| Elliott Milburn Electrical Limited | Construction | 2018 |
| Elliott Projects (Consultancy) Limited | Construction | 2019 |
| Elliotts Landscaping and Gardening Supplies Limited | Administrative & support | 2024 |
| Ellis Dickinson Ltd | Professional & scientific | 2023 |
| Elmtree Gardens NE Ltd | Construction | 2013 |
| Elsie’S Place Ltd | Hospitality | 2024 |
| Elysian Aesthetics Whitley Bay Ltd | Other services | 2025 |
| Embedded UN Limited | Extraterritorial | 2023 |
| Embleton England Limited | Professional & scientific | 2018 |
| Embleton Hall Ltd | Construction | 2021 |
| Embleys Estate Agents (North East) Ltd | Real estate | 2014 |
| Emejohn Ltd | Hospitality | 2023 |
| Emerald Legal Services Limited | Professional & scientific | 2017 |
| Eminwise Ltd | Wholesale & retail | 2024 |
| Emmalli Hair and Beauty Limited | Other services | 2021 |
| Empress Property Investment Ltd | Real estate | 2024 |
| Endeavour Developments Limited | Construction | 2009 |
| Endeavour Lettings Limited | Construction | 2006 |
| Endeavour Living Ltd | Real estate | 2020 |
| Endeavour Property (Holdings) Limited | Construction | 2013 |
| Endpay Ltd | Administrative & support | 2025 |
| Enjik Limited | Administrative & support | 2001 |
| Enlightened Media Solutions Limited | Information & communication | 2011 |
| Enterprise Safari Limited | Education | 2014 |
| Entropy Holdings Limited | Professional & scientific | 2026 |
| Eprr Ltd | Other services | 2011 |
| Erbl Management Ltd | Hospitality | 2023 |
| Ergo Flex International Limited | Wholesale & retail | 2022 |
| Ergo Flex Limited | Wholesale & retail | 2007 |
| Erin Gray Limited | Information & communication | 2017 |
| Erinoid Ltd | Extraterritorial | 2014 |
| Errington Estates Ltd | Real estate | 2021 |
| Erskine Court (Lindisfarne Park, Newcastle Upon Tyne) Residents Association Limited | Real estate | 1981 |
| Esam Khass Property Holdings Ltd | Real estate | 2020 |
| ESD Electrical Services Ltd | Construction | 2022 |
| Esdc Property Ltd | Real estate | 2022 |
| Espley 6 Ltd | Real estate | 2024 |
| Esquire Barber Limited | Other services | 2001 |
| Essay Limited | Real estate | 2020 |
| Estate Homes LLP | | 2015 |
| Etal Court Maintenance Limited | Households | 1969 |
| Etal House Management Company Limited | Households | 1991 |
| Ethical Energy Consultants Ltd | Professional & scientific | 2019 |
| Etica (Global) Ltd | Education | 2021 |
| Evan's Catering Limited | Hospitality | 2016 |
| Eventcover Education Limited | Education | 2006 |
| Executive Chariots Limited | Administrative & support | 2019 |
| Exploring, ETC Limited | Education | 2021 |
| EXT Software Services Ltd | Professional & scientific | 2022 |
| Eyeworks Optical Limited | Health & social care | 2015 |
| F. E. Laughlin Limited | Professional & scientific | 2007 |
| F.& R.Belbin Limited | Manufacturing | 1961 |
| Face Facts Aesthetics Ltd | Health & social care | 2016 |
| Face Masc Limited | Wholesale & retail | 2020 |
| Fairway Finder Ltd | Arts & recreation | 2024 |
| Falcon Scientific Limited | Professional & scientific | 2011 |
| Family Leisure Limited | Arts & recreation | 2018 |
| Fantastic Holdings Ltd | Financial services | 2023 |
| Farplace Animal Rescue Limited | Other services | 2002 |
| Fast Flow Plumbing & Heating Ltd | Construction | 2016 |
| FAT Butcher Bar and Grill Limited | Hospitality | 2025 |
| Feathermemorialcastingsne Ltd | Arts & recreation | 2025 |
| Feda Architects Ltd | Professional & scientific | 2020 |
| Fellows Property Ltd | Real estate | 2017 |
| Ferndene Residents Association Limited | Households | 2000 |
| Ferns & Pearls Ltd | Hospitality | 2025 |
| Fernwood Residents Association Limited | Households | 1989 |
| Ferryboat Media Limited | Information & communication | 2022 |
| FES Joinery Services Ltd | Construction | 2026 |
| FHK Collectables Ltd | Wholesale & retail | 2025 |
| Ficare 360 Ltd | Education | 2025 |
| Fifty Plus Longevity Ltd | Health & social care | 2024 |
| Filament Creative Studio Limited | Arts & recreation | 2025 |
| Finance With Faye Ltd | Professional & scientific | 2026 |
| Finch Salon Ltd | Other services | 2020 |
| Findlays Access and Coatings Limited | Professional & scientific | 2019 |
| Fine Homes North East Limited | Construction | 2024 |
| Finlay Maritime Consultancy Ltd | Professional & scientific | 2022 |
| Finney Scientific Consulting Limited | Professional & scientific | 2022 |
| Finnie Scientific Ltd | Professional & scientific | 2024 |
| First Blood Group Ltd | Professional & scientific | 2025 |
| First Class Permanent Recruitment Ltd | Administrative & support | 2016 |
| First Class Production Audio Limited | Information & communication | 2016 |
| First Class Properties NE Limited | Real estate | 2021 |
| Fitzpatrick Lettings Limited | Extraterritorial | 2018 |
| Flash Tackle Ltd | Wholesale & retail | 2018 |
| Fleetwood FRP Limited | Construction | 2004 |
| Fleming Private Office Ltd | Professional & scientific | 2014 |
| Fleur Couture Florists Limited | Wholesale & retail | 2017 |
| Flip Design & Marketing Ltd | Other services | 2023 |
| Flockworks Ltd | Extraterritorial | 2012 |
| Floorcare Group Ltd | Administrative & support | 2026 |
| Floyd Technical Services Ltd | Arts & recreation | 2014 |
| Fluffy Godmother Limited | Professional & scientific | 2011 |
| Flyingfish Design Consultants Limited | Professional & scientific | 1997 |
| Focus Architecture and Surveying Limited | Professional & scientific | 2018 |
| Foodies for ALL CIC | Education | 2026 |
| FOR the Love of the North Ltd | Wholesale & retail | 2019 |
| Ford Accommodation Limited | Hospitality | 2023 |
| Ford Psychological Services Ltd | Health & social care | 2020 |