| M D M Healthcare Ltd | Manufacturing | 2008 |
| M Debono Limited | Health & social care | 2013 |
| M G G Manchester Ltd | Other services | 1999 |
| M J Earley Ltd | Health & social care | 2018 |
| M J G Healthcare Limited | Health & social care | 2019 |
| M J Statham Limited | Real estate | 2022 |
| M Manisali Limited | Health & social care | 2013 |
| M Projects - Bath House Farm Care Ltd | Construction | 2024 |
| M Projects - Bath House Farm Housing Ltd | Construction | 2024 |
| M R Garnett Limited | Health & social care | 2018 |
| M R Hellbender Ltd | Information & communication | 2023 |
| M Rothwell Limited | Health & social care | 2014 |
| M S Butterworth Limited | Health & social care | 2010 |
| M S Wilson Surgical Services Ltd | Health & social care | 2015 |
| M Teft Limited | Health & social care | 2023 |
| M Teft Property Limited | Real estate | 2024 |
| M V a Holdings Limited | Financial services | 1999 |
| M White Film Services Limited | Information & communication | 2019 |
| M&D Building and Refurbishment Ltd | Construction | 2015 |
| M&J Recycling Limited | Wholesale & retail | 2026 |
| M&J Thai to Go Ltd | Hospitality | 2024 |
| M&J Walton Ltd | Health & social care | 2018 |
| M.A.X. Funding Limited | Financial services | 2013 |
| M.F.H Consulting Limited | Other services | 2015 |
| M.I.A Engineering Consultancy Limited | Professional & scientific | 2013 |
| M.T.Ludlow Painting and Decorating Contractors Ltd | Administrative & support | 2013 |
| M1 Nails Wilmslow Limited | Other services | 2024 |
| M999 Trading Ltd | Other services | 2025 |
| MA Optical Limited | Wholesale & retail | 2024 |
| MA Taylor Services Limited | Financial services | 2026 |
| Maab Properties Ltd | Real estate | 2024 |
| Maan Consulting LLP | | 2026 |
| MAC Anaesthesia Limited | Health & social care | 2022 |
| MAC ENG Services Ltd | Professional & scientific | 2026 |
| Macclesfield Orthopaedic Group LLP | | 2025 |
| Mack Kitchens & Carpentry Ltd | Construction | 2025 |
| Mackenzie Campbell Ltd | Health & social care | 2026 |
| Mackenzie Marketing Limited | Other services | 2010 |
| Macula Care Limited | Health & social care | 2019 |
| Madevo Limited | Information & communication | 2022 |
| Madiba II Enterprises Ltd | Professional & scientific | 2025 |
| Madras HUT Limited | Hospitality | 2021 |
| Magentic Ltd | Other services | 2014 |
| Magnasurg Investments and Trading Ltd | Financial services | 2021 |
| Maiden Studio Ltd | Professional & scientific | 2025 |
| Maidstone Healthcare Ltd | Professional & scientific | 2021 |
| Mains Electrical Installations Limited | Construction | 2014 |
| Maintainx Ltd | Construction | 2023 |
| Mair Consulting Ltd | Professional & scientific | 2011 |
| Majority Hens Ltd | Health & social care | 2020 |
| Make Events Limited | Other services | 2015 |
| Make Your Mark MCR Limited | Professional & scientific | 2024 |
| Making Consulting Ltd | Real estate | 2023 |
| Making Properties Limited | Real estate | 2022 |
| Malhotra Foot and Ankle Limited | Health & social care | 2020 |
| Mallinson's of Wilmslow Limited | Construction | 2025 |
| Mallucci Liverpool Limited | Health & social care | 2019 |
| Manage Pain Ltd | Hospitality | 2014 |
| Managed and Delivered Limited | Professional & scientific | 2025 |
| Managed Travel Ltd | Other services | 2013 |
| Managing Spaces Limited | Construction | 2018 |
| Manchester and Metropolitan Real Estate Advisory Limited | Professional & scientific | 2025 |
| Manchester ARM Clinic Limited | Health & social care | 2011 |
| Manchester Chest Clinic Ltd | Health & social care | 2025 |
| Manchester Dermatopathology Service Solutions Limited | Health & social care | 2019 |
| Manchester EAR, Nose and Throat Oncology Recovery Support Community Interest Company | Health & social care | 2023 |
| Manchester Eco Home Ltd | Construction | 2023 |
| Manchester ENT Specialist Limited | Health & social care | 2017 |
| Manchester Events Management Ltd | Professional & scientific | 2024 |
| Manchester Facilities Management Limited | Administrative & support | 2020 |
| Manchester Kitchen Limited | Hospitality | 2025 |
| Manchester Knees Ltd | Health & social care | 2018 |
| Manchester Medicolegal Limited | Health & social care | 2022 |
| Manchester Neurophysiology Ltd | Health & social care | 2026 |
| Manchester Neurosurgery Limited | Health & social care | 2011 |
| Manchester Paediatric Consultancy Ltd | Professional & scientific | 2025 |
| Manchester Rentals Limited | Real estate | 2002 |
| Manchester Sports Massage Ltd | Arts & recreation | 2022 |
| Manchester Trading Limited | Wholesale & retail | 2015 |
| Manchester Triathlon Club | Arts & recreation | 2018 |
| Manchester Vascular Services Limited | Health & social care | 2013 |
| Mancunium Business Advisors Limited | Wholesale & retail | 2025 |
| Manenergy Associates Limited | Professional & scientific | 2016 |
| Mango Tree Distributions Ltd | Wholesale & retail | 2011 |
| Manjunath Medical Limited | Health & social care | 2023 |
| Manlaw Property Limited | Real estate | 2020 |
| Manor Point (Holmes Chapel) Holdings Limited | Administrative & support | 2019 |
| Manor Point (Holmes Chapel) Limited | Construction | 2019 |
| Mansell Consulting Group Ltd | Administrative & support | 2022 |
| Mansfield Hair Products Limited | Other services | 2021 |
| Mantis Energy Ltd | Wholesale & retail | 2018 |
| Mantis Group Ltd | Financial services | 2024 |
| Mantis Projects Ltd | Construction | 2020 |
| Mantis Property Ltd | Real estate | 2022 |
| Maparc Ltd | Construction | 2021 |
| Maple and Chestnut Limited | Households | 2006 |
| Maple Leaf Developments Limited | Extraterritorial | 1998 |
| Marguerite Patisserie Ltd | Manufacturing | 2025 |
| Maria's With Love Ltd | Manufacturing | 2018 |
| Maribou Ltd | Health & social care | 2022 |