| Sell My Wedding Limited | Information & communication | 2013 |
| Sensible Heating Solutions Limited | Construction | 2017 |
| Sercrest Ltd | Construction | 2024 |
| SF Property Renovations Ltd | Construction | 2026 |
| SFL Leicester Glass Ltd | Other services | 2020 |
| SGK Builders Ltd | Construction | 2025 |
| Shabba Stevo Ltd | Wholesale & retail | 2022 |
| Shadow Rise Investments Limited | Real estate | 2014 |
| Shah Clinical Services Ltd | Health & social care | 2024 |
| Shahraiz Retail Limited | Wholesale & retail | 2025 |
| Shanj Properties Leicester Limited | Real estate | 2024 |
| Shanj Properties LLP | | 2022 |
| Sharifbot Limited | Information & communication | 2026 |
| Sharma Enterprise London Limited | Wholesale & retail | 2021 |
| Shelbro Ltd | Wholesale & retail | 2017 |
| Shenoz Properties Ltd | Real estate | 2019 |
| Shepherdhunters Limited | Transport & logistics | 2026 |
| Shibobs Ltd | Real estate | 2016 |
| Shire Lifestyles Ltd | Real estate | 2013 |
| Shiv Property Sourcing Ltd | Construction | 2025 |
| Shooters Range Holdings Ltd | Financial services | 2026 |
| Shooters Range Nottingham Ltd | Arts & recreation | 2025 |
| Shooters Range Sheffield Ltd | Arts & recreation | 2026 |
| Shubh Construction Ltd | Construction | 2026 |
| Siddhi Reiki and Yoga Ltd | Health & social care | 2024 |
| Signaturespace Realty Ltd | Real estate | 2024 |
| Simeng Holdings Ltd | Real estate | 2020 |
| Simlar Energy & OIL Facilitation Ltd | Wholesale & retail | 2025 |
| Simlar Ltd | Education | 2023 |
| Simlar Properties Ltd | Real estate | 2024 |
| Simple Text Solutions Limited | Real estate | 1993 |
| Simplify Structures Ltd | Professional & scientific | 2023 |
| Simplify Structures Reports Ltd | Professional & scientific | 2025 |
| SIX Spa Ltd | Health & social care | 2024 |
| SJC Entertainment Ltd | Hospitality | 2026 |
| SK Filson Limited | Wholesale & retail | 2015 |
| SK Gifts Ltd | Other services | 2023 |
| SK Painting & Decorating Ltd | Construction | 2024 |
| Skillman Healthcare Ltd | Administrative & support | 2022 |
| Skokan Ltd | Transport & logistics | 2014 |
| Sky High Travels 2023 Limited | Administrative & support | 2023 |
| Sky Online Trading Ltd | Wholesale & retail | 2021 |
| Skyline Builds Ltd | Construction | 2024 |
| Slick Removals MAN and Van Leicester Shire Ltd | Water & waste | 2017 |
| Smart Hire Car Ltd | Administrative & support | 2025 |
| Smart Trade Centre Ltd | Wholesale & retail | 2020 |
| Smartoffer Homes Ltd | Real estate | 2026 |
| SME Painting & Decorating Ltd | Construction | 2025 |
| SMS Engineering Solutions Limited | Professional & scientific | 2016 |
| SNB Flooring Ltd | Wholesale & retail | 2021 |
| Sohal Properties Leicester Ltd | Real estate | 2025 |
| Sokare Ltd | Wholesale & retail | 2025 |
| Solanki Healthcare Limited | Wholesale & retail | 2021 |
| Solicitor Estate Agents Legal Services Limited | Extraterritorial | 1998 |
| Solid State UK Events and Furniture Hire Limited | Administrative & support | 2018 |
| Sonal Enterprises (Textiles) Limited | Information & communication | 1976 |
| Sonwasca Tours Limited | Transport & logistics | 2026 |
| Sopa Therapy Limited | Other services | 2018 |
| Sophena Properties Ltd | Real estate | 2022 |
| Sophia Hair Studio Limited | Other services | 2019 |
| Soulphotography Studios Limited | Professional & scientific | 2017 |
| Sound Construction Group Ltd | Professional & scientific | 2019 |
| Sound Property Lettings Ltd | Real estate | 2026 |
| Sourcing International Limited | Manufacturing | 2020 |
| South Leicester Teaching Practices Ltd | Education | 2014 |
| Spaghetti Pubs Ltd | Hospitality | 2025 |
| Spar Hackenthorpe Ltd | Wholesale & retail | 2015 |
| Sparkleklin Cleaning Services Limited | Administrative & support | 2025 |
| Sparkys Specialist Limited | Construction | 2016 |
| Spee Dental Care Ltd | Health & social care | 2022 |
| Spellbound Marketing Ltd | Wholesale & retail | 2020 |
| Sphn&M Limited | Wholesale & retail | 2012 |
| Sporanka Ltd | Wholesale & retail | 2022 |
| Spot & SEW Limited | Real estate | 2019 |
| Spot on Building Contractors Ltd | Construction | 2017 |
| Spraying Works Ltd | Manufacturing | 2021 |
| SR1 Leicester Ltd | Arts & recreation | 2024 |
| SRP Landscapes Limited | Administrative & support | 2003 |
| SS Dream Homes Ltd | Real estate | 2023 |
| Ssaf Trading Ltd | Hospitality | 2025 |
| Stage Taxis Limited | Transport & logistics | 2019 |
| Staged Spaces Limited | Professional & scientific | 2024 |
| Stainbock Limited | Transport & logistics | 2024 |
| Staner UK Ltd | Information & communication | 2025 |
| Star Beauty & Cosmetics Ltd | Other services | 2026 |
| Stats FC Limited | Information & communication | 2015 |
| Stbas Leicester Ltd | Professional & scientific | 2019 |
| Stella Beauty Salon Ltd | Health & social care | 2026 |
| Stitch & Print Studio Ltd | Manufacturing | 2026 |
| Stockdale Harrison Estates Ltd | Real estate | 2026 |
| Stokes Removals and Storage Limited | Transport & logistics | 2013 |
| Stokes Removals Limited | Transport & logistics | 2014 |
| Stonesby House Ltd | Health & social care | 2008 |
| Stop N Shop Leicester Ltd | Wholesale & retail | 2024 |
| Streamline Cargo Limited | Transport & logistics | 2025 |
| Stretton Oak Limited | Wholesale & retail | 2018 |
| Studio Spmu Ltd | Other services | 2026 |
| Stunna's Caribbean Flavours Ltd | Hospitality | 2025 |
| Styloid Properties Limited | Real estate | 2017 |
| SUB Mains UK Ltd | Construction | 2022 |