| Salescraft Limited | Professional & scientific | 2017 |
| Salkeld Limited | Financial services | 2017 |
| SAM Brabham Racing Limited | Arts & recreation | 2008 |
| SAM Cairns Associates Limited | Education | 2013 |
| Sama Systems Ltd | Information & communication | 2026 |
| Samantha Crane Limited | Information & communication | 2017 |
| Sams Entertainment Ltd | Hospitality | 2024 |
| Sanchez Ltd | Information & communication | 2019 |
| Sanday Brickwork Limited | Construction | 2018 |
| Sandbanks Yacht Company Limited | Manufacturing | 2012 |
| Sanders-Rhodes Ltd | Real estate | 2023 |
| Sandon Gauvain Limited | Professional & scientific | 2018 |
| Sandpiper Court Management Limited | Households | 1986 |
| Sanjsam Limited | Professional & scientific | 2003 |
| Santa the Explorer Ltd | Information & communication | 2025 |
| Santek Trustees Limited | Extraterritorial | 2012 |
| Saoirse Chun Cónaí Ltd | Professional & scientific | 2023 |
| Sargam Holdings Limited | Financial services | 2022 |
| Sargents Butchers Limited | Wholesale & retail | 2006 |
| SAS People and Wellbeing Ltd | Professional & scientific | 2026 |
| Sash Jayasinghe Limited | Education | 2025 |
| Sassy Smiles Ltd | Health & social care | 2022 |
| Saston Ltd. | Professional & scientific | 2002 |
| Satobe Limited | Real estate | 2023 |
| Saturn Scaffolding Ltd | Construction | 2024 |
| Sawley Cross Leisure Limited | Real estate | 1999 |
| Sawley Cross Properties Limited | Real estate | 1997 |
| Saxlund International Limited | Construction | 1998 |
| Saxon Eleven Ltd | Hospitality | 2025 |
| Saxon Gate FC Ltd | Hospitality | 2019 |
| Sbdl Education Limited | Education | 2020 |
| SBI TAC Pro Limited | Wholesale & retail | 2013 |
| SC Asbestos Ltd | Water & waste | 2018 |
| SC Tax Advisers and Accountants Limited | Professional & scientific | 2021 |
| Scale Surge Limited | Information & communication | 2026 |
| Scale With Limited | Wholesale & retail | 2026 |
| Scaliscro Estates Limited | Administrative & support | 2018 |
| Scalp Craft Ltd | Other services | 2025 |
| Scandinavian Carpentry Services Ltd | Manufacturing | 2017 |
| Scanish Ltd | Real estate | 2016 |
| Scanlan Interiors Ltd | Construction | 2022 |
| Scbr Management Limited | Real estate | 1973 |
| Sccr MED Dent Limited | Health & social care | 2025 |
| Scenara Limited | Administrative & support | 2020 |
| Scene Stealers Ltd | Professional & scientific | 2025 |
| Scenterbarks Ltd | Other services | 2016 |
| School of Creative Wellness Ltd | Health & social care | 2022 |
| Scientific Instrument Centre Limited(The) | Manufacturing | 1947 |
| Sclzk Limited | Extraterritorial | 2012 |
| Scmc Global Ltd | Other services | 2022 |
| Scootuk Ltd | Wholesale & retail | 2011 |
| Scorpion Motorcycles UK Ltd | Wholesale & retail | 2025 |
| Scott Healey Group Limited | Financial services | 2018 |
| Scott Healey Investments Limited | Financial services | 2017 |
| SDB Learning & Development Ltd | Professional & scientific | 2019 |
| Sdmiller Ltd | Construction | 2024 |
| SE Yachts Limited | Wholesale & retail | 1983 |
| Sea Bright Operations (UK) Ltd | Hospitality | 2023 |
| Seabreeze Creative Ltd | Professional & scientific | 2017 |
| Seafront Motors Limited | Wholesale & retail | 2022 |
| Seager and Hughes Limited | Real estate | 1995 |
| Seaholm Limited | Hospitality | 2026 |
| Seal Motor Company Ltd | Wholesale & retail | 2026 |
| Sealton Ltd | Wholesale & retail | 2016 |
| Sean Pruen Limited | Arts & recreation | 2019 |
| Searle & Taylor Holdings Limited | Financial services | 2013 |
| Searle & Taylor Limited | Wholesale & retail | 1998 |
| Seawing (Europe) Limited | Manufacturing | 1998 |
| SEC Consultants Limited | Financial services | 2017 |
| Seckford Homes Ltd | Real estate | 2013 |
| Second Spaces Limited | Real estate | 2023 |
| SECTOR13 Limited | Professional & scientific | 2016 |
| Secure Choice Advice Limited | Financial services | 2024 |
| Secure Port Technology Limited | Administrative & support | 2021 |
| Security & Vetting Solutions Limited | Administrative & support | 2005 |
| Segames Ltd | Information & communication | 2008 |
| SEJ Limited | Professional & scientific | 2017 |
| Sekhem Capital Limited | Financial services | 2025 |
| Selections International Ltd | Wholesale & retail | 2019 |
| Selective Media Limited | Professional & scientific | 2008 |
| Selenium Solar Solutions Ltd | Construction | 2025 |
| Seligman Farm Development Ltd | Agriculture & fishing | 2016 |
| Selway Joyce Group Ltd | Financial services | 2022 |
| Selwayjoyce Limited | Professional & scientific | 2011 |
| Semita Research Limited | Administrative & support | 2006 |
| Semtek Associates Limited | Real estate | 1970 |
| Seneca Group Ltd | Professional & scientific | 2017 |
| Sensaspectra Limited | Professional & scientific | 2026 |
| Sensatolla Limited | Health & social care | 2022 |
| Sensatolla Medical Limited | Health & social care | 2025 |
| Sensus Limited | Professional & scientific | 2026 |
| Sensus Therapy Ltd | Health & social care | 2021 |
| Serenity Living Care Group Limited | Administrative & support | 2025 |
| Sergeant Investment Management Limited | Real estate | 2023 |
| Sergio Cook for YOU Ltd | Hospitality | 2018 |
| Seru Coffee Ltd | Wholesale & retail | 2025 |
| Serverdock Ltd. | Information & communication | 2018 |
| SES Environmental Limited | Administrative & support | 2013 |
| Setsuits Ltd | Professional & scientific | 2021 |
| Setters and Specialists Ltd | Extraterritorial | 2020 |