| Davam Utility Ltd | Construction | 2026 |
| Davelis Limited | Professional & scientific | 2022 |
| David Bernard Ltd | Mining & quarrying | 2007 |
| David Udale Holdings Limited | Financial services | 2021 |
| Davies & Goss Roofing Ltd | Construction | 2025 |
| Davies Commercial Refrigeration Ltd | Construction | 2024 |
| Day After Limited | Professional & scientific | 2022 |
| DBL Property Management Limited | Professional & scientific | 2012 |
| DEAKS579 Consulting Limited | Professional & scientific | 2014 |
| DED Comphee Limited | Manufacturing | 2024 |
| Deer Barn Ltd | Hospitality | 2018 |
| Delgado Properties Limited | Professional & scientific | 2003 |
| Delina Limited | Hospitality | 2026 |
| Delivend Ltd | Hospitality | 2020 |
| Delta Leisure Services Limited | Other services | 2019 |
| Deshi Spice Limited | Hospitality | 2024 |
| Design and Management Solutions Ltd | Administrative & support | 2006 |
| Developable Land Limited | Construction | 2025 |
| Developments South West Ltd | Construction | 2016 |
| Devon and Somerset Fire Protection Limited | Manufacturing | 2002 |
| Devon and Somerset Haulage Ltd | Transport & logistics | 2025 |
| Devon Hoof Care Ltd | Agriculture & fishing | 2018 |
| Devonspire Ltd | Transport & logistics | 2015 |
| DGH Systems Limited | Professional & scientific | 2011 |
| Didies Ltd | Other services | 2012 |
| Different Plane Ltd | Professional & scientific | 2020 |
| Dirty BBQ Ltd | Hospitality | 2017 |
| DJ Steve Events Ltd | Administrative & support | 2026 |
| Dklbb Ltd | Administrative & support | 2026 |
| DLS Social & Healthcare Ltd | Health & social care | 2019 |
| DM Contractors (Wellington) Limited | Administrative & support | 2000 |
| Domestic Sprinklers Devon and Somerset Limited | Public administration | 2013 |
| DON Kenn Ltd | Health & social care | 2022 |
| Dorset & Somerset Air Ambulance (Trading) Limited | Health & social care | 1999 |
| Dowell Close Management Company Limited | Real estate | 2013 |
| Drmgm Ltd | Information & communication | 2020 |
| Drone Survey Models Ltd | Professional & scientific | 2023 |
| Drop Everything and Read Limited | Wholesale & retail | 2024 |
| DSD Food Group Ltd | Wholesale & retail | 2001 |
| Dunford Farms Limited | Agriculture & fishing | 2025 |
| Dunn Bros SW Ltd | Wholesale & retail | 2022 |
| Dunster Biomass Heating Limited | Construction | 2012 |
| Dunster Energy Limited | Construction | 2016 |
| Dunster's Dairy Ltd | Manufacturing | 2025 |
| DVH Veterinary Sales Limited | Wholesale & retail | 2009 |
| E Wheels Mobile Repair Ltd | Other services | 2025 |
| E-Safe UK Limited | Extraterritorial | 2009 |
| Eastbrook Drive MAN. Co. Limited | Households | 2020 |
| Ecoprotex Limited | Construction | 2017 |
| Edpa Investments LLP | | 2024 |
| Edushop Limited | Professional & scientific | 2000 |
| Efficient Office Services Limited | Manufacturing | 2002 |
| Elegance Events Ltd | Hospitality | 2025 |
| Elele Consulting Limited | Information & communication | 2013 |
| Elele Solutions Limited | Extraterritorial | 2024 |
| Elite Cosmetic Repairs Limited | Wholesale & retail | 2002 |
| Elite Deliveries Ltd | Transport & logistics | 2025 |
| Elite Dressage International LLP | | 2018 |
| Elite Online Auctions Ltd | Wholesale & retail | 2025 |
| Elite S W Limited | Professional & scientific | 2016 |
| Elite Stallions (UK) Ltd | Agriculture & fishing | 2015 |
| Elite Stallions Trustees Ltd | Administrative & support | 2025 |
| Ellisons Commercial Training Limited | Education | 2021 |
| Ellisons School of Motoring Exeter Limited | Education | 2023 |
| Ellisons School of Motoring Ltd | Education | 2017 |
| Elouera Labs Ltd | Information & communication | 2026 |
| Ember Vault Ltd | Wholesale & retail | 2025 |
| Emea Projects Ltd | Professional & scientific | 2020 |
| Emericks Financial Services Limited | Financial services | 2013 |
| Enchantment at Langford Lakes Ltd | Arts & recreation | 2024 |
| EPD Consultants Ltd | Manufacturing | 2011 |
| Epitome Property Management Limited | Households | 2004 |
| Epoch Advisory Limited | Information & communication | 2024 |
| Equestrian Build UK Ltd | Construction | 2019 |
| Equiarts Ltd | Professional & scientific | 2024 |
| Equigene Ltd | Agriculture & fishing | 2025 |
| Ercall Investments Limited | Other services | 2022 |
| Erigeron Limited | Financial services | 2024 |
| Essential Beauty Supplies Limited | Wholesale & retail | 1997 |
| Essentials Express Ltd | Wholesale & retail | 2024 |
| EST 1954 Records Ltd | Arts & recreation | 2008 |
| EV Charging Assistant Ltd | Administrative & support | 2025 |
| Eveleigh Co Limited | Other services | 2016 |
| Evolution ABS (Trustees NO. 1) Limited | Extraterritorial | 2026 |
| Evolution ABS Limited | Professional & scientific | 2009 |
| Evolve Home Design & Build Ltd | Construction | 2019 |
| Evolve YOU Ltd | Administrative & support | 2016 |
| Exeter Motors Ltd | Wholesale & retail | 2016 |
| Exmoor Trees Limited | Agriculture & fishing | 2021 |
| Exmoor Woodfuel Ltd | Agriculture & fishing | 2014 |
| Experist Limited | Professional & scientific | 2017 |
| F & M Coate Ltd | Agriculture & fishing | 2019 |
| F and R Products Limited | Manufacturing | 2012 |
| F.I.T SW Ltd | Education | 2026 |
| Farming and Wildlife Administration Limited | Other services | 2013 |
| Farming and Wildlife Advisory Group South West Ltd | Professional & scientific | 2011 |
| Farmstrong Ltd | Professional & scientific | 2024 |
| Febwell & Co Limited | Real estate | 1971 |
| Fieldsports Channel Ltd | Information & communication | 2018 |
| Fieldsports Television Ltd | Information & communication | 2010 |