| Sanmar Technical Design Limited | Professional & scientific | 2011 |
| Santo Sammartino Engineering Ltd | Professional & scientific | 2011 |
| SB Electrical (Scotland) Ltd | Construction | 2015 |
| SC Design Solutions Ltd | Professional & scientific | 2011 |
| Scapa Energy Ltd | Professional & scientific | 2014 |
| Schools OUT! Club (Westhill) Ltd | Health & social care | 2017 |
| Scio Tech Soft Limited | Information & communication | 2014 |
| Scofu Limited | Hospitality | 2024 |
| Scorsa Limited | Hospitality | 2020 |
| Scotfilm Ltd | Information & communication | 2023 |
| Scotia Apartments Ltd | Real estate | 2019 |
| Scotsafe Property Solutions Ltd | Real estate | 2025 |
| Scott James & Associates Ltd | Financial services | 2019 |
| Scott Robertson Associates Limited | Professional & scientific | 2009 |
| Seabrokers Limited | Administrative & support | 2004 |
| Seabrokers Property Limited | Real estate | 2007 |
| Seasons Pride Gardening Services Ltd | Administrative & support | 2019 |
| Semco Maritime Limited | Manufacturing | 1978 |
| Senergy OIL & GAS Limited | Mining & quarrying | 2008 |
| Senergy Wells Limited | Mining & quarrying | 2002 |
| Setaris Konsult Ltd | Information & communication | 2017 |
| Setaris UK Limited | Real estate | 2013 |
| SGR Autos Ltd | Wholesale & retail | 2019 |
| Shen Marine Ltd | Mining & quarrying | 2024 |
| Signature M2 Ltd | Wholesale & retail | 2026 |
| Silicon Surfer Limited | Other services | 2007 |
| Simms Electrical Engineering Limited | Professional & scientific | 2014 |
| Simpson Computer Consultants Limited | Real estate | 1995 |
| Sinclair Energy Solutions Ltd | Professional & scientific | 2024 |
| SIP ARC Ltd | Professional & scientific | 2023 |
| Sisterland UK Ltd | Health & social care | 2004 |
| SJS Entertainment Ltd. | Information & communication | 2005 |
| SJT Engineering Limited | Professional & scientific | 2002 |
| SK Electrical Ltd | Construction | 2023 |
| Skene Energy Limited | Administrative & support | 2020 |
| Sklk Labs Limited | Information & communication | 2025 |
| SL Drillcost Limited | Real estate | 2010 |
| Slack Sling Engineering Ltd | Professional & scientific | 2024 |
| Slawomir Rukat Limited | Construction | 2017 |
| Slkko Global Limited | Financial services | 2025 |
| Smart Thinking Finance Ltd | Financial services | 2021 |
| Smarter Subsea (Holdings) Limited | Manufacturing | 2016 |
| Smartwellservices Ltd | Mining & quarrying | 2014 |
| SNM Surveys Ltd | Professional & scientific | 2018 |
| SNO' What - SNO' Problem Ltd. | Professional & scientific | 2011 |
| SO Professional Services Ltd | Professional & scientific | 2025 |
| Solution Sales Ltd | Wholesale & retail | 2022 |
| Solvix AI Ltd | Information & communication | 2025 |
| South Auchronie Farm Ltd | Agriculture & fishing | 2026 |
| South Fornet Estates Limited | Agriculture & fishing | 1981 |
| South West Aberdeenshire Citizens Advice Bureau | Information & communication | 2009 |
| SP Access Ltd | Construction | 2023 |
| Sparkling Flame Ltd | Wholesale & retail | 2022 |
| Specialist Coating (Scotland) Limited | Mining & quarrying | 2017 |
| SPR Materials Engineering Limited | Other services | 2012 |
| Springdon Limited | Real estate | 2011 |
| Springgen Advice Ltd | Financial services | 2019 |
| Squire Associates (Aberdeen) Ltd | Professional & scientific | 2013 |
| SRI Sumukhaa Audit Solutions Ltd | Administrative & support | 2025 |
| ST Columba Care Ltd | Health & social care | 2026 |
| Stanley Clark Limited | Wholesale & retail | 1984 |
| Star Light Aberdeen Ltd | Hospitality | 2025 |
| Steinbach Mortgage Management Ltd | Financial services | 2018 |
| Step and Stone Health Ltd | Health & social care | 2020 |
| Steve Brands (Holdings) Limited | Financial services | 2019 |
| Steve's Joinery Services Limited | Professional & scientific | 2003 |
| Stewart Bagpipe Supplies Ltd | Manufacturing | 2020 |
| Stfm Engineering Ltd. | Professional & scientific | 2009 |
| Stjm Engineering Ltd | Other services | 2022 |
| Stogies Ltd | Wholesale & retail | 2024 |
| Stormgeo Limited | Professional & scientific | 2009 |
| Strathryach Ltd | Professional & scientific | 2019 |
| Streetwise Real Estate Limited | Real estate | 2011 |
| Sub-Drill Supply Limited | Manufacturing | 1992 |
| Subsea 7 (UK Service Company) Limited | Administrative & support | 2002 |
| Subsea 7 Blue Space Limited | Other services | 1990 |
| Subsea 7 Chartering (UK) Limited | Administrative & support | 1998 |
| Subsea 7 Deep Sea Limited | Administrative & support | 2003 |
| Subsea 7 I-Tech Limited | Mining & quarrying | 2013 |
| Subsea 7 Pipeline Production Limited | Mining & quarrying | 1982 |
| Subsea Micropiles (UK) Ltd | Construction | 2021 |
| Summits HR Consultancy Limited | Other services | 2010 |
| Sundial Consultancy Ltd | Professional & scientific | 2025 |
| Suzanne Whitney Ghadimi Arts Ltd | Arts & recreation | 2024 |
| SW Subsea Engineering Services Limited | Real estate | 2011 |
| Swiftwell Ltd | Professional & scientific | 2020 |
| Sybarite Aviation & Equine Services Limited | Agriculture & fishing | 2014 |
| Sylhet Ventures Ltd | Real estate | 2015 |
| Synxera Ltd | Information & communication | 2025 |
| T&L Ramage Limited | Professional & scientific | 2023 |
| Tartan Paint Ltd | Professional & scientific | 2024 |
| TBV Inspection Services Limited | Professional & scientific | 2012 |
| Technipfmc Island Offshore Subsea UK Limited | Professional & scientific | 2018 |
| Tendeka Limited | Financial services | 2022 |
| Texo Asset Integrity Limited | Construction | 2018 |
| Texo Engineering Limited | Construction | 2018 |
| Texo Fabrication Limited | Manufacturing | 2018 |
| Texo Technologies Limited | Information & communication | 2021 |
| Texo Workspace Solutions Limited | Construction | 2018 |
| Thank Evans Childcare Agency Limited | Other services | 2007 |