| Safm Holdings Limited | Financial services | 2021 |
| Salinas Investments Ltd | Financial services | 2018 |
| Salkeld Estates Limited | Real estate | 2017 |
| Sally Innes Properties Limited | Real estate | 2015 |
| Samsas Leadership Limited | Professional & scientific | 2020 |
| Samuel Frank Associates Ltd | Administrative & support | 2012 |
| Samuel Frank Holdings Ltd | Administrative & support | 2018 |
| Sandbeck Garage Accessory Shop Limited | Wholesale & retail | 2012 |
| Sandbeck Vets Limited | Professional & scientific | 2019 |
| Sandford Holdings (UK) Limited | Financial services | 2014 |
| Sandmarten Holdings Limited | Financial services | 2008 |
| Sarah Lever Consulting Ltd | Professional & scientific | 2017 |
| Sarah Proctor Aesthetics Ltd | Other services | 2024 |
| Sarhon Homes Limited | Real estate | 2015 |
| Saxon Security GB Limited | Administrative & support | 2012 |
| SAY Access Limited | Construction | 2016 |
| SAY Assets Limited | Construction | 2016 |
| SAY Cheesecake Ltd | Wholesale & retail | 2026 |
| SAY Fitness Limited | Real estate | 2016 |
| SAY Group Limited | Financial services | 2015 |
| SAY Scaffolding Limited | Construction | 2004 |
| Saynor Plumbing & Heating Limited | Administrative & support | 2017 |
| SC Growth Hub Limited | Professional & scientific | 2024 |
| SC Property Hub Limited | Real estate | 2025 |
| Scapeschool Ltd | Health & social care | 2020 |
| Schmidt Golf Ltd | Arts & recreation | 2021 |
| Scoreby Consulting Ltd | Professional & scientific | 2013 |
| Scorfield Building & Landscaping Ltd | Construction | 2022 |
| Scott Mews (Management) Company Limited | Households | 1982 |
| Scotts Arms Ltd | Hospitality | 2018 |
| SCR Adams Consulting Limited | Professional & scientific | 2020 |
| Scrum Facilitators Limited | Information & communication | 2022 |
| Scskm Limited | Public administration | 2012 |
| Sculptured Elegance Limited | Construction | 2004 |
| SDJ One Ltd | Professional & scientific | 2023 |
| SDM Works Limited | Information & communication | 2023 |
| Seacroft Films Investments Limited | Real estate | 2020 |
| Seacroft Films Land Limited | Construction | 2020 |
| Seacroft Films LLP | | 2020 |
| Second Chance Car Finance Limited | Wholesale & retail | 2014 |
| Seconds OUT Combat Sports Management Ltd | Construction | 2010 |
| Security and Safety Limited | Wholesale & retail | 2012 |
| SEF York Limited | Real estate | 2020 |
| SEJ Consulting Limited | Professional & scientific | 2003 |
| Select Building Supplies Limited | Wholesale & retail | 2021 |
| Select Marketing Limited | Professional & scientific | 2025 |
| Seller a Limited | Education | 2023 |
| Sema Limited | Wholesale & retail | 2004 |
| Senergy Industries Ltd | Information & communication | 2023 |
| Sentiment Research Ltd | Professional & scientific | 2014 |
| Sentinel Cyber Consulting Ltd | Information & communication | 2025 |
| Serelia Studio Limited | Other services | 2026 |
| Seta Consultancy Limited | Administrative & support | 2014 |
| Seven Deuce Ltd | Wholesale & retail | 2016 |
| SF Luxe Ltd | Wholesale & retail | 2022 |
| SGL Sports Limited | Professional & scientific | 2025 |
| SGP (UK) Ltd | Construction | 2014 |
| SH Financial Services Ltd | Professional & scientific | 2023 |
| Shadowfax Funding Solutions Limited | Financial services | 2020 |
| Shaun Thorpe Independent Funeral Directors Limited | Other services | 2026 |
| Sheard Associates Ltd | Professional & scientific | 2011 |
| Sheavyn Associates Financial Management Limited | Financial services | 2014 |
| Sheilworth Limited | Extraterritorial | 1948 |
| Sheq Management Systems Ltd | Professional & scientific | 2009 |
| Shiki Ltd | Hospitality | 2026 |
| Shine Creative Design Limited | Professional & scientific | 2009 |
| Shire Oak Properties Limited | Real estate | 2025 |
| Shooshyne Limited | Manufacturing | 1969 |
| Show OFF Dog Grooming Ltd | Other services | 2022 |
| Show OFF Doggy Daycare Ltd | Other services | 2022 |
| Showground Properties Limited | Real estate | 2021 |
| Shudaya Residences Limited | Real estate | 2025 |
| Shuei Trading UK Ltd | Wholesale & retail | 2018 |
| Sidekick Agency Limited | Professional & scientific | 2025 |
| Sierra Bravo Consultancy Ltd | Professional & scientific | 2014 |
| Sigmasys Limited | Professional & scientific | 2013 |
| Sigo Investments Limited | Financial services | 2022 |
| Silvae Limited | Professional & scientific | 2022 |
| Silver Buck Limited | Professional & scientific | 2018 |
| Silverfox Global Limited | Wholesale & retail | 2002 |
| Simister Properties Ltd | Real estate | 2026 |
| Simmons Properties (Wetherby) Limited | Real estate | 2022 |
| Simon Benn Ltd | Information & communication | 2011 |
| Simon Dewhurst Photography Limited | Professional & scientific | 2007 |
| Simon J Limited | Other services | 2011 |
| Simply Wedding Dresses Ltd | Wholesale & retail | 2007 |
| Single USE Alternatives Limited | Wholesale & retail | 2019 |
| SIP Investment Properties Limited | Construction | 2013 |
| SIP Properties LLP | | 2013 |
| Sirius Logistics Yorkshire Limited | Transport & logistics | 2018 |
| Siriwan Ltd | Hospitality | 2018 |
| SIT Stand Work Limited | Wholesale & retail | 2016 |
| Site Height Ltd. | Administrative & support | 2002 |
| Sixth Wave Ventures Limited | Professional & scientific | 2022 |
| SJ Account Solutions Ltd | Professional & scientific | 2011 |
| SJ Yorkshire Fabrications Ltd | Manufacturing | 2024 |
| SJH Reinforcements Ltd | Administrative & support | 2003 |
| SJL Legal Limited | Professional & scientific | 2018 |
| SJZ Consulting Ltd | Professional & scientific | 2025 |
| Skiddaw Holidays Ltd | Hospitality | 2024 |