| Spendio Limited | Professional & scientific | 2023 |
| Spenspeed Engineering Limited | Information & communication | 2022 |
| SPF Management Consultants Limited | Professional & scientific | 2021 |
| Spike Engineering Limited | Professional & scientific | 2021 |
| Spiral UP! Limited | Professional & scientific | 2025 |
| Spirerite Limited | Households | 1986 |
| Spirit Trails Limited | Administrative & support | 1998 |
| Spiteri & Sons Limited | Construction | 2024 |
| Splash Management Consultancy Limited | Professional & scientific | 1999 |
| Spoqe UK Ltd | Information & communication | 2026 |
| Spotless Properties Ltd | Administrative & support | 2025 |
| Sprig Advisory Limited | Professional & scientific | 2025 |
| Spriglees Ltd | Information & communication | 2023 |
| Springdale Holdings Ltd | Financial services | 2019 |
| Springdale Property Limited | Real estate | 2019 |
| Springhill House Management Limited | Households | 1999 |
| Springvale Hill Limited | Health & social care | 2023 |
| Springwater Consulting Ltd | Information & communication | 2017 |
| Sprint Professional Services Ltd | Information & communication | 2022 |
| SPS Martin Holdings Limited | Administrative & support | 1968 |
| Spur Close Freehold Limited | Households | 2002 |
| Spurdy Project Services Limited | Information & communication | 2010 |
| Spuron Ltd | Information & communication | 2012 |
| SPW Solutions Limited | Information & communication | 2008 |
| Sqft Limited | Real estate | 2013 |
| SQL Engine Ltd | Information & communication | 2018 |
| Square Cube Limited | Information & communication | 2006 |
| Square One Gym Holdings Ltd | Real estate | 2025 |
| Square One Gym Ltd | Arts & recreation | 2021 |
| Squeaky Clean Window Cleaners Limited | Administrative & support | 2017 |
| Squirrel Consultants Limited | Information & communication | 2023 |
| SRC Lettings Limited | Real estate | 2025 |
| SRD Advisory Limited | Professional & scientific | 2023 |
| SRI Management Ltd | Professional & scientific | 2013 |
| SRM Consultancy Associates Ltd | Administrative & support | 2009 |
| SRP Mechanical & Building Solutions Ltd | Construction | 2024 |
| SRQ Engineering Limited | Professional & scientific | 2024 |
| SS4A Limited | Information & communication | 2024 |
| Ssds Consultancy Ltd | Professional & scientific | 2025 |
| Ssjp Services Limited | Construction | 2017 |
| SSL Conversions Limited | Manufacturing | 2019 |
| Ssol Limited | Information & communication | 2024 |
| Sswda Limited | Other services | 2026 |
| ST Anne's Court Care Limited | Health & social care | 2012 |
| ST Giles Farms Limited | Agriculture & fishing | 1961 |
| ST Margarets Homecare Limited | Health & social care | 2022 |
| ST. Andrew Chiropractic Clinic Limited | Health & social care | 2019 |
| ST. Antony's (Bournemouth) Maintenance Co. Limited | Households | 1970 |
| ST. Catherines Court (Wimborne) Freehold and Maintenance Limited | Households | 1979 |
| ST. James's Teas Limited | Manufacturing | 2010 |
| ST. Moritz Court Limited | Households | 1978 |
| Stackshark Ltd | Information & communication | 2020 |
| Stak Orthopaedics Ltd | Health & social care | 2020 |
| Stakz Limited | Real estate | 2015 |
| Stalactis Consulting Limited | Professional & scientific | 2026 |
| Stanbridge Motors Limited | Wholesale & retail | 2000 |
| Stanley's Catering Ltd | Hospitality | 2021 |
| Stansted Consultants Limited | Information & communication | 2025 |
| Stapehill Futures Ltd | Professional & scientific | 2012 |
| Starbay Limited | Hospitality | 2014 |
| Starlit Havens Limited | Real estate | 2023 |
| Starplus Services Limited | Information & communication | 2011 |
| Starr Consultancy Ltd | Professional & scientific | 2014 |
| Starrokate Limited | Real estate | 1972 |
| Startek Systems Limited | Information & communication | 2011 |
| Stater Consulting Limited | Information & communication | 2022 |
| Statons Limited | Other services | 2007 |
| Staybreak Ltd | Hospitality | 2025 |
| Staying Safe UK Ltd | Professional & scientific | 2026 |
| Steadfast Consulting Services Ltd | Information & communication | 2025 |
| Steadfast Digital Consultancy Ltd | Information & communication | 2026 |
| Steam & Pressure Washer Services Limited | Manufacturing | 1983 |
| Steene Security Consulting Limited | Information & communication | 2024 |
| Stella Focus Consulting Limited | Administrative & support | 2021 |
| Stellar Coach Ltd | Professional & scientific | 2023 |
| Stemero Limited | Information & communication | 2020 |
| Stephen Foster IT Services Limited | Information & communication | 2025 |
| Stepsworth Ltd | Professional & scientific | 2022 |
| Sterling ARC Limited | Information & communication | 2022 |
| Sterling Estimation Ltd | Administrative & support | 2018 |
| Sterlingdale Ltd | Construction | 2015 |
| Steve Daniel Associates Limited | Professional & scientific | 2011 |
| Steve Gilbert Consultancy Ltd | Professional & scientific | 2013 |
| Steve Howard Building Contractors Limited | Construction | 2012 |
| Steve Noel Vehicle Engineers Limited | Wholesale & retail | 2014 |
| Steve Vaughan Contractors Limited | Other services | 2014 |
| Stevemarsh Youtube Limited | Information & communication | 2024 |
| Stevens Master Thatchers Ltd | Construction | 2019 |
| Stevenson Court Management Company Limited | Households | 1990 |
| Stewart Lodge Management Company Limited | Households | 2004 |
| STF Holdings Ltd | Financial services | 2017 |
| Stickland Estates Ltd | Real estate | 2025 |
| Sticks & Stones West ROW Management Company Limited | Households | 2024 |
| Still WE Rise Coaching Ltd | Education | 2019 |
| Stilwell Gray Limited | Extraterritorial | 2020 |
| Stirrup Group Limited | Other services | 2017 |
| Stokes Software Ltd | Information & communication | 2025 |
| Stokes Stoves Limited | Construction | 2025 |
| Stolen BMX Limited | Wholesale & retail | 2002 |
| Stolen Brand Ltd | Wholesale & retail | 2025 |