| MR Strategic Thinking Ltd | Professional & scientific | 2024 |
| MRK Waste Disposal Ltd | Water & waste | 2026 |
| MS Barber (NE25) Limited | Other services | 2023 |
| Msgw Ltd | Hospitality | 2019 |
| Mtap Ltd | Households | 2025 |
| Muka Caffe Limited | Hospitality | 2024 |
| Mulvtech Ltd | Information & communication | 2015 |
| Museumnext Ltd | Administrative & support | 2015 |
| Musgrove Services Ltd | Administrative & support | 2025 |
| Mvsg Ltd | Real estate | 2024 |
| MW Catering Services Ltd | Hospitality | 2016 |
| MW Power GEN Services Ltd | Manufacturing | 2014 |
| Mwwassociates Ltd | Professional & scientific | 2018 |
| My Car Sales Ltd | Wholesale & retail | 2024 |
| My Core GUY Ltd | Wholesale & retail | 2020 |
| My Energy Pro Limited | Construction | 2026 |
| Mybk Ltd | Wholesale & retail | 2019 |
| Mytub Ltd | Administrative & support | 2007 |
| Myway Developments Limited | Real estate | 1999 |
| Mywinningbuddy Ltd | Other services | 2025 |
| N Bingham Consulting Ltd | Administrative & support | 2013 |
| N Glaziers Ltd | Other services | 2018 |
| N T Garden Services Ltd | Administrative & support | 2023 |
| N&K (NE) Ltd | Hospitality | 2026 |
| N.B. Macgregor & SON Contractors Ltd | Water & waste | 2008 |
| Nationwide Audio Visual Limited | Construction | 2014 |
| Nazareth Ltd | Hospitality | 2018 |
| Nd-Understood Ltd | Health & social care | 2022 |
| NE Facilities Management Ltd | Construction | 2026 |
| NE Lets Limited | Real estate | 2019 |
| NE Marine Survey Services Limited | Professional & scientific | 2017 |
| NE Online Flooring Ltd | Wholesale & retail | 2020 |
| NE Property Holdings Limited | Real estate | 2021 |
| NE Refurbishment Specialists Ltd | Construction | 2024 |
| NE Safety Group Limited | Hospitality | 2019 |
| NE Solopreneurs Ltd | Administrative & support | 2025 |
| NE1'S Mental Health CIC | Health & social care | 2025 |
| Nearby Eastcoast Taxis Ltd | Transport & logistics | 1998 |
| Neasdon Quality Inspection Services Limited | Professional & scientific | 2015 |
| Need Music Ltd | Arts & recreation | 2012 |
| Neil Barker Associates Limited | Professional & scientific | 2012 |
| Neilson Duncan Lettings Ltd | Real estate | 2021 |
| Nelson Properties (Newcastle) Limited | Administrative & support | 2017 |
| Nepcs Ltd | Wholesale & retail | 2014 |
| Nepenthe Limited | Wholesale & retail | 2014 |
| Nesbitt Technology Services Ltd | Information & communication | 2020 |
| Neuexpert Limited | Health & social care | 2026 |
| Neuro-Insight (UK) Limited | Professional & scientific | 2010 |
| Neuroinclusive Education (Holdings) Limited | Financial services | 2025 |
| Neuroinclusive Education (PC) Limited | Manufacturing | 2025 |
| Neuroinclusive Education Ltd | Manufacturing | 2023 |
| New Claremont Ltd | Hospitality | 2023 |
| New Hartley Community Services Limited | Wholesale & retail | 2017 |
| New Hartley SMC Ltd | Hospitality | 2026 |
| New Sydco Ltd | Hospitality | 2018 |
| New Telogix Energy and Solutions Ltd | Information & communication | 2025 |
| Newcastle City Apartment Limited | Households | 2022 |
| Newford Engineering Limited | Other services | 2002 |
| Newgate Property Investments Ltd | Real estate | 2023 |
| Newings Lettings Ltd | Real estate | 2026 |
| Newspace Garage Conversions Ltd | Construction | 2026 |
| Newtons Coffee House Ltd | Hospitality | 2022 |
| Next Steps Tutoring and Send Consultancy Ltd | Education | 2025 |
| NEXT2BUY Limited | Real estate | 2003 |
| Ngon Banh MI Ltd | Hospitality | 2022 |
| NH Collection Ltd | Real estate | 2024 |
| Nicholsons Butchers (Whitley Bay) LLP | | 2020 |
| Nick Cotton Limited | Professional & scientific | 2025 |
| Nick Ingram Sound Ltd | Arts & recreation | 2014 |
| Nick Savage Ltd | Information & communication | 2023 |
| Nicol Homes Ltd | Real estate | 2020 |
| Nicole Dean Limited | Financial services | 2025 |
| Nina Goks Ltd | Other services | 2024 |
| Nine Streets Coffee LLP | | 2018 |
| Nineteen 20 Ltd | Arts & recreation | 2017 |
| Nioh Interiors (Nice in OUR House) Ltd | Construction | 2023 |
| NO Fret Ltd | Hospitality | 2021 |
| NO Going Back Limited | Professional & scientific | 2013 |
| NO WIN NO FEE Limited | Financial services | 2009 |
| NO.1, 1A & 2 Burnside (Holywell) Management Company Limited | Hospitality | 2014 |
| Noble Adscendo Ltd | Professional & scientific | 2018 |
| Noble Investments Limited | Real estate | 2011 |
| Noggin Properties Limited | Real estate | 2012 |
| NON Consulting Limited | Professional & scientific | 2017 |
| Nord Bottle Shop Ltd | Administrative & support | 2017 |
| North Bay Project Management Limited | Professional & scientific | 2024 |
| North Collective Ltd | Health & social care | 2026 |
| North Cottage Management Company Limited | Real estate | 1988 |
| North East 29 Limited | Real estate | 2022 |
| North East Archaeological Solutions Ltd | Professional & scientific | 2026 |
| North East Boiler Maintenance Ltd | Professional & scientific | 2007 |
| North East Child Psychiatry Ltd | Health & social care | 2021 |
| North East Contractors Ltd | Administrative & support | 2020 |
| North East Lasting Power of Attorney Support Ltd | Professional & scientific | 2024 |
| North East Motorcycle Racing Club (1962) Ltd | Arts & recreation | 2013 |
| North East Plastering Ltd | Construction | 2019 |
| North East Property Management Ltd | Real estate | 2018 |
| North East Pubs & Kitchens Ltd | Hospitality | 2021 |
| North East Shades Ltd | Wholesale & retail | 2018 |
| North East Sooty Ltd | Administrative & support | 2018 |