| Sami's Wishaw Limited | Hospitality | 2022 |
| Samra Offsales Ltd | Wholesale & retail | 2013 |
| Sandra Lindsay Consulting Limited | Professional & scientific | 2026 |
| Sara Market Ltd | Wholesale & retail | 2026 |
| Sattar Rentals Ltd | Real estate | 2022 |
| SB & AS Holdings Ltd | Construction | 2016 |
| SC047124 Limited | Manufacturing | 1969 |
| Sccc Limited | Professional & scientific | 2025 |
| Scenic Stays Scotland Ltd | Hospitality | 2021 |
| SCM Corporation Limited | Wholesale & retail | 2026 |
| Scot-Clan Services Group Limited | Administrative & support | 2025 |
| Scott Drive Limited | Transport & logistics | 2018 |
| Scott Mcfall Accident Repair Company Limited | Wholesale & retail | 1980 |
| Scott.Co (Glasgow) Ltd | Wholesale & retail | 2017 |
| Scotvalue Limited | Wholesale & retail | 2026 |
| Scoular Transport Limited | Transport & logistics | 2015 |
| Scruffed UP Limited | Other services | 2021 |
| Select Contracts (Scotland) Limited | Construction | 2010 |
| Select Online Trading Limited | Wholesale & retail | 2024 |
| Select Premier Letting Limited | Real estate | 2012 |
| Semper Verax Medics Ltd | Health & social care | 2025 |
| Sentinal Developments Limited | Information & communication | 2025 |
| Sentinel Law Limited | Administrative & support | 2006 |
| SEO Trading Limited | Professional & scientific | 2024 |
| Serenity Beauty and Wellness Limited | Other services | 2025 |
| Sextons Transport Services Limited | Transport & logistics | 1992 |
| SG & Sons Roofing LLP | | 2016 |
| Shad KS Ltd | Wholesale & retail | 2026 |
| Shadow Variation Limited | Other services | 2019 |
| Shaf Property Management Services Ltd | Households | 2022 |
| Shafi 307 Ltd | Wholesale & retail | 2025 |
| Shan Nath Retail Ltd | Wholesale & retail | 2017 |
| Shear Electrical Ltd | Construction | 2024 |
| Sheblooms Advisory Partnership Ltd | Education | 2026 |
| Shemek Electrical Services Ltd | Construction | 2024 |
| Sherlock Caterers Ltd | Hospitality | 2019 |
| Shieldmuir Property Holdings Ltd | Real estate | 2025 |
| Ship Shape (Masonry) Ltd | Construction | 2012 |
| Shire Produce Limited | Wholesale & retail | 2008 |
| Shop N Show Ltd | Wholesale & retail | 2026 |
| Sirram Veterinary Services Limited | Professional & scientific | 2014 |
| SJ Chalmers Properties Ltd | Real estate | 2021 |
| SK Shine Scotland Ltd | Administrative & support | 2023 |
| SK Stores Limited | Wholesale & retail | 2016 |
| SK73 Transport Limited | Transport & logistics | 2021 |
| Skillz 2 Success Ltd | Professional & scientific | 2020 |
| Sky Nails 68 Ltd | Other services | 2026 |
| Skylar Storage Ltd | Transport & logistics | 2021 |
| SL Electrical (Scotland) Limited | Construction | 2003 |
| SM Van Services Glasgow Ltd | Transport & logistics | 2023 |
| SM Van Services Ltd | Transport & logistics | 2020 |
| Smart Valeting Centre Ltd | Wholesale & retail | 2019 |
| Smartcb Ltd | Hospitality | 2019 |
| Smcs Consulting Ltd | Education | 2020 |
| SMG Trader Limited | Wholesale & retail | 2024 |
| Smith Design Solutions Limited | Information & communication | 1993 |
| Smokin Guns Fitness Ltd | Arts & recreation | 2010 |
| Sohal Bros Ltd | Construction | 2026 |
| Solar Connections Scotland Limited | Professional & scientific | 2024 |
| Solar Gymnastics Ltd | Education | 2023 |
| Solidgoods Ltd | Wholesale & retail | 2025 |
| Solution Hair Ltd | Other services | 2025 |
| Specialist Building & Asbestos Services Limited | Construction | 2007 |
| Spice of Life Wishaw Limited | Hospitality | 2018 |
| Splash HCW Ltd | Administrative & support | 2026 |
| Splash Monkey Limited | Administrative & support | 2025 |
| SR Commercial (Scotland) Limited | Wholesale & retail | 2006 |
| SRN Logistics Limited | Transport & logistics | 2022 |
| SRX Logistics Ltd | Transport & logistics | 2026 |
| SS Cheema Limited | Wholesale & retail | 2023 |
| SSL CAD Services Limited | Professional & scientific | 2025 |
| ST Angels Letting Ltd | Real estate | 2021 |
| Star Resources Limited | Wholesale & retail | 2025 |
| Star Shine Valeting Ltd | Other services | 2014 |
| Stefano's (Drumchapel) Ltd | Hospitality | 2004 |
| Stentors Group Ltd | Households | 2020 |
| Steven Bryce Detailing Ltd | Wholesale & retail | 2020 |
| Steven Mcfarlane Design Ltd | Wholesale & retail | 2021 |
| Stevie G Ltd | Transport & logistics | 2019 |
| Stewarton Memorials Limited | Other services | 2009 |
| Strategiq Analytics Ltd | Information & communication | 2024 |
| Strathclyde CPC Training Limited | Other services | 2013 |
| Strathclyde Industrial Units Limited | Administrative & support | 2026 |
| Strathmore Building Supplies Limited | Wholesale & retail | 2019 |
| Strathmore Property Consultants Ltd | Professional & scientific | 2020 |
| Strawberry Properties (Scotland) Ltd | Other services | 2023 |
| Street Flavour Limited | Hospitality | 2025 |
| Strontian Stores Limited | Wholesale & retail | 2025 |
| Structura Contracts Ltd | Construction | 2026 |
| STUDIO1HD Limited | Other services | 2015 |
| Summer Jane Jewellery Ltd | Wholesale & retail | 2025 |
| Support for Ordinary Living | Health & social care | 1998 |
| Survtech-It Ltd | Professional & scientific | 2012 |
| Sustainable Window Solutions Ltd | Construction | 2012 |
| Sustainable Windows Ltd | Construction | 2019 |
| Swissmatic Limited | Manufacturing | 1979 |
| T & R Contracts (UK) Ltd | Real estate | 2017 |
| T 4 Home Ltd | Construction | 2022 |
| T C I B LLP | | 2004 |
| T&E Avanti Ltd | Wholesale & retail | 2015 |