| Rollsco Consulting Limited | Professional & scientific | 2003 |
| Roma Prams Limited | Wholesale & retail | 2017 |
| Roofline Access Limited | Construction | 2005 |
| ROOMS@26 Ltd. | Hospitality | 2017 |
| Rose & Rose Models Ltd. | Professional & scientific | 2019 |
| Roseanna Beauty Limited | Other services | 2025 |
| Rosenkelly Architects Ltd | Professional & scientific | 2026 |
| Ross Sutherland Limited | Construction | 2016 |
| Rossi's Ices Limited | Wholesale & retail | 2002 |
| Route 45 Ltd | Transport & logistics | 2017 |
| RS Holiday Lettings Ltd | Hospitality | 2022 |
| RS Maintenance SW Ltd | Households | 2026 |
| RSI Property Limited | Real estate | 2016 |
| RSJ Properties 2021 Ltd | Real estate | 2021 |
| Ruan Thai Limited | Hospitality | 2005 |
| Ruby's Nails (WM) Limited | Other services | 2023 |
| Russell Orba Ltd | Real estate | 2026 |
| Russett Court Weymouth Limited | Households | 1988 |
| Rustic Consulting Ltd | Manufacturing | 2008 |
| RUT Funk Limited | Wholesale & retail | 2017 |
| RVV Cloud Services Ltd | Information & communication | 2023 |
| RW Battershell Ltd | Agriculture & fishing | 2002 |
| RWB Tax Consultants Limited | Professional & scientific | 2010 |
| Ryan Casey Marine Services Ltd | Agriculture & fishing | 2015 |
| S & K W Ltd | Wholesale & retail | 2003 |
| S & T Birch House Ltd | Real estate | 2013 |
| S & W Shellfish Limited | Agriculture & fishing | 2008 |
| S and C Coffee Services Droitwich Ltd | Hospitality | 2026 |
| S B Autos (Weymouth) Limited | Wholesale & retail | 2017 |
| S Beecroft Solutions Ltd | Wholesale & retail | 2024 |
| S J Roofing Home Improvements Ltd | Construction | 2025 |
| S Mowlam Repairs Ltd | Manufacturing | 2012 |
| S Property Limited | Real estate | 2011 |
| S&R Gregory Limited | Hospitality | 2014 |
| S.L. Williams (Plumbing Services) Ltd | Construction | 2002 |
| S.R. Physio Limited | Health & social care | 2014 |
| SA Jewellers Ltd | Wholesale & retail | 2026 |
| SAA Strategy Ltd | Professional & scientific | 2024 |
| Sachi Properties Ltd | Real estate | 2024 |
| Safe OHM Limited | Construction | 2016 |
| Safespeed Limited | Education | 2012 |
| Sage Services Plumbing & Heating Ltd | Construction | 2026 |
| Sailors Return Weymouth Limited | Hospitality | 2011 |
| Saint Nics CIC | Arts & recreation | 2024 |
| Sajha Catering Limited | Hospitality | 2020 |
| Sakuma Limited | Wholesale & retail | 2011 |
| Salt Steel Stays Ltd | Hospitality | 2024 |
| Saltwatershack Limited | Hospitality | 2025 |
| SAM Buckland Limited | Health & social care | 2015 |
| SAM Polley Plumbing & Heating Limited | Construction | 2013 |
| SAM Riggs Electrical Ltd | Construction | 2016 |
| SAM Webster Racing Limited | Arts & recreation | 2016 |
| Sambo Rodizio Weymouth Ltd | Hospitality | 2019 |
| Sammie Properties Ltd | Real estate | 2019 |
| Sams South West Limited | Wholesale & retail | 2008 |
| Samuels Royce and Oldfield Limited | Financial services | 1982 |
| Sanctuary Gaming Studios Limited | Information & communication | 2025 |
| Sandec Painters Limited | Construction | 2011 |
| Sandfield Wellington Ltd | Real estate | 2024 |
| Sandfords Limited | Administrative & support | 2022 |
| Sanditon (Sidmouth) Management Company Limited | Households | 2012 |
| Sands Development (Weymouth) Limited | Construction | 2018 |
| Sandwich Girls Limited | Hospitality | 2000 |
| Sansara Ltd | Other services | 2026 |
| Sapling Ceramics Limited | Manufacturing | 2024 |
| SAR Electrical & Property Maintenance Limited | Construction | 2022 |
| Sarum Homes Limited | Real estate | 2007 |
| Sash Window Joiners Limited | Construction | 2014 |
| Saunders Property Lettings Ltd | Real estate | 2025 |
| Sawn Limited | Manufacturing | 2022 |
| Sawtell Construction Ltd | Construction | 2004 |
| SB Sparkling Homes Ltd | Administrative & support | 2024 |
| SB Tools (Online) Ltd | Wholesale & retail | 2025 |
| Scaff Search UK Ltd | Construction | 2019 |
| Scallywags Childcare Centre Limited | Administrative & support | 2007 |
| Scarcon Ltd | Administrative & support | 2026 |
| Scard & Mccarthy Building & Steelwork Ltd | Manufacturing | 2004 |
| SCI Events Limited | Arts & recreation | 2016 |
| Scimitar Diving Limited | Transport & logistics | 2015 |
| Scll Classics Limited | Wholesale & retail | 2025 |
| Scll Limited | Transport & logistics | 2009 |
| Scll Property Limited | Real estate | 2025 |
| Scott Sailing Limited | Arts & recreation | 2008 |
| Scott Vevers Ltd | Professional & scientific | 2008 |
| Scottitech Limited | Manufacturing | 2014 |
| SCR Gutter Clear Ltd | Administrative & support | 2018 |
| SD Plumbing & GAS Ltd | Construction | 2020 |
| SDB70 Limited | Financial services | 2022 |
| SDJ Chalets Limited | Real estate | 2019 |
| SDJ Commercial Ltd | Real estate | 2023 |
| SDJ Contracts (Dorset) Limited | Arts & recreation | 2016 |
| Sea & Sky Luxury Transfers Ltd | Transport & logistics | 2026 |
| Sea and Land Limited | Real estate | 2013 |
| Sea Glass Home Designs Limited | Professional & scientific | 2026 |
| Sea SAW Education CIC | Education | 2026 |
| Sea State Engineering Limited | Professional & scientific | 2010 |
| Seacrest Management Company Limited | Households | 1988 |
| Seaforth Estate Management Ltd | Households | 2022 |
| Seaforth Flat Management Ltd | Households | 2022 |
| Seafront Convenience Store Limited | Wholesale & retail | 2018 |