| Russell & SON (Farmers) Limited | Agriculture & fishing | 1985 |
| Russell Clarke Ltd | Administrative & support | 2007 |
| RV Security Ltd | Financial services | 2019 |
| RVS Management Services Limited | Professional & scientific | 2016 |
| RW Landscaping Ltd | Administrative & support | 2012 |
| S & C Properties EA Limited | Real estate | 2024 |
| S & E Allison Limited | Professional & scientific | 2013 |
| S & K Developments Ltd | Construction | 2016 |
| S B Components (International) Limited | Manufacturing | 1999 |
| S Clarke Traffic Consultants Limited | Construction | 2023 |
| S Curson and Sons Limited | Construction | 2010 |
| S E King Building Contractors Limited | Construction | 2000 |
| S E T Holdings Ltd | Real estate | 2018 |
| S H Commercial Body Repairs Limited | Wholesale & retail | 2023 |
| S H Everitt Limited | Construction | 2006 |
| S H Road Services Limited | Construction | 2025 |
| S Moat Fabrications Ltd | Manufacturing | 2024 |
| S N P Management Limited | Wholesale & retail | 2020 |
| S N P Sales Limited | Wholesale & retail | 2003 |
| S Pacey Plastering Ltd | Construction | 2024 |
| S R Ward Limited | Agriculture & fishing | 2003 |
| S&L Bespoke Ltd | Manufacturing | 2025 |
| S.B. Autocare (Wboro) Ltd | Wholesale & retail | 2009 |
| S.C.Law Limited | Information & communication | 2011 |
| S.E.H. Properties Limited | Real estate | 2018 |
| S.J. Medlock (Builders) Limited | Construction | 2002 |
| S3S IT Ltd | Information & communication | 2013 |
| Saap Retail Ltd | Wholesale & retail | 2022 |
| Sabrosa Properties Limited | Professional & scientific | 2013 |
| Sadamson Bookkeeping Ltd | Professional & scientific | 2024 |
| Safe Hands Care Services Ltd | Health & social care | 2022 |
| Safety & Training Consultancy Limited | Professional & scientific | 2008 |
| Safety Focus Services Ltd | Professional & scientific | 2020 |
| SAM Roberts Wedding Hair Specialist Limited | Other services | 2006 |
| Samfira Services Ltd | Administrative & support | 2017 |
| SAN Giovanni Restaurant Limited | Hospitality | 2015 |
| Sandisiwe Moyo Limited | Health & social care | 2023 |
| Sandy Limerick Dental Implants Limited | Health & social care | 2020 |
| Santhiran Ltd | Wholesale & retail | 2025 |
| Sanvita Ltd | Transport & logistics | 2026 |
| Sarah's Flowers and Gifts Ltd | Wholesale & retail | 2019 |
| Saulenas Driver Ltd | Transport & logistics | 2025 |
| Savage & Lyons LLP | | 2026 |
| Saver Market Ltd | Wholesale & retail | 2015 |
| Sayer Holding Company Limited | Financial services | 2023 |
| SB Recycling Limited | Water & waste | 2014 |
| SBS Homes Limited | Construction | 2021 |
| Scaffco Ltd | Construction | 2025 |
| Scarlynn Homes Limited | Real estate | 2020 |
| SCS Trophies Limited | Manufacturing | 2024 |
| SD Transportation Services Ltd | Transport & logistics | 2026 |
| Sdadamson Limited | Information & communication | 2024 |
| SDM Safety Netting & Scaffold Limited | Construction | 2022 |
| Sea View Group Limited | Hospitality | 2020 |
| Sebi Move Ltd | Transport & logistics | 2026 |
| Secret Garden Leisure Limited | Hospitality | 2023 |
| Secta Leagues Limited | Arts & recreation | 2019 |
| Seger's Limited | Professional & scientific | 2022 |
| SEK Dale Ltd | Agriculture & fishing | 2019 |
| Selfcair UK Limited | Transport & logistics | 2015 |
| Sensibletech Ltd | Information & communication | 2020 |
| Seriema UK Limited | Wholesale & retail | 2026 |
| Sexy Beef Ltd | Agriculture & fishing | 2025 |
| Sfmm Ltd | Hospitality | 2023 |
| SG Living Ltd | Wholesale & retail | 2023 |
| SGO Premedia Limited | Manufacturing | 2021 |
| Shadowcast Developments Limited | Manufacturing | 1981 |
| Shahada Nutrition Limited | Extraterritorial | 2025 |
| Shamrocks Builders Limited | Construction | 2019 |
| Shan Engineering Surveyors Limited | Construction | 2022 |
| Shannon Marston Trends Limited | Wholesale & retail | 2025 |
| Shapers Gym Limited | Arts & recreation | 2011 |
| Shapla Wisbech Ltd | Hospitality | 2024 |
| Shareacall Limited | Administrative & support | 2025 |
| Sheepbridge Mobile Home Park LLP | | 2015 |
| Sheila Tiller Limited | Wholesale & retail | 2014 |
| Shensons Properties Ltd | Construction | 2022 |
| Sherriff Consultancy Limited | Information & communication | 2025 |
| Shirley Wools Limited | Wholesale & retail | 2013 |
| SHM Estates Limited | Financial services | 2020 |
| Short Connections Ltd | Manufacturing | 2008 |
| Shqrb Limited | Agriculture & fishing | 2015 |
| Shrubland Estates Limited | Real estate | 2021 |
| Shur-Co Holdings Limited | Wholesale & retail | 2022 |
| Shur-Co UK Limited | Wholesale & retail | 2012 |
| SI Beauty Studio Ltd | Other services | 2026 |
| Side Streame Ltd | Real estate | 2023 |
| Sign and Drive Autos Ltd | Wholesale & retail | 2023 |
| Sigula Ltd | Transport & logistics | 2022 |
| Silverbranch Marketing Limited | | 1983 |
| Simon Allington Maintenance Limited | Other services | 2016 |
| Simon Allington Properties Limited | Real estate | 2015 |
| Simon Brown Formwork Limited | Construction | 2015 |
| Simple Goodbyes Limited | Other services | 2025 |
| Sims Holdings Ltd | Financial services | 2023 |
| Sirius Scaffolding Ltd | Construction | 2019 |
| Sisson Carpentry Ltd | Manufacturing | 2025 |
| Sitting Pretty Dressage Limited | Arts & recreation | 2011 |
| SIX Asset Group Ltd | Construction | 2026 |
| SIX Asset Rental Group Ltd | Hospitality | 2026 |