| Cloud Competitions (Cumbria) Ltd | Arts & recreation | 2023 |
| CMC Engineering Ltd | Professional & scientific | 2024 |
| Co-Lab Engineering Limited | Professional & scientific | 2022 |
| Coastal Cottages Cumbria Ltd | Hospitality | 2022 |
| Cockermouth & District Agricultural Society Limited | Administrative & support | 2010 |
| Comscon Ltd | Professional & scientific | 2022 |
| Connor Smith Electrical Ltd | Construction | 2023 |
| Contractual Solutions Limited | Professional & scientific | 2016 |
| Copeland AGE and Advice Service (Caas) C.I.C. | Information & communication | 2019 |
| Copeland Roofing Whitehaven Ltd | Construction | 2025 |
| Copsuk Ltd | Administrative & support | 2013 |
| Country Caps Ltd | Wholesale & retail | 2025 |
| CRA Distribution Ltd | Wholesale & retail | 2023 |
| Cragdon Limited | Administrative & support | 2013 |
| Craimon Construction Limited | Construction | 2019 |
| Crawford M Limited | Wholesale & retail | 2025 |
| Crew Rocks NW Ltd | Arts & recreation | 2024 |
| Crichton Drainage Limited | Water & waste | 2004 |
| Crosbys Fishnchips Limited | Hospitality | 2019 |
| Crown Balloons Limited | Wholesale & retail | 2003 |
| Crux Associates (Cumbria) Ltd | Administrative & support | 2011 |
| CTJ Recovery Ltd | Wholesale & retail | 2022 |
| Cumberland Electrical Wholesalers Limited | Wholesale & retail | 1960 |
| Cumbria Book Festival Limited | Wholesale & retail | 2025 |
| Cumbria Property Development Ltd | Professional & scientific | 2024 |
| Cumbria Transport Ltd | Transport & logistics | 2016 |
| Cumbria Travel Ltd | Administrative & support | 2014 |
| Cumbriaconstruction Limited | Agriculture & fishing | 2025 |
| Cumbrian Consultants Limited | Professional & scientific | 2025 |
| Cumbrian Property Ltd | Real estate | 2025 |
| Curve 21 Limited | Agriculture & fishing | 2026 |
| CWB Property Developments Ltd | Construction | 2022 |
| D Rule Engineering Limited | Professional & scientific | 2024 |
| D'Arcy UK Limited | Professional & scientific | 2006 |
| DA Vinci's Hair Stylist Limited | Other services | 2013 |
| Daata Traders Ltd | Wholesale & retail | 2025 |
| DAN Adair Engineering Ltd | Professional & scientific | 2024 |
| Daniel Dainty Ltd | Information & communication | 2010 |
| Daniells Cottage Management Limited | Other services | 2025 |
| Dark Side City Tours Limited | Administrative & support | 2025 |
| Dartscape UK Ltd | Arts & recreation | 2025 |
| Dave Milling Motorcycles Limited | Wholesale & retail | 2002 |
| DB Assurance Limited | Administrative & support | 2015 |
| DB Inspections (NW) Ltd | Manufacturing | 2013 |
| DBH Property Services Limited | Real estate | 2019 |
| Deano Hendo Limited | Arts & recreation | 2018 |
| Delicious Grill Whitehaven Ltd | Hospitality | 2025 |
| Dentco (Cumbria) Limited | Wholesale & retail | 2004 |
| Derwent Valley Medical Limited | Health & social care | 2023 |
| Design Grid Limited | Administrative & support | 2003 |
| District Paving & Landscaping Limited | Administrative & support | 2022 |
| DJE Financial Services Ltd. | Financial services | 2018 |
| DKW Group Ltd | Hospitality | 2025 |
| Dockside Engineering Design Consultants Ltd | Professional & scientific | 2025 |
| Dondu 94 Limited | Hospitality | 2025 |
| Dot.Webgroup Limited | Wholesale & retail | 2024 |
| DPG Engineering Limited | Professional & scientific | 2003 |
| E Street Properties Limited | Real estate | 2021 |
| Easy Shop Whitehaven Ltd | Wholesale & retail | 2024 |
| Easy ST Ltd | Manufacturing | 2021 |
| Edward D Jones Photography Ltd | Professional & scientific | 2022 |
| Egremont Drop in CIC | Health & social care | 2022 |
| Elec-Mate Ltd | Information & communication | 2025 |
| ELK Quality Services Ltd | Professional & scientific | 2017 |
| Elliot & Black Limited | Wholesale & retail | 2002 |
| Emma Ralls Wealth Management Ltd | Professional & scientific | 2013 |
| Emmsam Ltd | Health & social care | 2024 |
| EMS Cumbria Limited | Professional & scientific | 2024 |
| Engineering Talent Solutions Ltd | Administrative & support | 2025 |
| Ennis & Family Property Development Ltd | Construction | 2024 |
| ESA Mentorship Ltd | Education | 2025 |
| Esra Property Ltd | Real estate | 2024 |
| Everywhere Everything Everyone CIC | Professional & scientific | 2024 |
| Excellence Medical Ltd | Health & social care | 2022 |
| Eyles Engineering Limited | Administrative & support | 2012 |
| F G Developments (Cumbria) Limited | Construction | 2011 |
| F&I Developments Ltd | Real estate | 2024 |
| Facilisync Ltd | Information & communication | 2026 |
| Falcon Court Residents Management Company Limited | Households | 2009 |
| Farm Life West Cumbria CIC | Education | 2022 |
| Fell & Flora Ltd | Manufacturing | 2025 |
| Fellview Investments Ltd | Real estate | 2026 |
| Fenrir Consulting Limited | Other services | 2012 |
| Fenwick Electrical Limited | Construction | 2014 |
| Fici Express Limited | Transport & logistics | 2025 |
| Fiscal Fuzion Ltd | Professional & scientific | 2024 |
| Fisher Eggs Ltd | Agriculture & fishing | 2005 |
| Fitness Xtreme Limited | Arts & recreation | 2022 |
| Flaxuk Limited | Hospitality | 2026 |
| Fobs Eden Limited | Hospitality | 2025 |
| FOREST4TITUDE Frontline Resilience Project CIC | Health & social care | 2026 |
| FOREST4TITUDE Ltd | Other services | 2025 |
| FORMULA4ACTIVITY Limited | Manufacturing | 2016 |
| FOX Reinforcement Limited | Construction | 2013 |
| Fulginium Limited | Information & communication | 2025 |
| Fuseolution Limited | Information & communication | 2025 |
| G&D Sloan Engineering Ltd | Professional & scientific | 2023 |
| G&K Electrical Solutions Limited | Manufacturing | 2019 |
| Gair Bros Electrical Contractors Ltd | Construction | 2025 |
| Galactic Graphics Ltd | Professional & scientific | 2021 |