| Sandsend Hart Ltd | Hospitality | 2026 |
| Sandside Cafe Ltd | Hospitality | 2002 |
| Sandside Cafe Sandsend Ltd | Hospitality | 2022 |
| Sandside Properties (Scarborough) Limited | Real estate | 2025 |
| Sarah Cook Ltd | Hospitality | 2025 |
| Sarah Lindsay Limited | Professional & scientific | 2003 |
| Sarjon Properties (North) Ltd | Real estate | 2018 |
| Saunders Sawmill Limited | Agriculture & fishing | 2001 |
| Saussey Investments Limited | Real estate | 2013 |
| Savy Recycling Ltd | Water & waste | 2025 |
| Scarborough Autos Ltd | Wholesale & retail | 2019 |
| Scarborough Laundry Limited | Administrative & support | 2013 |
| SCI Instrumentation Ltd | Professional & scientific | 2026 |
| Scran (Whitby) Ltd | Wholesale & retail | 2025 |
| Scran @ York House Ltd | Wholesale & retail | 2026 |
| Sea and Iron Ltd | Professional & scientific | 2023 |
| Seabreeze Cleaning (Whitby) Ltd | Administrative & support | 2025 |
| Seaside Apartments Ltd. | Hospitality | 2017 |
| Seaside Cottages (Whitby) Ltd | Administrative & support | 2022 |
| Seataste (International) Limited | Manufacturing | 1994 |
| Seaweed Marketing Solutions Limited | Professional & scientific | 2025 |
| Sedman Minerals 2012 Ltd | Financial services | 2012 |
| Selby Service Centre Ltd | Wholesale & retail | 2012 |
| Senbagh Food Ltd | Hospitality | 2025 |
| Sendure CIC | Health & social care | 2026 |
| Sensible Products Ltd | Manufacturing | 2009 |
| Sfakm Properties Limited | Real estate | 2022 |
| Shared Wealth International Ltd | Administrative & support | 2025 |
| Shaun Graham Ltd | Agriculture & fishing | 2018 |
| Shirenewton Property Consultancy Ltd | Real estate | 2008 |
| Shoreline Cottages Limited | Administrative & support | 1999 |
| Shoreline Whitby Limited | Administrative & support | 2009 |
| SHREDS11 Ltd | Wholesale & retail | 2024 |
| SI Offshore Ltd | Mining & quarrying | 2017 |
| Sigma Tyres & Autocare Ltd | Wholesale & retail | 2025 |
| Silver Street Fisheries Ltd | Hospitality | 2021 |
| Silver Street Management Properties Limited | Extraterritorial | 1999 |
| Silverback Apparel Ltd | Wholesale & retail | 2019 |
| Silverback Chaps Limited | Manufacturing | 2012 |
| Silverback Workwear Ltd | Wholesale & retail | 2019 |
| Simon J. Gibson Limited | Professional & scientific | 2002 |
| Simon Page Holiday Lettings Ltd | Hospitality | 2024 |
| Simply Read Ltd | Wholesale & retail | 2026 |
| Simpson Plant Limited | Construction | 2023 |
| Sitemix Concrete Ltd. | Manufacturing | 2013 |
| SJ Kielty Ltd | Hospitality | 2026 |
| Sleep Sweet Baby Limited | Manufacturing | 2025 |
| Smardale House Residents' Association Limited | Households | 1978 |
| Smilers Properties Ltd | Hospitality | 2022 |
| SMR Safety Limited | Professional & scientific | 2012 |
| Sneaton Hall Management Company Limited | Real estate | 2007 |
| Snmk Leisure Limited | Hospitality | 2003 |
| Social Enterprise International Ltd | Administrative & support | 2003 |
| Solar EAR UK Ltd | Wholesale & retail | 2023 |
| Sophie J Knight Ltd | Hospitality | 2021 |
| SOS Fire Facilities Limited | Administrative & support | 2015 |
| Source Refurb Holdings Ltd | Real estate | 2019 |
| Source Refurb Ltd | Hospitality | 2019 |
| South Bay Beach House Ltd | Hospitality | 2022 |
| Spa House (Whitby) Ltd | Professional & scientific | 2018 |
| Sparkle Developments Limited | Real estate | 2007 |
| Spencer's Home From Home Ltd | Real estate | 2025 |
| Spice Wizard Blends Ltd | Hospitality | 2026 |
| Spring Insights Ltd | Professional & scientific | 2026 |
| SR Freeholds Ltd | Real estate | 2022 |
| Sramd Limited | Mining & quarrying | 2012 |
| ST George Security Limited | Administrative & support | 2009 |
| ST Hilda's Studios of Classical Ballet Ltd | Education | 2025 |
| Stainsacre Self Storage Limited | Administrative & support | 2024 |
| Stakesby Arms Ltd | Hospitality | 2019 |
| Starbright Hideaways Yorkshire Ltd | Administrative & support | 2024 |
| Starfish Accommodation Limited | Hospitality | 2006 |
| Starlight Embroidery Ltd | Wholesale & retail | 2010 |
| Station Tavern Grosmont Ltd | Hospitality | 2025 |
| Steam Cafe Ltd | Hospitality | 2020 |
| Stella Engineering Limited | Agriculture & fishing | 2018 |
| Stephen Watson Unlimited | Financial services | 2021 |
| Steve Trotter Electrical Limited | Construction | 2025 |
| Storm Scaffolding Whitby Limited | Construction | 2021 |
| Stoupe Cross Farm Holidays Limited | Hospitality | 2012 |
| Streoneshalh Ltd | Real estate | 2025 |
| Sum-It Online Services LLP | | 2018 |
| Sunbeam Minerals Limited | Mining & quarrying | 2013 |
| Sunny Pilates Ltd | Arts & recreation | 2025 |
| Sunstar Validation Limited | Professional & scientific | 2007 |
| Suresafe Group Limited | Construction | 2026 |
| Survey Shop (Whitby) Limited | Hospitality | 1991 |
| Swan Farm Minerals Ltd | Mining & quarrying | 2012 |
| Sycamore Villas Management Company Limited | Households | 2016 |
| T & I Enterprise's Ltd | Hospitality | 2020 |
| T Clarkson Building and Landscaping Limited | Construction | 2024 |
| T S Bedingfield Limited | Education | 2025 |
| T&I Enterprise's "the Ship" Limited | Hospitality | 2022 |
| T.Barron & Co. Limited | Transport & logistics | 1957 |
| T.Garbutt Property Limited | Real estate | 2025 |
| Tailor Homes Ltd | Real estate | 2024 |
| Tass Solutions Limited | Information & communication | 2019 |
| Taylors of Whitby Limited | Hospitality | 2025 |
| Teachwise Tutoring (EDU) Ltd | Education | 2023 |
| Tees Direct Ltd | Wholesale & retail | 2019 |