| Romany Caravans Limited | Wholesale & retail | 2022 |
| Rowan Caerhowel Management Limited | Households | 2023 |
| Rrll Holdings Limited | Financial services | 2026 |
| RRR Property Limited | Real estate | 2017 |
| RSJ Contracting Limited | Construction | 2022 |
| S J R Holdings Limited | Professional & scientific | 2006 |
| S J Rivara Ltd | Professional & scientific | 2019 |
| S J Roberts (Group) Ltd | Professional & scientific | 2014 |
| S J Roberts Homes Limited | Real estate | 2016 |
| S&C New Sports Ltd | Hospitality | 2025 |
| S&C Welshpool Ltd | Arts & recreation | 2020 |
| S&S Good Stuff Ltd | Wholesale & retail | 2021 |
| S.J. Roberts Construction Limited | Construction | 1996 |
| S.M. Davies Transport Limited | Transport & logistics | 2007 |
| Sage Aviation Ltd | Financial services | 2019 |
| Salissa Ltd | Professional & scientific | 2011 |
| Sally's Rocking Horses Limited | Wholesale & retail | 2005 |
| Sam's Kebabs and Pizzas Ltd | Hospitality | 2017 |
| Sanderson's Fine Furniture & Joinery Ltd | Manufacturing | 2008 |
| Sarah Cadwallader Ltd | Professional & scientific | 2024 |
| Sarah's Wardrobe Ltd | Wholesale & retail | 2018 |
| SB Metalcraft Limited | Manufacturing | 2015 |
| Secure Vending Systems Limited | Manufacturing | 2010 |
| Severn Transport Services Ltd | Transport & logistics | 2019 |
| Severn Windows Limited | Wholesale & retail | 2020 |
| Severnside Milkers Ltd | Agriculture & fishing | 2019 |
| SG Safety and Management Services Limited | Professional & scientific | 2022 |
| Shan Barber Ltd | Other services | 2026 |
| Sharon E Davies Ltd | Other services | 2017 |
| Sheen Services Ltd | Wholesale & retail | 2013 |
| Shire Valley Limited | Construction | 2011 |
| Shropshire Hire Limited | Administrative & support | 2013 |
| Shropshire Transport Ltd | Transport & logistics | 2014 |
| Sidoli Holdings Limited | Professional & scientific | 2016 |
| Signcityuk Ltd | Manufacturing | 2016 |
| SL Jones PUB Co Limited | Hospitality | 2026 |
| Small Animal Endoscopy Referrals Ltd | Professional & scientific | 2024 |
| Small Box Prizes Limited | Wholesale & retail | 2025 |
| Sola Property & Investments Limited | Real estate | 2023 |
| Sound & Vision Installations Ltd | Construction | 2001 |
| Spalding Project Management Ltd | Other services | 2018 |
| Sparkle and Swank Limited | Wholesale & retail | 2025 |
| Spectrum Services Limited | Construction | 2006 |
| Splash Plumbing & Heating Engineers Limited | Construction | 2012 |
| SS Welshpool Ltd | Arts & recreation | 2020 |
| SSR Mobility Ltd | Manufacturing | 2025 |
| Stainless Pipe Solutions Ltd | Construction | 2003 |
| Stainless Process Solutions Ltd | Construction | 2024 |
| State of the Art Software Ltd | Information & communication | 2014 |
| Stenia Developments Ltd | Real estate | 2026 |
| Stepchange Personnel Limited | Administrative & support | 2004 |
| Steve Gittins Transport Ltd | Transport & logistics | 2021 |
| Stiwdiohud Ltd | Agriculture & fishing | 2012 |
| Stourbridge Glass Engravers Limited | Wholesale & retail | 2002 |
| Strawberry Week Limited | Wholesale & retail | 2020 |
| STS Storage & Distribution Limited | Transport & logistics | 2024 |
| Studio Eco Ltd | Professional & scientific | 2019 |
| Studio Snape Ltd | Professional & scientific | 2020 |
| Suerte Consulting Ltd | Professional & scientific | 2016 |
| Sun Forge Limited | Agriculture & fishing | 2003 |
| Sundorne Products (Llanidloes) Limited | Water & waste | 1997 |
| SWG Construction (Build & Renovate) Ltd | Construction | 2002 |
| SWG Group Ltd | Financial services | 2019 |
| SWG Homes Ltd | Construction | 2017 |
| SWG Leisure Ltd | Extraterritorial | 2017 |
| SWG M&E (Design & Install) Ltd | Construction | 2017 |
| Swift Solutions INT Limited | Information & communication | 2023 |
| Swifts Garage (Longton) Limited | Real estate | 1970 |
| Sychtyn Limited | Agriculture & fishing | 2026 |
| Synchro Europe Limited | Administrative & support | 2015 |
| T.D. Freedom Ltd | Real estate | 2019 |
| Tai-Sabaki (Body Management) Limited | Health & social care | 2000 |
| Talbot Hotel (2009) Limited | Hospitality | 2009 |
| TAN Y Dderwen Eggs Ltd | Wholesale & retail | 2026 |
| Tarian Technology Ltd | Manufacturing | 2018 |
| TE & SE Estates Limited | Real estate | 2016 |
| Team Nicoll Ltd | Arts & recreation | 2022 |
| Technocover Ltd. | Manufacturing | 1993 |
| Techwoman Limited | Professional & scientific | 2021 |
| Techwomen Limited | Professional & scientific | 2021 |
| Tellan Puppies Limited | Agriculture & fishing | 2019 |
| TGR Fencing Ltd | Administrative & support | 2025 |
| Thames Promenade | Construction | 2002 |
| THE Barbers Shop Ltd | Administrative & support | 2019 |
| THE Campaign for the Protection of Rural Wales / Ymgyrch Diogelu Cymru Wledig CYF | Professional & scientific | 2022 |
| THE Canalside Company (Welshpool) Ltd | Wholesale & retail | 2013 |
| THE Celtic Care Company Ltd | Health & social care | 2021 |
| THE Cock of Forden Ltd | Hospitality | 2025 |
| THE Crewe Limited | Administrative & support | 2015 |
| THE Dragon Hotel Montgomery Ltd | Hospitality | 2013 |
| THE Garden Engineer Limited | Professional & scientific | 2022 |
| THE Great Outdoors Adventurers Club CIC | Health & social care | 2024 |
| THE Hair Studio Welshpool Limited | Other services | 2016 |
| THE Hill Rally Club | Arts & recreation | 2023 |
| THE Hive (Welshpool Creative-Arts Workshop) CIC | Arts & recreation | 2022 |
| THE Little Welsh Bakery Limited | Manufacturing | 2018 |
| THE Old Smithy Marton Limited | Administrative & support | 2015 |
| THE Royal Oak Hotel (Welshpool) Limited | Hospitality | 2006 |
| THE Tasty EGG Company Limited | Extraterritorial | 2017 |
| THE Trawscoed View Management Company Limited | Households | 2013 |