| Sine Computer Services Limited | Professional & scientific | 1981 |
| Sinister Detailing Limited | Administrative & support | 2023 |
| Sixteen 12 Collectibles Limited | Manufacturing | 2004 |
| SLB Logistic Services Consultancy Ltd | Administrative & support | 2022 |
| Sleeman Carpentry Ltd | Manufacturing | 2020 |
| Sleepcraft Limited | Wholesale & retail | 1982 |
| SLS UK Holdings Ltd | Wholesale & retail | 2023 |
| Smallbrook Property Ltd | Construction | 1950 |
| Smartmove Estates Limited | Real estate | 2009 |
| Smiths Heating Solutions Ltd | Construction | 2021 |
| SNG Scaffolding Ltd | Construction | 2022 |
| Snook Tanswell Property Limited | Real estate | 2024 |
| Softlinks UK Limited | Professional & scientific | 2018 |
| Sophiestudio Ltd | Professional & scientific | 2013 |
| South West Catering Installations Limited | Manufacturing | 2025 |
| South West Rust Proofing Ltd | Wholesale & retail | 2019 |
| South West Stainless Ltd | Construction | 2013 |
| Southcroft Business Service & Agents Limited | Wholesale & retail | 2011 |
| Southern Precision Limited | Manufacturing | 2000 |
| Southview Stonemasonry Limited | Construction | 2010 |
| Southwick Newsagent Ltd | Wholesale & retail | 2017 |
| SPC Corporate Consultancy LLP | | 2020 |
| SPC Corporate Limited | Manufacturing | 2008 |
| SPC Europe Limited | Manufacturing | 2000 |
| SPC Information Systems Limited | Information & communication | 2017 |
| SPC IP Ltd | Financial services | 2020 |
| SPC Power Solutions Limited | Manufacturing | 2018 |
| Spectra Coachbuilding Ltd | Manufacturing | 2012 |
| Spectra Innovations Limited | Manufacturing | 2014 |
| Spectra Specialist Engineering Limited | Manufacturing | 1987 |
| Spindrift UK Limited | Wholesale & retail | 2005 |
| Spray FX Ltd | Wholesale & retail | 2022 |
| SPS Services Trowbridge Ltd | Construction | 2024 |
| Spur Healthcare Ltd | Health & social care | 2023 |
| Square 1 Communications Limited | Information & communication | 2002 |
| Square World Communications Limited | Information & communication | 2005 |
| Square World TV Services Limited | Information & communication | 2011 |
| SR Trenchworks Ltd | Construction | 2014 |
| Sssha Holdings Limited | Real estate | 2025 |
| Stan West Ltd | Wholesale & retail | 2019 |
| Stan West Property Ltd | Real estate | 2024 |
| Stan West Stores Ltd | Wholesale & retail | 2025 |
| Star East Ltd | Hospitality | 2024 |
| Steve Blundell Ltd | Transport & logistics | 2014 |
| Stills & Motion Media Limited | Information & communication | 2019 |
| Stokes Marsh AD Ltd | Energy | 2016 |
| STONYSTREET1 Limited | Real estate | 2023 |
| Storemore Holdings Ltd | Arts & recreation | 2026 |
| Stormfree Holdings Ltd | Manufacturing | 2013 |
| Stratmore Group Ltd | Information & communication | 2023 |
| Stripy Fish Networks Limited | Information & communication | 2003 |
| Stuart Electrical Ltd | Construction | 2021 |
| Sturman Craig Building Services Limited | Real estate | 2021 |
| Sturman Craig Electrical Services Limited | Construction | 2018 |
| Sturman Craig Property Ltd | Real estate | 2025 |
| Styles of Bath Ltd | Construction | 2013 |
| Superior Autos Limited | Wholesale & retail | 2019 |
| Swerve Cycling Limited | Wholesale & retail | 2014 |
| Swipe Limited | Extraterritorial | 1998 |
| Syngetico Limited | Financial services | 2024 |
| T Gill Antiques Ltd | Wholesale & retail | 2024 |
| T J Gillman Limited | Wholesale & retail | 2000 |
| T Shirt & Sons Limited | Manufacturing | 2003 |
| T.D.S Garden Landscaping Ltd | Administrative & support | 2018 |
| T.H.F. Johnson Limited | Agriculture & fishing | 1954 |
| T21 Group Ltd | Professional & scientific | 2017 |
| Tarkocin Ltd | Hospitality | 2023 |
| Tbdm Consulting Ltd | Information & communication | 2016 |
| Teacher Wellness Club Ltd | Wholesale & retail | 2025 |
| Team Rollo Ltd | Arts & recreation | 2024 |
| Tecfrontiers Ltd | Manufacturing | 2009 |
| Techdex Ltd | Information & communication | 2023 |
| Techtrend Hub Ltd | Wholesale & retail | 2023 |
| Tenancy Expert Limited | Real estate | 2018 |
| Terrawarm | | 2004 |
| TES Transmissions Limited | Manufacturing | 1974 |
| TF Tuned Ltd | Financial services | 2018 |
| THE AD People Ltd | Professional & scientific | 2025 |
| THE Analytics Partnership Ltd | Administrative & support | 2016 |
| THE Candle Kitchen Limited | Manufacturing | 2010 |
| THE Candlin Canonbury Estate Limited | Real estate | 2015 |
| THE Castle Trowbridge Ltd | Hospitality | 2025 |
| THE Country Facilities Company Limited | Administrative & support | 2026 |
| THE Digital Hive Studio Ltd | Information & communication | 2024 |
| THE Frome Letting Centre Limited | Real estate | 2010 |
| THE Fullen Building Company Ltd | Construction | 2024 |
| THE Grumpy GIT Brewery Limited | Manufacturing | 2017 |
| THE Healing Link Ltd | Information & communication | 2026 |
| THE Horse and Groom Westbury Ltd | Hospitality | 2025 |
| THE Infrastructure Design Consultancy Limited | Professional & scientific | 2015 |
| THE Interalia Centre | Education | 2011 |
| THE Local Gym Company Limited | Arts & recreation | 2022 |
| THE National Plant and Equipment Register Limited | Information & communication | 1995 |
| THE NP Agency Ltd | Wholesale & retail | 2025 |
| THE Podiatry People Ltd | Health & social care | 2026 |
| THE Print Smith Limited | Manufacturing | 2019 |
| THE Rainbow Goddess Ltd | Health & social care | 2020 |
| THE Studio Frome Limited | Other services | 2021 |
| THE Tax Advice Centre Limited | Professional & scientific | 2010 |
| THE Twisted Brewing Company Limited | Manufacturing | 2013 |