| Deprag Limited | Manufacturing | 2003 |
| Derbyshire Accountants Limited | Professional & scientific | 2014 |
| Derbyshire Home Developments Limited | Construction | 2014 |
| Desert Streams Limited | Other services | 2009 |
| Desidero Horseboxes Limited | Manufacturing | 2017 |
| Deytech Consultancy Ltd | Professional & scientific | 2026 |
| DF Autoworks Ltd | Wholesale & retail | 2024 |
| Dglp Limited | Agriculture & fishing | 2023 |
| Diamond Hearing Centre Ltd | Health & social care | 2014 |
| Different Tack Limited | Professional & scientific | 2020 |
| Diggers Friend Limited | Professional & scientific | 2001 |
| Digital Rural Limited | Professional & scientific | 2024 |
| Direct Containers (UK) Limited | Other services | 2005 |
| Discount Gaming PCS Ltd | Manufacturing | 2025 |
| Distilled Security Ltd | Professional & scientific | 2015 |
| DKN Consultancy Limited | Professional & scientific | 2023 |
| DLB Photography Limited | Professional & scientific | 2015 |
| DLH Contracts Ltd | Professional & scientific | 2023 |
| Docket Restaurants Ltd | Hospitality | 2017 |
| Dodcott Barns Management Company Limited | Households | 2009 |
| Dominics ROW Ltd | Real estate | 2022 |
| Don'T Mind ME UK - Mental Health Awareness and Suicide Prevention C.I.C. | Health & social care | 2019 |
| DR Jess Aesthetics Ltd | Health & social care | 2019 |
| Draafts Studio Limited | Professional & scientific | 2025 |
| Dragon Elite Roofing and Plastics Ltd | Construction | 2026 |
| Dragon Window Restorations Ltd | Manufacturing | 2021 |
| Drivetrain Solutions Limited | Education | 2009 |
| DSB Holdings Limited | Administrative & support | 2016 |
| DSB Holdings Properties Limited | Real estate | 2018 |
| Dspb Joinery and Construction Limited | Construction | 2025 |
| Dualoption Limited | Other services | 1996 |
| Dunley Water Company Limited | Water & waste | 2005 |
| DXS Management Ltd | Construction | 2011 |
| Dynamic Focus Limited | Professional & scientific | 2022 |
| E J Edgerton & SON Limited | Other services | 2012 |
| E'Leo Productions C.I.C. | Information & communication | 2021 |
| E.C. Cables International Limited | Professional & scientific | 2008 |
| Easigrip Limited | Manufacturing | 1999 |
| Easton Bevins Limited | Professional & scientific | 2007 |
| Eastwood Propco Limited | Real estate | 2025 |
| Easy Shader Limited | Professional & scientific | 2003 |
| Easyfix Property Management Ltd | Construction | 2025 |
| Easyhire Campers Ltd | Wholesale & retail | 2024 |
| Easyhire Motorhomes Ltd | Administrative & support | 2017 |
| Easyhire Plant Limited | Administrative & support | 2010 |
| Easyhire Welfare Limited | Administrative & support | 2015 |
| Easyloo Hire Limited | Administrative & support | 2018 |
| EB Critical Compliance Ltd | Professional & scientific | 2021 |
| EB Critical Engineering Services Ltd | Professional & scientific | 2020 |
| Ebben Communications Ltd | Professional & scientific | 2018 |
| ECD Associates Ltd. | Professional & scientific | 2013 |
| Echologic T Ltd | Wholesale & retail | 2025 |
| Ecotech Sips Ltd | Construction | 2023 |
| EDG Contracting Ltd | Construction | 2026 |
| Edge of the Box Productions Ltd | Arts & recreation | 2022 |
| Ednx Limited | Information & communication | 2017 |
| Edwards MOT Centre Limited | Wholesale & retail | 2010 |
| Effort-Free Media Ltd | Administrative & support | 2012 |
| Ekins Guinness LLP | | 2014 |
| Elegance Natural Skin Care Limited | Extraterritorial | 1999 |
| Elevation Brickwork Limited | Construction | 2015 |
| Elevation Brickwork North West Limited | Construction | 2020 |
| Elite Legionaries the Fort Boxing Club Limited | Education | 2022 |
| Ellesmere Property Holdings Ltd | Real estate | 2021 |
| Ellis Equine Ltd | Agriculture & fishing | 2026 |
| Elmhurst (Shropshire) Ltd | Health & social care | 2017 |
| Emellar Ltd. | Wholesale & retail | 2011 |
| Emerald Irish Holdings Ltd | Real estate | 2025 |
| Emily Dimelow Property Ltd | Real estate | 2026 |
| EMS Design Limited | Professional & scientific | 2014 |
| Enborne Place Management Company Limited | Real estate | 1997 |
| Encore Hospitality (Shropshire) Limited | Hospitality | 2025 |
| Encourage North West Community Interest Company | Health & social care | 2009 |
| Endure Car Protection Ltd | Wholesale & retail | 2025 |
| Engineering & Surveying Partnership Limited | Construction | 2005 |
| English Franca Academy Ltd | Information & communication | 2025 |
| Enigma Investments Limited | Financial services | 2017 |
| Enigma Records Limited | Arts & recreation | 2019 |
| Enjaycue Limited | Information & communication | 2015 |
| Enlightened Business Foundation | Professional & scientific | 2011 |
| Enriching Education Ltd | Education | 2023 |
| Enterprise Security Limited | Professional & scientific | 2017 |
| Envelope Architects Limited | Construction | 2014 |
| Envirapak Holdings Limited | Financial services | 2023 |
| Enviroport Limited | Water & waste | 2025 |
| Enviroscience Limited | Real estate | 2000 |
| Eotas Matters Ltd | Professional & scientific | 2021 |
| Equidem Events Ltd | Administrative & support | 2013 |
| Equistore Ltd | Transport & logistics | 2025 |
| Esmé & Arthur Limited | Professional & scientific | 2013 |
| Ethical Marketing Service Ltd | Professional & scientific | 2015 |
| Etzio Ltd | Hospitality | 2015 |
| European Rallies Limited | Administrative & support | 1990 |
| Euroworld Communications Limited | Information & communication | 1993 |
| Evans House Limited | Real estate | 1972 |
| Evans Projects Ltd | Administrative & support | 2022 |
| Excelsior Data Design Limited | Wholesale & retail | 1994 |
| Expediro Limited | Manufacturing | 1997 |
| Experience UK Media Limited | Administrative & support | 2018 |
| Exterior Matters Ltd | Administrative & support | 2025 |