| Rapid Docklands Limited | Real estate | 2006 |
| Rascion Ltd | Information & communication | 2021 |
| Raso Group Ltd | Administrative & support | 2024 |
| Ratio Business Services Limited | Professional & scientific | 2003 |
| RE-GEN8 Ltd | Information & communication | 2009 |
| Realise ED Ltd | Other services | 2015 |
| Realise Education Ltd | Education | 2018 |
| Realiseme Ltd | Financial services | 2018 |
| Redwoods (Welwyn) Management Limited | Real estate | 1988 |
| Reel Talk Ltd | Information & communication | 2019 |
| Reg's Coaches Limited | Transport & logistics | 1962 |
| Reid Chiropractic Limited | Health & social care | 1998 |
| Resourceco Limited | Administrative & support | 2025 |
| Retail Protocol Ltd | Information & communication | 2017 |
| Reutli Properties Limited | Information & communication | 2006 |
| REV Media Limited | Professional & scientific | 2019 |
| Reveale Consultants Limited | Professional & scientific | 2026 |
| Rewardmonies Ltd | Information & communication | 2023 |
| Reynards Road Residents Association Ltd | Households | 2010 |
| RGW Cherry and Associates Limited | Professional & scientific | 1993 |
| Richard Munns Chauffeur Services Limited | Transport & logistics | 2007 |
| Riviera Executive Travel Ltd | Other services | 2012 |
| RN3 Orthopaedics Ltd | Health & social care | 2018 |
| Robert Courtneidge Ltd | Professional & scientific | 2024 |
| Roberts Three Daughters Ltd | Real estate | 2025 |
| Rogue Digital VFX Limited | Information & communication | 2017 |
| Roots of Unity Limited | Real estate | 2000 |
| Rose and Crown Tewin Ltd | Hospitality | 2017 |
| Ross Professional Driving Services Limited | Transport & logistics | 2025 |
| Rothesay Residentials Limited | Real estate | 2017 |
| Rougemont Capital Ltd | Financial services | 2025 |
| RS Partnership Limited | Professional & scientific | 2017 |
| RS Welwyn Limited | Professional & scientific | 2009 |
| Rural GM Ltd | Other services | 2024 |
| Rymac Limited | Professional & scientific | 2018 |
| Saints Homes Limited | Construction | 2017 |
| Sameday Path Ltd | Health & social care | 2025 |
| Samuri Conversions Ltd | Wholesale & retail | 2014 |
| Scanworx Limited | Construction | 2020 |
| SCJ Biopharm Consultancy Ltd | Information & communication | 2021 |
| Scoop Consultancy Limited | Professional & scientific | 2017 |
| SD Smith Consultancy Ltd | Professional & scientific | 2016 |
| Sdsia Ltd | Real estate | 2025 |
| Sealfix Cladding Systems Limited | Construction | 2012 |
| Searle Wealth Management Ltd | Professional & scientific | 2011 |
| Seaview Teignmouth Limited | Hospitality | 2023 |
| Secret Olives Ltd | Hospitality | 2023 |
| Sehiti Plumbing and Heating Ltd | Construction | 2026 |
| Sell Convey Limited | Real estate | 2026 |
| SG Finance Ltd | Financial services | 2007 |
| SGA Corporate Limited | Professional & scientific | 2024 |
| Shaftesbury (Unit 16) Limited | Real estate | 2007 |
| Shared Churches (Hertfordshire and Bedfordshire) Limited | Real estate | 1972 |
| Shawe Engineering Ltd | Manufacturing | 2021 |
| Shawe Steam Services Limited | Manufacturing | 1988 |
| Shelf Talk Limited | Manufacturing | 2026 |
| Sherrardswood Limited | Education | 2017 |
| Sherwin Bros Ltd | Administrative & support | 2018 |
| Shire Park Bowls Club (Tewin) Limited | Arts & recreation | 1994 |
| SHK Capital Limited | Real estate | 2010 |
| Showering Monkey Limited | Extraterritorial | 2009 |
| Simkatso Ltd | Households | 2019 |
| Simon Consultancy Ltd | Real estate | 2007 |
| Simon Garner Golf Ltd | Arts & recreation | 2018 |
| Simply Homes Sales Limited | Real estate | 2018 |
| Simplytech Consulting Ltd | Information & communication | 2025 |
| SIP Sessions Ltd | Hospitality | 2021 |
| SJ MOT Ltd | Wholesale & retail | 2022 |
| SK Identity Consulting Ltd | Professional & scientific | 2023 |
| Skyblue Healthcare Associates Ltd | Professional & scientific | 2011 |
| Skyblue Healthcare Ltd | Professional & scientific | 2025 |
| SLS Event Equipment Limited | Administrative & support | 2019 |
| Smartvan Logistics Ltd | Transport & logistics | 2026 |
| SMS Consult Limited | Professional & scientific | 2005 |
| Softcore Limited | Information & communication | 2003 |
| Software AS a Service Ltd | Information & communication | 2026 |
| Solutions in Retirement Ltd | Financial services | 2020 |
| Soma Consulting Partnership Ltd | Professional & scientific | 2016 |
| South East London Estates Limited | Real estate | 2008 |
| South Group Ltd | Information & communication | 2021 |
| Space Heating Limited | Construction | 2007 |
| Spencer James Estates Ltd | Real estate | 2021 |
| Sporting Adventures Ltd | Arts & recreation | 2014 |
| Sproga Ltd | Other services | 2019 |
| Square Roots of Unity Limited | Real estate | 2002 |
| SRA Industries Limited | Information & communication | 2017 |
| SRP Homes Ltd | Real estate | 2024 |
| Starlight Rentals Limited | Administrative & support | 2025 |
| Starline Construct Ltd | Construction | 2020 |
| Stascuro Ltd | Professional & scientific | 2018 |
| Stay New Homes Limited | Construction | 2016 |
| Staysavvy Ltd | Information & communication | 2020 |
| Steeze Ltd | Wholesale & retail | 2026 |
| Stone by Stone Properties Limited | Real estate | 2017 |
| Storming Through Life Ltd | Health & social care | 2020 |
| Stratos Associates Limited | Professional & scientific | 2006 |
| Strawberry Fields Care Farm C.I.C. | Education | 2024 |
| Strawberry Fields Property Ltd | Real estate | 2023 |
| Strictly Strategic Limited | Wholesale & retail | 2024 |
| Stronger Healthcare Ltd | Health & social care | 2023 |