| Rosecote Limited | Real estate | 2021 |
| Rosie Lillis Communications Limited | Professional & scientific | 2019 |
| Rosier Energy Limited | Professional & scientific | 2024 |
| Ross Poulter Roofing Limited | Construction | 2019 |
| Rothney INV001 Limited | Extraterritorial | 2017 |
| Rothney Investments Ltd | Hospitality | 2018 |
| Rotiu and Co. Limited | Wholesale & retail | 2019 |
| Roundagain Limited | Manufacturing | 1993 |
| Roundtower Holdings Ltd | Financial services | 2023 |
| Roundtower Vale Ltd | Agriculture & fishing | 2025 |
| Roundwood Vale Ltd | Real estate | 2025 |
| ROW Zambezi Limited | Arts & recreation | 2016 |
| Rowan Mersh Ltd | Arts & recreation | 2015 |
| Rowes Newsmarket Limited | Wholesale & retail | 2012 |
| Rowles Roofing and Leadworks Limited | Construction | 2016 |
| ROY Barrett & Sons Limited | Professional & scientific | 2006 |
| RP Securities Limited | Wholesale & retail | 2014 |
| Rpas Heroes CIC | Education | 2024 |
| RPL Joinery & Construction Ltd | Manufacturing | 2019 |
| RPS Storage Ltd | Transport & logistics | 2023 |
| Rqmis AR Ltd | Professional & scientific | 2013 |
| RRB Group Limited | Financial services | 2023 |
| RRDBMS-0851-OX169SD Ltd | Construction | 2022 |
| RS FIC Ltd | Financial services | 2026 |
| RS Global Investment Ltd | Wholesale & retail | 2012 |
| Rsckmedical Ltd | Health & social care | 2020 |
| RSM Property Solutions Limited | Administrative & support | 2024 |
| RSR EOT Ltd | Professional & scientific | 2025 |
| RSS Eynsham Ltd | Hospitality | 2018 |
| RT Finance Limited | Administrative & support | 2018 |
| RT Systems and Solutions Limited | Information & communication | 2012 |
| Rtkbang Services Ltd | Administrative & support | 2024 |
| Ruke Ltd | Administrative & support | 2017 |
| RUM Riddimz Run Ltd | Hospitality | 2021 |
| Runlevel Consulting Limited | Information & communication | 2014 |
| Running Reborn Limited | Arts & recreation | 2019 |
| Rupo Elan Ltd | Information & communication | 2025 |
| Rural Business Solutions LLP | | 2003 |
| Russell Harrison Ltd | Real estate | 1998 |
| Ruthless Logistics 09 Ltd | Transport & logistics | 2025 |
| RW Domestic Appliances Ltd | Other services | 2018 |
| Rzsc Limited | Arts & recreation | 2017 |
| S & G James Ltd | Other services | 2013 |
| S & R Exley Building Services Ltd | Construction | 2025 |
| S & T Cotswold Plumbing & Heating Ltd | Construction | 2021 |
| S Aldridge Re-Fit Ltd | Construction | 2011 |
| S C Ayling Ltd | Manufacturing | 2007 |
| S G Installations (Oxford) Ltd | Construction | 2014 |
| S Harris Carpentry Limited | Construction | 2011 |
| S Hellier Gastroenterology Ltd | Health & social care | 2026 |
| S L Medtech Consulting Ltd | Professional & scientific | 2020 |
| S P a Joinery Ltd | Manufacturing | 2010 |
| S W Unwin Ltd | Wholesale & retail | 2021 |
| S&C Stone Holdings Limited | Financial services | 2022 |
| S&C Stone Properties Limited | Real estate | 2024 |
| S&D Health Solutions Ltd | Health & social care | 2026 |
| S.B. Engineering Services Limited | Manufacturing | 2004 |
| S.E Electrical Services Limited | Construction | 2015 |
| S27 Industrial Services Limited | Transport & logistics | 2012 |
| S4TCH Holdco Limited | Financial services | 2025 |
| Saber Learning Ltd | Professional & scientific | 2013 |
| Safe Escape Services Limited | Construction | 2005 |
| Safety Awards Ltd | Professional & scientific | 2024 |
| Safety Services (U.K.) Limited | Professional & scientific | 1985 |
| Safety Services Holdings Limited | Professional & scientific | 2006 |
| Sage Gray Architects Limited | Professional & scientific | 2019 |
| Sailing Miles.Com Limited | Other services | 2025 |
| Saint Andrews Limited | Health & social care | 2009 |
| SAL E MEL Ltd | Hospitality | 2025 |
| Salamandersoft Limited | Information & communication | 2007 |
| Salles Cleaning Services Ltd | Administrative & support | 2024 |
| Sally Travels Limited | Administrative & support | 2023 |
| Salt Lane (Postcombe) Management Company Limited | Households | 2020 |
| Saltmarsh and Druce Ltd | Real estate | 1959 |
| Samash Surgical Limited | Wholesale & retail | 2026 |
| Samber Technology Limited | Information & communication | 2023 |
| Sampan Ltd | Professional & scientific | 2021 |
| Sampo Limited | Information & communication | 2018 |
| Samuel KEW Limited | Construction | 2026 |
| Samuel Storage Ltd | Transport & logistics | 2020 |
| SAN Studio Collective Ltd | Other services | 2023 |
| Sandbox 140 Aldersgate Limited | Real estate | 2024 |
| Sandbox Borough Limited | Real estate | 2023 |
| Sandbox Colechurch House Limited | Real estate | 2025 |
| Sandbox Developments Ltd | Administrative & support | 2020 |
| Sandbox Group Limited | Financial services | 2023 |
| Sandbox London Bridge Limited | Real estate | 2024 |
| Sandbox Shoreditch Limited | Real estate | 2024 |
| Sandbox Southwark Bridge Limited | Real estate | 2024 |
| Sanders House Management Limited | Real estate | 2004 |
| Sandi Safe Ltd | Manufacturing | 2026 |
| Sandum Ltd | Health & social care | 2022 |
| Sanpark (UK) Limited | Manufacturing | 2018 |
| Santos Cleaning Services Ltd | Administrative & support | 2024 |
| Sara Louise Kakes Limited | Manufacturing | 2003 |
| Sarina Home Fabrics Ltd | Wholesale & retail | 2019 |
| Sartorelli's Ltd | Hospitality | 2021 |
| Sassi Ltd | Wholesale & retail | 2018 |
| Satara Capital Partners Ltd | Other services | 2015 |
| Save Wild Tigers Partnership Limited | Other services | 2015 |