| Squarebox Commercial Ltd | Real estate | 2024 |
| Squarebox Property Ltd. | Real estate | 2018 |
| Squashcourtsupplies Limited | Wholesale & retail | 2024 |
| Srsuk Ltd | Construction | 2026 |
| SSC Cars Ltd | Transport & logistics | 2023 |
| SSH Finance Limited | Financial services | 2016 |
| SSH Property Investment Limited | Real estate | 2015 |
| SSH Recycling Limited | Manufacturing | 2018 |
| SSH Trading Limited | Water & waste | 2015 |
| SST Trading Limited | Real estate | 2013 |
| ST Andrew's Park (Aylestone) Management Company Limited | Households | 2021 |
| ST Apollina Dental Services Ltd | Health & social care | 2024 |
| ST Georges Fields (Wootton) Management Company Limited | Households | 2015 |
| ST Giles Gardens Management Company Limited | Households | 2012 |
| ST Hotel Management Ltd | Professional & scientific | 2016 |
| ST James Fields (Lostock Hall) Management Company Limited | Households | 2015 |
| ST James Park Limited | Financial services | 2019 |
| ST Johns (the Assembly) Ltd | Households | 2026 |
| ST Lawrence Green Management Company Limited | Households | 2018 |
| ST Lawrence's Fields (Management Company) Limited | Households | 2019 |
| ST Management Services LLP | | 2016 |
| ST Mary's Park (Penwortham) Management Company Limited | Households | 2018 |
| ST Mawes Estates Ltd | Real estate | 2019 |
| ST Medicolegal Limited | Health & social care | 2019 |
| ST Michael's Park (Upton) Management Company Limited | Households | 2020 |
| ST Virginia Healthcare Ltd | Health & social care | 2022 |
| ST. Mary's Grocery Ltd | Wholesale & retail | 2022 |
| ST. Teilo Family Care Ltd | Health & social care | 2023 |
| ST3PODS Ltd | Professional & scientific | 2024 |
| Standoverthere Limited | Arts & recreation | 2014 |
| Stanley Gardens (Management Company) Limited | Households | 2019 |
| Stanlow CRS Ltd. | Administrative & support | 2014 |
| Stanneylands Holdings Limited | Information & communication | 2021 |
| Stansfield Medical Ltd | Health & social care | 2025 |
| Star Labour Ltd | Administrative & support | 2026 |
| Star Sports & Entertainment Ltd | Arts & recreation | 2009 |
| Starfish 360 Ltd | Administrative & support | 2010 |
| Starmer Urology Ltd | Health & social care | 2023 |
| Startup Wingman Ltd | Information & communication | 2024 |
| Station Grange (Coventry) Management Company Limited | Households | 2025 |
| Stationery Supplies Wilmslow Limited | Wholesale & retail | 2020 |
| Stayclean Contract Services Limited | Administrative & support | 2000 |
| Steelit Limited | Extraterritorial | 2011 |
| Step by Step Surgery Ltd | Health & social care | 2021 |
| Stephen Black Vascular Limited | Health & social care | 2011 |
| Steppingstones Montessori Ltd | Education | 2025 |
| Sterling DE ZUK Divorce & Finance Specialist Limited | Professional & scientific | 2023 |
| Sterling Nexora Consultants Ltd | Administrative & support | 2026 |
| Sterling Sense Limited | Information & communication | 2025 |
| Sternlea Limited | Real estate | 1983 |
| Steven Finney Limited | Health & social care | 2023 |
| Stewart-Parry Joinery & Building Services Limited | Construction | 2021 |
| Stig'Shop (Wilmslow) Limited | Other services | 2015 |
| Stile END Developments Limited | Construction | 2026 |
| Stimpson Healthcare Limited | Health & social care | 2017 |
| Stitching Threadz Limited | Wholesale & retail | 2025 |
| Stocksurvey Limited | Professional & scientific | 2025 |
| Stok Facades Ltd | Construction | 2020 |
| Stoke Orthopaedic Solutions Ltd | Health & social care | 2022 |
| Stokhaus Limited | Real estate | 2015 |
| Stolen Lamb Ltd | Hospitality | 2024 |
| Stone Sure Limited | Health & social care | 2023 |
| Stonechester (Stoke) Limited | Real estate | 1998 |
| Storage (Accrington) Ltd | Real estate | 2022 |
| Storage (Alfreton) Ltd | Real estate | 2026 |
| Storage (Corby) Ltd | Real estate | 2025 |
| Storage (Lytham) Ltd | Real estate | 2023 |
| Storage (Manchester) Ltd | Real estate | 2023 |
| Storage (Newcastle) Ltd | Real estate | 2026 |
| Storage (Peterborough) Ltd | Real estate | 2023 |
| Storage (Stoke) Ltd | Real estate | 2023 |
| Storage (Tamworth) Ltd | Real estate | 2022 |
| Storage (Telford) Ltd | Real estate | 2021 |
| Storage (Worksop) Ltd | Households | 2022 |
| Storm Cars Ltd | Wholesale & retail | 2020 |
| Stormway Ltd | Hospitality | 2019 |
| Stormway Property Ltd | Households | 2023 |
| STP Capital Ltd | Energy | 2015 |
| Straightforward Consultancy Limited | Professional & scientific | 2009 |
| Strang Anaesthesia Limited | Health & social care | 2020 |
| Strangeways Beers & Spirits Limited | Wholesale & retail | 2024 |
| Stratagia Limited | Information & communication | 2002 |
| Stratapeople Limited | Professional & scientific | 2020 |
| Strategac Limited | Professional & scientific | 2020 |
| Strategic Controls Limited | Professional & scientific | 2015 |
| Strategic Global Consultants Limited | Education | 2016 |
| Street to Go Limited | Wholesale & retail | 2011 |
| Stretfordend Limited | Mining & quarrying | 2011 |
| Stridewell Care Ltd | Health & social care | 2022 |
| Stringfellows Civil Engineering Limited | Construction | 2022 |
| Stripe Colour Studio Ltd | Other services | 2021 |
| STRIPE47 Consulting Ltd | Professional & scientific | 2025 |
| Strive Supply Chain Services Ltd | Administrative & support | 2013 |
| Strolling NOT Scrolling Ltd | Arts & recreation | 2026 |
| Strong Flavours Limited | Hospitality | 2012 |
| Strongrok Divorce Finance Wealth Law Ltd | Professional & scientific | 2025 |
| Structura Recruitment Limited | Administrative & support | 2023 |
| Stuart Carter Ltd | Professional & scientific | 2025 |
| Stuart Henry Kitchens Limited | Manufacturing | 2007 |
| Stuart Medical and Legal Limited | Health & social care | 2018 |