| Salequad Ltd | Manufacturing | 2021 |
| Sales in Practice Limited | Administrative & support | 2013 |
| Salesworx Recruitment UK Ltd | Administrative & support | 2021 |
| Sally Hinder Limited | Administrative & support | 2007 |
| Salt and Bracken Agencies Limited | Wholesale & retail | 2012 |
| Saltedfish Ltd | Professional & scientific | 2020 |
| Salute to the Forces Community Interest Company | Administrative & support | 2025 |
| SAM Beare Hospice | Health & social care | 2006 |
| Samantha Bartlett Interiors Ltd | Professional & scientific | 2021 |
| Samanya Yoga Limited | Arts & recreation | 2011 |
| Samuel Gulliver & Co. Limited | Wholesale & retail | 2018 |
| Sana Care Services Limited | Health & social care | 2018 |
| Sana Recruitment Limited | Administrative & support | 2022 |
| Sanchezlife Ltd | Professional & scientific | 2026 |
| Sanctity Trust | Health & social care | 2012 |
| Sanctuary Play Therapy Ltd | Health & social care | 2025 |
| Sanctum Childrens Services Ltd | Health & social care | 2025 |
| Sandbanks Jets Limited | Transport & logistics | 2020 |
| Sandchar Global Ltd | Professional & scientific | 2026 |
| Sandleon Ltd | Professional & scientific | 2001 |
| Sandown Games Limited | Professional & scientific | 2018 |
| Sanity Corporation Limited | Arts & recreation | 2023 |
| Sanmarton (Holdings) Limited | Financial services | 2020 |
| Sanrus Engineering Services Ltd | Professional & scientific | 2011 |
| Santos Driveways & Paving Ltd | Construction | 2021 |
| SAP Logic Limited | Information & communication | 2012 |
| SAP Supplies Ltd | Wholesale & retail | 2023 |
| Saphirex Ltd | Wholesale & retail | 2022 |
| Sapien Tech Ltd | Professional & scientific | 2025 |
| Sapphire Express Ltd | Wholesale & retail | 2025 |
| Sara & Family Ltd | Real estate | 2021 |
| Sarah Kemp Communications Limited | Information & communication | 2017 |
| Sarah Pearson Financial Ltd | Professional & scientific | 2025 |
| Sarasman Limited | Financial services | 2026 |
| Saravana Ganeson Ltd | Professional & scientific | 2022 |
| Sarsen Health Ltd | Health & social care | 2007 |
| Sarth Consultancy Ltd | Professional & scientific | 2022 |
| Sarwals News Limited | Wholesale & retail | 2026 |
| Sasha Physiotherapy Limited | Health & social care | 2012 |
| Sasholi Electrical Services Limited | Construction | 2026 |
| Sasikala Constructions Ltd | Construction | 2017 |
| Saspn Limited | Health & social care | 2018 |
| Saspo Tourism Services Limited | Administrative & support | 1988 |
| Satoru Data Ltd | Information & communication | 2020 |
| Saughtonhall Holdings Ltd | Real estate | 2015 |
| Saunderton Plotholders Limited | Real estate | 2012 |
| SAV Holding (UK) Limited | Professional & scientific | 1996 |
| SAV Propco Limited | Real estate | 2026 |
| Savage Bros Building Services Limited | Construction | 2013 |
| Savage Legal Limited | Professional & scientific | 2019 |
| Savahna Textiles Ltd | Wholesale & retail | 2025 |
| Savannah Cole Holdings Ltd | Professional & scientific | 2023 |
| Savoy Theatre Group Limited | Arts & recreation | 2005 |
| Savoy Theatre Limited | Arts & recreation | 1897 |
| Sawyer Group Ltd | Professional & scientific | 2025 |
| Saxon Building Ltd | Construction | 2017 |
| Sayapatri Nepali Cultural Group UK | Arts & recreation | 2016 |
| SAZ Drinks Ltd | Wholesale & retail | 2023 |
| Sazh Property Management Ltd | Real estate | 2024 |
| SB Construction Consultancy Ltd | Professional & scientific | 2024 |
| SB Signature Homes Ltd | Real estate | 2012 |
| SB24 Ltd | Professional & scientific | 2021 |
| SB4 Brothers London Ltd | Hospitality | 2026 |
| SB4 Brothers Ltd | Hospitality | 2024 |
| SB58 Real Estate Limited | Construction | 2024 |
| SBL Payroll Ltd | Transport & logistics | 2024 |
| SBN Veterinary Services Ltd | Extraterritorial | 2025 |
| SBR AF Limited | Real estate | 2023 |
| SBR HV Limited | Real estate | 2025 |
| SBR Mdsn Limited | Real estate | 2023 |
| SBR WB Limited | Real estate | 2022 |
| Scale Nest Ltd | Professional & scientific | 2022 |
| Scandinavian Skin Clinic Limited | Other services | 2025 |
| SCF Accountancy Ltd | Professional & scientific | 2025 |
| Scholes Plotholders Limited | Real estate | 2012 |
| Schools Alliance for Excellence | Education | 2019 |
| Schuil Family Property Limited | Real estate | 2017 |
| SCJ Education Consulting Ltd | Administrative & support | 2023 |
| Scommerce Mage Ltd | Information & communication | 2013 |
| Scortaurzcars Ltd | Transport & logistics | 2019 |
| Scott Jeal Building Contractors Limited | Construction | 2003 |
| Scotts Roofing and Leadwork Specialists Limited | Construction | 2026 |
| Screen Pages Holdings Limited | Information & communication | 2008 |
| Screen Pages Limited | Information & communication | 1995 |
| Script LAB Ltd | Information & communication | 2022 |
| Scroll Stopper Co Limited | Professional & scientific | 2026 |
| Scéne Online Ltd | Wholesale & retail | 2025 |
| SD Props Ltd | Information & communication | 2013 |
| SDB Capital Advisors Ltd | Professional & scientific | 2024 |
| SDB Fabrications Limited | Construction | 2006 |
| SDG Capital Ltd | Financial services | 2017 |
| SDS Protection (Holdings) Limited | Financial services | 2019 |
| SDS Protection Ltd | Wholesale & retail | 2019 |
| Sdsg Limited | Information & communication | 2011 |
| Sea Clark Limited | Professional & scientific | 2024 |
| Sean Carey and Company Limited | Professional & scientific | 2018 |
| Seandrew Ltd | Information & communication | 2008 |
| Seaprop Limited | Other services | 2014 |
| Searchlight Counselling & Therapy Ltd. | Health & social care | 2000 |
| Seasonal Transformations Limited | Wholesale & retail | 2022 |