesale & retail | 2023 |
| Siyuangong Productions Limited | Arts & recreation | 2025 |
| SJ Activation Ltd | Administrative & support | 2025 |
| SJ Advisers Limited | Professional & scientific | 2010 |
| SJ Holidays Ltd | Hospitality | 2010 |
| SJ Rowley Ltd | Information & communication | 2023 |
| SJK Hospitality Solutions Ltd | Professional & scientific | 2018 |
| Sjmy Limited | Information & communication | 2024 |
| SJN Capital Ltd | Information & communication | 2022 |
| SK Goods International Limited | Wholesale & retail | 2026 |
| SK Goods Ltd | Wholesale & retail | 2025 |
| SK Programme Solutions Ltd | Administrative & support | 2026 |
| SK Schtrac Consultancy Services Limited | Information & communication | 2024 |
| SK01 Services Ltd | Construction | 2023 |
| Skaccounting Ltd | Professional & scientific | 2025 |
| Skapor Ltd | Wholesale & retail | 2025 |
| Skies Home Care Ltd | Health & social care | 2018 |
| Skilllink Services Ltd | Professional & scientific | 2016 |
| Skin Cupid Limited | Wholesale & retail | 2021 |
| Skinsentials Ltd | Wholesale & retail | 2016 |
| Skipper Solutions Ltd | Professional & scientific | 2024 |
| SKM Property Services Limited | Real estate | 2018 |
| Skoil Consulting Limited | Professional & scientific | 2022 |
| SKS Real Estates Limited | Real estate | 2016 |
| Skulpt Ltd | Health & social care | 2019 |
| Sky Nasa Ltd | Professional & scientific | 2015 |
| Skyblue Avenues Properties Limited | Real estate | 2018 |
| Skyblue Care Services Ltd | Health & social care | 2019 |
| Skybounce Limited | Information & communication | 2023 |
| Skybound Aerial Studios Ltd | Arts & recreation | 2024 |
| Skycrest Projects Limited | Construction | 2014 |
| Skylake Carpentry Limited | Construction | 2021 |
| Skylake Nurseries Limited | Education | 2015 |
| Skyline IT Services Limited | Administrative & support | 2002 |
| Skyline Studios Limited | Arts & recreation | 2018 |
| Skyview Security Ltd | Administrative & support | 2013 |
| Sladden Brothers Limited | Other services | 2007 |
| SLC Sest Holdings Ltd | Transport & logistics | 2026 |