| Salon Concepts Holdings Limited | Financial services | 2022 |
| Salon Concepts Limited | Wholesale & retail | 2003 |
| Salt and Malt WSM Ltd | Hospitality | 2025 |
| Salt and Petal Ltd | Wholesale & retail | 2024 |
| Salty Sea Weston Ltd | Hospitality | 2024 |
| Salus International Consulting Ltd | Extraterritorial | 2023 |
| SAM Adamson Plastering Ltd | Construction | 2026 |
| Samaaliproperties Limited | Real estate | 2023 |
| Samson (SW) Ltd | Construction | 2019 |
| Samuel Main Coaching Ltd | Other services | 2020 |
| Sand Bay Market Ltd | Wholesale & retail | 2025 |
| Sandfield Accounting Limited | Professional & scientific | 2013 |
| Sandford Court (WSM) Management Company Limited | Households | 2003 |
| Sandy Beach (WSM) Ltd | Real estate | 2008 |
| Sanlion Co., Ltd | Administrative & support | 2021 |
| Santon Holdings Ltd | Financial services | 2018 |
| Santoro Property Services Limited | Construction | 2024 |
| SAO Events Ltd | Hospitality | 2026 |
| SAO WSM Ltd | Hospitality | 2026 |
| Sapiens Property Services Limited | Professional & scientific | 2010 |
| Sapling IT Solutions Limited | Information & communication | 2025 |
| Saredy Limited | Wholesale & retail | 2026 |
| Sarno Ltd | Wholesale & retail | 2023 |
| Sarrisco Ltd | Information & communication | 2024 |
| Sasho Construction Ltd | Construction | 2020 |
| Satin Stainless (Contracts) Limited | Manufacturing | 1991 |
| Satin Stainless Architectural Metalwork Limited | Manufacturing | 2021 |
| Satin Stainless Fabrications Limited | Manufacturing | 1999 |
| Satin Stainless Holdings Limited | Financial services | 2018 |
| Satin Stainless Properties Ltd | Construction | 2019 |
| Saturley Garner & Co. Ltd | Real estate | 2008 |
| Saturncall Limited | Professional & scientific | 2008 |
| Saved by HIS Grace Limited | Other services | 2018 |
| Savoy Beach Hotel Limited | Hospitality | 2024 |
| Savoy-Consulting-Group Limited | Extraterritorial | 2020 |
| Saxon Court Apartments (WSM) Limited | Households | 1992 |
| Sayera Ltd | Wholesale & retail | 2005 |
| SBK Engineering Ltd | Professional & scientific | 2007 |
| SC Kiosk Ltd | Wholesale & retail | 2023 |
| Sceptre Security Ltd | Administrative & support | 2020 |
| School Sports Teaching and Behaviour Management Limited | Arts & recreation | 2006 |
| Schroeder Bros. Transport Ltd | Transport & logistics | 2015 |
| Scott and Scott Investments Ltd | Real estate | 2024 |
| Scott Enterprise Holdings Ltd | Financial services | 2025 |
| Scott Kelly Partnership Limited | Arts & recreation | 2004 |
| Scott's Services (South West) Ltd | Arts & recreation | 2013 |
| Screenswap Ltd | Wholesale & retail | 2024 |
| Scwbuilders Ltd | Construction | 2020 |
| SD Landscapes Ltd | Administrative & support | 2020 |
| SDT Consultancy Services Ltd | Professional & scientific | 2019 |
| Sea Horse Management Company Limited | Households | 1991 |
| Seafarers & Co Ltd | Hospitality | 2017 |
| Seafield Court (Weston-Super-Mare) Management Limited | Households | 1973 |
| Seal Mortgage Solutions Ltd | Financial services | 2014 |
| Sean Cardwell Windows Ltd | Construction | 2016 |
| Seaside Homes (WSM) Ltd | Real estate | 2021 |
| Seasonal Posies Ltd | Wholesale & retail | 2024 |
| Seaview Business Solutions Ltd | Water & waste | 2023 |
| Seaview Therapies Ltd | Health & social care | 2022 |
| Seaward Way Minehead Management Limited | Households | 2002 |
| Secure Door Direct Ltd | Wholesale & retail | 2013 |
| Secure Inheritance Legal Services Limited | Professional & scientific | 2018 |
| Secure Parking and Storage Limited | Real estate | 1998 |
| Secure Parking Property Limited | Real estate | 2016 |
| Secure Plan Investments Ltd | Real estate | 2023 |
| Security Plus Systems Ltd | Professional & scientific | 2008 |
| Sedgemoor Publicity Ltd | Administrative & support | 2010 |
| SEI Clothing Ltd | Wholesale & retail | 2025 |
| Selby Management Company Limited | Households | 2016 |
| Selcore Limited | Professional & scientific | 2015 |
| Select Property (South West) Ltd | Real estate | 2019 |
| Selou Group Limited | Construction | 2022 |
| Selou Homes Limited | Real estate | 2021 |
| Semper Legere Limited | Professional & scientific | 2023 |
| Senel Trading Company Limited | Administrative & support | 2016 |
| Sensory Spaces U.K. Ltd | Health & social care | 2025 |
| SEO Lady Ltd | Information & communication | 2011 |
| Serenity Hair Weston Ltd | Other services | 2019 |
| Serita Limited | Extraterritorial | 2017 |
| Servonix Information Technology Ltd | Information & communication | 2026 |
| Session Ltd | Information & communication | 2018 |
| Seventy SIX Financial Planning Ltd | Professional & scientific | 2022 |
| Severin Ltd | Transport & logistics | 2019 |
| Severn Building & Roofing Limited | Administrative & support | 2016 |
| Severnside Roofing (SW) Ltd | Construction | 2025 |
| SEW Solutions Limited | Professional & scientific | 2015 |
| SFC Weston Ltd | Hospitality | 2022 |
| SFM Maintenance Ltd | Construction | 2024 |
| Sgfisher Properties Ltd | Real estate | 2024 |
| SH & Arvel Limited | Water & waste | 2016 |
| Shanghai PAN Limited | Hospitality | 2018 |
| Shaparack Ltd | Agriculture & fishing | 2019 |
| Sharon James HR Solutions Ltd | Professional & scientific | 2010 |
| Sharps Glazing Ltd | Construction | 2023 |
| Shaw Care SW Limited | Health & social care | 2018 |
| SHC (Weston-Super-Mare) Limited | Health & social care | 2013 |
| Shed and Breakfast Limited | Hospitality | 2016 |
| Sheen Supermarket Ltd | Wholesale & retail | 2025 |
| Shelley Construction Limited | Construction | 2002 |
| Shepherds Way Management Limited | Households | 2005 |